FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165087809> ?p ?o ?g. }

• W2165087809 endingPage "3061" @default.
• W2165087809 startingPage "3054" @default.
• W2165087809 abstract "Considerable evidence supports the hypothesis that estrogen prevents bone loss by blocking the production of cytokines in bone or bone marrow. However, controversy remains on the role of candidate factors, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF). As IL-1 and TNF have many additive and/or synergistic effects in bone, we tested the hypothesis that the simultaneous block of IL-1 and TNF is required to prevent the initial phase of rapid bone loss that follows ovariectomy (ovx). To this aim, rats were ovariectomized and treated for 2 weeks with either IL-1 receptor antagonist (IL-1ra), an inhibitor of IL-1, or TNF-binding protein (TNFbp), an inhibitor of TNF. Ovx increased bone marrow cell secretion of IL-1 and TNF and decreased the bone density of the distal femur, as measured by dual energy x-ray absorptiometry. Ovx-induced bone loss was decreased by both IL-1ra and TNFbp and completely prevented by simultaneous treatment with IL-1ra and TNFbp. Combined treatment with IL-1ra and TNFbp decreased urinary pyridinoline cross-links, a marker of bone resorption that reflects osteoclast number and osteoclast activity, whereas treatment with either inhibitor alone was less effective. Both IL-1ra and TNFbp decreased the number of osteoclasts on the endocortical surfaces and stimulated bone formation, but the two inhibitors had no additive effects on these indexes, suggesting that inhibition of osteoclastogenesis and stimulation of bone formation do not account for the additive bone-sparing effects of IL-1ra and TNFbp. These inhibitors had no effect in sham-operated rats, indicating that they specifically blocked estrogen-dependent events. In conclusion, these data indicate that in the early post-ovx period, IL-1 and TNF play a critical causal role in inducing bone loss and do so by stimulating bone resorption and inhibiting bone formation." @default.
• W2165087809 created "2016-06-24" @default.
• W2165087809 creator A5014681820 @default.
• W2165087809 creator A5014986694 @default.
• W2165087809 creator A5025423903 @default.
• W2165087809 creator A5060971800 @default.
• W2165087809 creator A5063445805 @default.
• W2165087809 creator A5074334343 @default.
• W2165087809 date "1995-07-01" @default.
• W2165087809 modified "2023-10-10" @default.
• W2165087809 title "Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period." @default.
• W2165087809 cites W1527149701 @default.
• W2165087809 cites W1585377912 @default.
• W2165087809 cites W1588586232 @default.
• W2165087809 cites W1965568869 @default.
• W2165087809 cites W1970595375 @default.
• W2165087809 cites W1975587041 @default.
• W2165087809 cites W1976445312 @default.
• W2165087809 cites W1980786945 @default.
• W2165087809 cites W1996028579 @default.
• W2165087809 cites W2008159943 @default.
• W2165087809 cites W2008679227 @default.
• W2165087809 cites W2019308648 @default.
• W2165087809 cites W2031504111 @default.
• W2165087809 cites W2038285488 @default.
• W2165087809 cites W2073598149 @default.
• W2165087809 cites W2074704125 @default.
• W2165087809 cites W2076558444 @default.
• W2165087809 cites W2094834328 @default.
• W2165087809 cites W2096142466 @default.
• W2165087809 cites W2100484245 @default.
• W2165087809 cites W2106432805 @default.
• W2165087809 cites W2119995064 @default.
• W2165087809 cites W2125168145 @default.
• W2165087809 cites W2133408673 @default.
• W2165087809 cites W2141591906 @default.
• W2165087809 cites W2160051896 @default.
• W2165087809 cites W2161697663 @default.
• W2165087809 cites W2164019859 @default.
• W2165087809 cites W2164322090 @default.
• W2165087809 cites W2399461476 @default.
• W2165087809 cites W263209289 @default.
• W2165087809 doi "https://doi.org/10.1210/endo.136.7.7789332" @default.
• W2165087809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7789332" @default.
• W2165087809 hasPublicationYear "1995" @default.
• W2165087809 type Work @default.
• W2165087809 sameAs 2165087809 @default.
• W2165087809 citedByCount "209" @default.
• W2165087809 countsByYear W21650878092012 @default.
• W2165087809 countsByYear W21650878092013 @default.
• W2165087809 countsByYear W21650878092014 @default.
• W2165087809 countsByYear W21650878092015 @default.
• W2165087809 countsByYear W21650878092016 @default.
• W2165087809 countsByYear W21650878092017 @default.
• W2165087809 countsByYear W21650878092018 @default.
• W2165087809 countsByYear W21650878092019 @default.
• W2165087809 countsByYear W21650878092020 @default.
• W2165087809 countsByYear W21650878092021 @default.
• W2165087809 countsByYear W21650878092022 @default.
• W2165087809 countsByYear W21650878092023 @default.
• W2165087809 crossrefType "journal-article" @default.
• W2165087809 hasAuthorship W2165087809A5014681820 @default.
• W2165087809 hasAuthorship W2165087809A5014986694 @default.
• W2165087809 hasAuthorship W2165087809A5025423903 @default.
• W2165087809 hasAuthorship W2165087809A5060971800 @default.
• W2165087809 hasAuthorship W2165087809A5063445805 @default.
• W2165087809 hasAuthorship W2165087809A5074334343 @default.
• W2165087809 hasConcept C126322002 @default.
• W2165087809 hasConcept C134018914 @default.
• W2165087809 hasConcept C170033053 @default.
• W2165087809 hasConcept C170493617 @default.
• W2165087809 hasConcept C17991360 @default.
• W2165087809 hasConcept C185592680 @default.
• W2165087809 hasConcept C2776033226 @default.
• W2165087809 hasConcept C2777164284 @default.
• W2165087809 hasConcept C2778690821 @default.
• W2165087809 hasConcept C2780007613 @default.
• W2165087809 hasConcept C673006 @default.
• W2165087809 hasConcept C71924100 @default.
• W2165087809 hasConcept C74172505 @default.
• W2165087809 hasConcept C8264082 @default.
• W2165087809 hasConceptScore W2165087809C126322002 @default.
• W2165087809 hasConceptScore W2165087809C134018914 @default.
• W2165087809 hasConceptScore W2165087809C170033053 @default.
• W2165087809 hasConceptScore W2165087809C170493617 @default.
• W2165087809 hasConceptScore W2165087809C17991360 @default.
• W2165087809 hasConceptScore W2165087809C185592680 @default.
• W2165087809 hasConceptScore W2165087809C2776033226 @default.
• W2165087809 hasConceptScore W2165087809C2777164284 @default.
• W2165087809 hasConceptScore W2165087809C2778690821 @default.
• W2165087809 hasConceptScore W2165087809C2780007613 @default.
• W2165087809 hasConceptScore W2165087809C673006 @default.
• W2165087809 hasConceptScore W2165087809C71924100 @default.
• W2165087809 hasConceptScore W2165087809C74172505 @default.
• W2165087809 hasConceptScore W2165087809C8264082 @default.
• W2165087809 hasIssue "7" @default.
• W2165087809 hasLocation W21650878091 @default.
• W2165087809 hasLocation W21650878092 @default.

• next