FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165139790> ?p ?o ?g. }

• W2165139790 endingPage "51" @default.
• W2165139790 startingPage "42" @default.
• W2165139790 abstract "We develop a proof-of-principle model for auto-regulation of water volume in the lung airway surface layer (ASL) by coupling biochemical kinetics, transient ASL volume, and homeostatic mechanical stresses. The model is based on the hypothesis that ASL volume is sensed through soluble mediators and phasic stresses generated by beating cilia and air drag forces. Model parameters are fit based on the available data on human bronchial epithelial cell cultures. Simulations then demonstrate that homeostatic volume regulation is a natural consequence of the processes described. The model maintains ASL volume within a physiological range that modulates with phasic stress frequency and amplitude. Next, we show that the model successfully reproduces the responses of cell cultures to significant isotonic and hypotonic challenges, and to hypertonic saline, an effective therapy for mucus hydration in cystic fibrosis patients. These results compel an advanced airway hydration model with therapeutic value that will necessitate detailed kinetics of multiple molecular pathways, feedback to ASL viscoelasticity properties, and stress signaling from the ASL to the cilia and epithelial cells." @default.
• W2165139790 created "2016-06-24" @default.
• W2165139790 creator A5002387944 @default.
• W2165139790 creator A5030886600 @default.
• W2165139790 creator A5039335591 @default.
• W2165139790 creator A5051776064 @default.
• W2165139790 creator A5066447096 @default.
• W2165139790 creator A5068876393 @default.
• W2165139790 creator A5081308541 @default.
• W2165139790 creator A5085878974 @default.
• W2165139790 date "2013-05-01" @default.
• W2165139790 modified "2023-10-16" @default.
• W2165139790 title "A mechanochemical model for auto-regulation of lung airway surface layer volume" @default.
• W2165139790 cites W141337735 @default.
• W2165139790 cites W1505008375 @default.
• W2165139790 cites W1526250671 @default.
• W2165139790 cites W1576988249 @default.
• W2165139790 cites W187185975 @default.
• W2165139790 cites W1978028270 @default.
• W2165139790 cites W1987751707 @default.
• W2165139790 cites W1990462225 @default.
• W2165139790 cites W1995571816 @default.
• W2165139790 cites W2010844072 @default.
• W2165139790 cites W2020942539 @default.
• W2165139790 cites W2022634662 @default.
• W2165139790 cites W2024485063 @default.
• W2165139790 cites W2037487835 @default.
• W2165139790 cites W2042439280 @default.
• W2165139790 cites W2043728729 @default.
• W2165139790 cites W2050548922 @default.
• W2165139790 cites W2070649129 @default.
• W2165139790 cites W2078321992 @default.
• W2165139790 cites W2085734245 @default.
• W2165139790 cites W2101594367 @default.
• W2165139790 cites W2103865390 @default.
• W2165139790 cites W2107893709 @default.
• W2165139790 cites W2108676410 @default.
• W2165139790 cites W2114839257 @default.
• W2165139790 cites W2118823673 @default.
• W2165139790 cites W2120112732 @default.
• W2165139790 cites W2121563770 @default.
• W2165139790 cites W2145979332 @default.
• W2165139790 cites W2160484729 @default.
• W2165139790 cites W2165420508 @default.
• W2165139790 cites W2259743896 @default.
• W2165139790 cites W2401010764 @default.
• W2165139790 cites W91752135 @default.
• W2165139790 doi "https://doi.org/10.1016/j.jtbi.2013.01.023" @default.
• W2165139790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3631568" @default.
• W2165139790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23415939" @default.
• W2165139790 hasPublicationYear "2013" @default.
• W2165139790 type Work @default.
• W2165139790 sameAs 2165139790 @default.
• W2165139790 citedByCount "15" @default.
• W2165139790 countsByYear W21651397902013 @default.
• W2165139790 countsByYear W21651397902014 @default.
• W2165139790 countsByYear W21651397902015 @default.
• W2165139790 countsByYear W21651397902017 @default.
• W2165139790 countsByYear W21651397902018 @default.
• W2165139790 countsByYear W21651397902019 @default.
• W2165139790 countsByYear W21651397902020 @default.
• W2165139790 countsByYear W21651397902023 @default.
• W2165139790 crossrefType "journal-article" @default.
• W2165139790 hasAuthorship W2165139790A5002387944 @default.
• W2165139790 hasAuthorship W2165139790A5030886600 @default.
• W2165139790 hasAuthorship W2165139790A5039335591 @default.
• W2165139790 hasAuthorship W2165139790A5051776064 @default.
• W2165139790 hasAuthorship W2165139790A5066447096 @default.
• W2165139790 hasAuthorship W2165139790A5068876393 @default.
• W2165139790 hasAuthorship W2165139790A5081308541 @default.
• W2165139790 hasAuthorship W2165139790A5085878974 @default.
• W2165139790 hasBestOaLocation W21651397902 @default.
• W2165139790 hasConcept C100094513 @default.
• W2165139790 hasConcept C117277713 @default.
• W2165139790 hasConcept C12554922 @default.
• W2165139790 hasConcept C134018914 @default.
• W2165139790 hasConcept C169760540 @default.
• W2165139790 hasConcept C185592680 @default.
• W2165139790 hasConcept C3017567848 @default.
• W2165139790 hasConcept C55493867 @default.
• W2165139790 hasConcept C63645605 @default.
• W2165139790 hasConcept C86803240 @default.
• W2165139790 hasConcept C95444343 @default.
• W2165139790 hasConceptScore W2165139790C100094513 @default.
• W2165139790 hasConceptScore W2165139790C117277713 @default.
• W2165139790 hasConceptScore W2165139790C12554922 @default.
• W2165139790 hasConceptScore W2165139790C134018914 @default.
• W2165139790 hasConceptScore W2165139790C169760540 @default.
• W2165139790 hasConceptScore W2165139790C185592680 @default.
• W2165139790 hasConceptScore W2165139790C3017567848 @default.
• W2165139790 hasConceptScore W2165139790C55493867 @default.
• W2165139790 hasConceptScore W2165139790C63645605 @default.
• W2165139790 hasConceptScore W2165139790C86803240 @default.
• W2165139790 hasConceptScore W2165139790C95444343 @default.
• W2165139790 hasLocation W21651397901 @default.
• W2165139790 hasLocation W21651397902 @default.
• W2165139790 hasLocation W21651397903 @default.
• W2165139790 hasLocation W21651397904 @default.

• next