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- W2165220571 endingPage "777" @default.
- W2165220571 startingPage "761" @default.
- W2165220571 abstract "The first clinical evaluations of adenovirus (Ad)-based vectors for gene therapy were initiated in the mid-1990s and led to great anticipation for future utility. However, excitement surrounding gene therapy, particularly Ad-based therapy, was diminished upon the death of Jesse Gelsinger, and recent discouraging results from the HIV vaccine STEP trial have brought efficacy and safety issues to the forefront again. Even so, Ad vectors are still considered among the safest and most effective vaccine vectors. Innate and pre-existing immunity to Ad mediate much of the acute toxicities and reduced therapeutic efficacies observed following vaccination with this vector. Thus, innovative strategies must continue to be developed to reduce Ad-specific antigenicity and immune recognition. This review provides an overview and critique of the most promising strategies, including results from preclinical trials in mice and nonhuman primates, which aim to revive the future of Ad-based vaccines." @default.
- W2165220571 created "2016-06-24" @default.
- W2165220571 creator A5024261192 @default.
- W2165220571 creator A5054730477 @default.
- W2165220571 creator A5090846377 @default.
- W2165220571 date "2009-06-01" @default.
- W2165220571 modified "2023-10-16" @default.
- W2165220571 title "Strategies to overcome host immunity to adenovirus vectors in vaccine development" @default.
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