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• W2165219563 abstract "We identified the promoter region of the human GD3 synthase (hST8Sia I) gene to elucidate the mechanism underlying the regulation of hST8Sia I expression in human glioblastoma cells. The 5'-rapid amplification of cDNA end using mRNA prepared from U-87MG cells revealed the presence of transcription start site of hST8Sia I gene, and the 5'-terminal analysis of its product showed that transcription started from 648 nucleotides upstream of the translational initiation site. Functional analysis of the 5'-flanking region of the hST8Sia I gene by transient expression method revealed that the region from -638 to -498 is important for transcriptional activity of the hST8Sia I gene in U-87MG and T98G cells. This region lacks apparent TATA and CAAT boxes, but contains putative binding sites for transcription factors AREB6 and Elk-1. Site-directed mutagenesis and transient transfection assays demonstrated that both AREB6 and Elk-1 elements in this region were required for the promoter activity in U-87MG and T98G cells. These results indicated that both AREB6 and Elk-1 might play an essential role in the transcriptional activity of hST8Sia I gene essential for GD3 synthesis in human glioblastoma cells." @default.
• W2165219563 created "2016-06-24" @default.
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• W2165219563 date "2009-03-01" @default.
• W2165219563 modified "2023-09-23" @default.
• W2165219563 title "Isolation and functional analysis of the human glioblastoma-specific promoter region of the human GD3 synthase (&lt;italic&gt;hST8Sia I&lt;/italic&gt;) gene" @default.
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• W2165219563 doi "https://doi.org/10.1093/abbs/gmp007" @default.
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