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- W2165140711 abstract "(Headache 2012;52:765-772) Objectives/Background.— (1) To investigate whether a parsimonious model for sumatriptan pharmacokinetics can apply to oral administration; (2) for a successful model, whether a monoamine oxidase A inhibitor (MAOI-A) perturbs it; and (3) whether such a model is generalizable to oral almotriptan. These goals respond to statements in US product labeling. Methods.— Extension of a previous model for subcutaneous sumatriptan. Numerical solutions to 3 concurrent differential equations were found, with prospective criteria for model acceptance based upon comparison with clinically observed data. Results.— The model was successfully extended by inserting a time factor into the absorption phase. This extension was robust: it imitated clinical data for 3 oral sumatriptan dose sizes (both without and with a concomitant MAOI-A) and also for oral almotriptan. Conclusion.— A model for oral sumatriptan pharmacokinetics can be found using the differential calculus, and it is generalizable to oral almotriptan. The model suggests that an MAOI-A probably has greater effect on elimination kinetics than first-pass metabolism, and that this interaction appears to be overstated in product labeling." @default.
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- W2165140711 date "2012-03-21" @default.
- W2165140711 modified "2023-09-28" @default.
- W2165140711 title "Oral Sumatriptan and Almotriptan - Delimiting the MAOI Effect" @default.
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- W2165140711 doi "https://doi.org/10.1111/j.1526-4610.2012.02113.x" @default.
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