FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165223513> ?p ?o ?g. }

• W2165223513 endingPage "2091" @default.
• W2165223513 startingPage "2083" @default.
• W2165223513 abstract "Tolerance refers to the phenomenon that bacteria do not significantly die when exposed to bactericidal antibiotics. Enterococci are known for their high tolerance to these drugs, but the molecular reasons why they resist killing are not understood. In a previous study we showed that the superoxide dismutase (SOD) is implicated in this tolerance. This conclusion was based on the results obtained with one particular strain of Enterococcus faecalis and therefore the objective of the present communication was to analyse whether dependence of tolerance on active SOD is a general phenomenon for enterococci and another Gram-positive pathogen, Staphylococcus aureus. Mutants deficient in SOD activity were constructed in pathogenic enterococci. The wild-type sodA gene was cloned into an expression vector and transformed into SOD-deficient strains for complementation with varying levels of SOD activity. Previously constructed SOD-deficient strains of S. aureus were also included in this study. Tolerance to vancomycin and penicillin was then tested. We demonstrated that the dependence on SOD of tolerance to vancomycin and penicillin is a common trait of antibiotic-susceptible pathogenic enterococci. By varying the levels of expression we could also show that tolerance to vancomycin is directly correlated to SOD activity. Interestingly, deletion of the sodA gene in a non-tolerant Enterococcus faecium strain did not further sensitize the mutant to bactericidal antibiotics. Finally, we showed that the SOD enzymes of S. aureus are also implicated in tolerance to vancomycin. High tolerance of enterococci to cell wall active antibiotics can be reversed by SOD deficiency." @default.
• W2165223513 created "2016-06-24" @default.
• W2165223513 creator A5002377470 @default.
• W2165223513 creator A5009754940 @default.
• W2165223513 creator A5033663389 @default.
• W2165223513 creator A5047541127 @default.
• W2165223513 creator A5064468023 @default.
• W2165223513 creator A5085786872 @default.
• W2165223513 creator A5090574049 @default.
• W2165223513 date "2013-05-06" @default.
• W2165223513 modified "2023-09-27" @default.
• W2165223513 title "Analysis of the tolerance of pathogenic enterococci and Staphylococcus aureus to cell wall active antibiotics" @default.
• W2165223513 cites W1482153955 @default.
• W2165223513 cites W1519064016 @default.
• W2165223513 cites W1548162677 @default.
• W2165223513 cites W1604193428 @default.
• W2165223513 cites W1830055331 @default.
• W2165223513 cites W1969241748 @default.
• W2165223513 cites W1972249440 @default.
• W2165223513 cites W1973437578 @default.
• W2165223513 cites W1977465870 @default.
• W2165223513 cites W1978163337 @default.
• W2165223513 cites W1982029231 @default.
• W2165223513 cites W1985725647 @default.
• W2165223513 cites W2001079530 @default.
• W2165223513 cites W2035145746 @default.
• W2165223513 cites W2038779898 @default.
• W2165223513 cites W2040720195 @default.
• W2165223513 cites W2054114849 @default.
• W2165223513 cites W2061193364 @default.
• W2165223513 cites W2072023518 @default.
• W2165223513 cites W2081851349 @default.
• W2165223513 cites W2087431924 @default.
• W2165223513 cites W2095659555 @default.
• W2165223513 cites W2100837269 @default.
• W2165223513 cites W2101422765 @default.
• W2165223513 cites W2106277867 @default.
• W2165223513 cites W2108954741 @default.
• W2165223513 cites W2117087393 @default.
• W2165223513 cites W2117840606 @default.
• W2165223513 cites W2118378514 @default.
• W2165223513 cites W2121324944 @default.
• W2165223513 cites W2131315375 @default.
• W2165223513 cites W2132050847 @default.
• W2165223513 cites W2137677278 @default.
• W2165223513 cites W2146155543 @default.
• W2165223513 cites W2146481325 @default.
• W2165223513 cites W2146584445 @default.
• W2165223513 cites W2157220975 @default.
• W2165223513 cites W2167311781 @default.
• W2165223513 cites W2169279122 @default.
• W2165223513 cites W2171598572 @default.
• W2165223513 cites W4246117097 @default.
• W2165223513 cites W4293247451 @default.
• W2165223513 cites W794073544 @default.
• W2165223513 doi "https://doi.org/10.1093/jac/dkt157" @default.
• W2165223513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23649229" @default.
• W2165223513 hasPublicationYear "2013" @default.
• W2165223513 type Work @default.
• W2165223513 sameAs 2165223513 @default.
• W2165223513 citedByCount "34" @default.
• W2165223513 countsByYear W21652235132014 @default.
• W2165223513 countsByYear W21652235132015 @default.
• W2165223513 countsByYear W21652235132016 @default.
• W2165223513 countsByYear W21652235132018 @default.
• W2165223513 countsByYear W21652235132019 @default.
• W2165223513 countsByYear W21652235132020 @default.
• W2165223513 countsByYear W21652235132021 @default.
• W2165223513 countsByYear W21652235132022 @default.
• W2165223513 crossrefType "journal-article" @default.
• W2165223513 hasAuthorship W2165223513A5002377470 @default.
• W2165223513 hasAuthorship W2165223513A5009754940 @default.
• W2165223513 hasAuthorship W2165223513A5033663389 @default.
• W2165223513 hasAuthorship W2165223513A5047541127 @default.
• W2165223513 hasAuthorship W2165223513A5064468023 @default.
• W2165223513 hasAuthorship W2165223513A5085786872 @default.
• W2165223513 hasAuthorship W2165223513A5090574049 @default.
• W2165223513 hasBestOaLocation W21652235131 @default.
• W2165223513 hasConcept C104317684 @default.
• W2165223513 hasConcept C136622501 @default.
• W2165223513 hasConcept C143065580 @default.
• W2165223513 hasConcept C174802600 @default.
• W2165223513 hasConcept C181199279 @default.
• W2165223513 hasConcept C2775838275 @default.
• W2165223513 hasConcept C2777677444 @default.
• W2165223513 hasConcept C2778980435 @default.
• W2165223513 hasConcept C2779489039 @default.
• W2165223513 hasConcept C2779895986 @default.
• W2165223513 hasConcept C2780585763 @default.
• W2165223513 hasConcept C501593827 @default.
• W2165223513 hasConcept C523546767 @default.
• W2165223513 hasConcept C54355233 @default.
• W2165223513 hasConcept C55493867 @default.
• W2165223513 hasConcept C58123911 @default.
• W2165223513 hasConcept C86803240 @default.
• W2165223513 hasConcept C89423630 @default.
• W2165223513 hasConceptScore W2165223513C104317684 @default.
• W2165223513 hasConceptScore W2165223513C136622501 @default.

• next