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- W216511784 abstract "Objective To study genital toxicity and didymus lipid peroxidation level on rats after sub-acute exposure to di-2-ethylhexyl phthalate(DEHP).Methods The weaning Wistar andro-rats were dividied into four group randomly,and there were 10 rats in each group.Compared with the corn oil control,the experiment groups were gavaged consecutively for 30 days with the DEHP dose of 10,100,1 000 mg/(kg.d),The change of body weight was observed dynamically.All rats were executed by decapitation four weeks later and the didymium was removed immediately,at the same time viscera coefficient were measured.The level of MDA were detected by TBA method,meanwhile GSH level and GSH-Px activity were analyzed by modified DTNB method,the activity of SOD were measured by xanthine oxidase method.Results With the increasement of DEHP concentration,the body weight growth of rats in 1 000 mg/(kg.d) DEHP group is restricted compared with the control(P0.05).Both the weight of didymium and the organ coefficient were decreased.There were statistical significance between the 1 000 mg/(kg.d) DEHP group and the control(P0.05).In addition,the level of GSH in high dose group decreased,the GSH-Px and SOD activity decreased too,compared with the control group(P0.05).The content of MDA increased following the increasing dose of DEHP.The significant difference between each group existed(P0.05).Conclusion Genital toxicity in weaning andro-rats were observed after sub-acute exposure to DEHP.The spermary weight decreased,which showed incomplete growth.The level of lipid peroxidation in dydimus exposed to 1 000 mg/(kg.d) DEHP increased obviously,meanwhile oxidative damage from DEHP or MEHP maybe become one of the important mechanisms of genesis toxicity on male rats during the developmental phase." @default.
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- W216511784 date "2009-01-01" @default.
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- W216511784 title "Study on didymus lipid peroxidation level on rats after sub-acute exposure to Di-2-ethylhexyl phthalate." @default.
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