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• W2165256793 abstract "A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-alpha production. X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction." @default.
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• W2165256793 date "2006-07-01" @default.
• W2165256793 modified "2023-10-17" @default.
• W2165256793 title "Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1" @default.
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• W2165256793 doi "https://doi.org/10.1016/j.bmcl.2006.03.095" @default.
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