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- W2165159940 abstract "The presence of isopilocarpine, an epimer of pilocarpine, and of pilocarpinic acid, a hydrolytic degradation product of pilocarpine, was established and all three substances were assayed in various commercial ophthalmic formulations of pilocarpine hydrochloride by 13C-Fourier transform spectroscopy. Assay was based upon integrated intensities of selected resonances from any formulation calibrated against the intensity of tetramethylammonium bromide, used as a common external reference. The normalized intensities were then related to those of a reference solution of pilocarpine hydrochloride, thereby eliminating any factor arising from variability of 13C-relaxation times. The 13C-resonance for the N-methyl group, being common to all products, provides a convenient basis for the assay of the total alkaloid content whereas the C-8 resonances are best suited for assaying residual pilocarpine and its degradation products. This procedure, estimated as accurate to +/- 5%, constitutes the first comprehensive analytical method to differentiate between pilocarpine and its degradation products." @default.
- W2165159940 created "2016-06-24" @default.
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- W2165159940 date "1977-05-01" @default.
- W2165159940 modified "2023-09-27" @default.
- W2165159940 title "Quantitative Analysis of Degradation Products in Pilocarpine Hydrochloride Ophthalmic Formulations" @default.
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- W2165159940 doi "https://doi.org/10.1002/jps.2600660508" @default.
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