FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165271507> ?p ?o ?g. }

• W2165271507 abstract "Hypermethylation of gene promoters and the corresponding loss of gene expression are recognized as a hallmark of human cancer, and DNA methylation has emerged as a promising biomarker for the detection of human esophageal squamous cell carcinoma (ESCC). To identify novel genes methylated in ESCC, we screened 35 candidate genes identified from an oligonucleotide microarray. Among them, the heat shock protein B2 (HSPB2) was methylated in 95.7% (67/70) of primary ESCCs, whereas no methylation was found in normal esophageal tissues from ESCC patients (0%, 0/20). RT-PCR analysis revealed that HSPB2 expression was silenced or weakly expressed in most ESCC cell lines, and re-activated by the demethylating agent 5-aza-2'-deoxy-cytidine. These results indicate that promoter methylation of HSPB2 is one of the causal factors for loss or down-regulation of HSPB2 expression. mRNA expression of HSPB2 in ESCC tissues was significantly down-regulated compared to normal tissues. Our data suggest that promoter methylation of HSPB2 deserves further attention as a novel molecular biomarker in human ESCC." @default.
• W2165271507 created "2016-06-24" @default.
• W2165271507 creator A5006427788 @default.
• W2165271507 creator A5018208537 @default.
• W2165271507 creator A5049209796 @default.
• W2165271507 creator A5075243118 @default.
• W2165271507 date "2011-04-01" @default.
• W2165271507 modified "2023-09-28" @default.
• W2165271507 title "Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma" @default.
• W2165271507 cites W132907432 @default.
• W2165271507 cites W1528597874 @default.
• W2165271507 cites W1552528612 @default.
• W2165271507 cites W1646723094 @default.
• W2165271507 cites W1967108607 @default.
• W2165271507 cites W1968658624 @default.
• W2165271507 cites W1971653050 @default.
• W2165271507 cites W1975509789 @default.
• W2165271507 cites W1976462601 @default.
• W2165271507 cites W1985676388 @default.
• W2165271507 cites W1987483412 @default.
• W2165271507 cites W1987585617 @default.
• W2165271507 cites W1988672799 @default.
• W2165271507 cites W1994117816 @default.
• W2165271507 cites W1996495124 @default.
• W2165271507 cites W2006038989 @default.
• W2165271507 cites W2010444010 @default.
• W2165271507 cites W2026043086 @default.
• W2165271507 cites W2029476406 @default.
• W2165271507 cites W2030368821 @default.
• W2165271507 cites W2044818530 @default.
• W2165271507 cites W2046603670 @default.
• W2165271507 cites W2050203542 @default.
• W2165271507 cites W2052380717 @default.
• W2165271507 cites W2053416934 @default.
• W2165271507 cites W2057594007 @default.
• W2165271507 cites W2061238003 @default.
• W2165271507 cites W2063956958 @default.
• W2165271507 cites W2082805232 @default.
• W2165271507 cites W2103163028 @default.
• W2165271507 cites W2112846356 @default.
• W2165271507 cites W2114649999 @default.
• W2165271507 cites W2133181350 @default.
• W2165271507 cites W2142102889 @default.
• W2165271507 cites W2144488343 @default.
• W2165271507 cites W2155528300 @default.
• W2165271507 cites W2158685104 @default.
• W2165271507 cites W2159359514 @default.
• W2165271507 cites W2160777869 @default.
• W2165271507 cites W2188459559 @default.
• W2165271507 cites W2194064760 @default.
• W2165271507 cites W2314885155 @default.
• W2165271507 cites W2343423788 @default.
• W2165271507 cites W2407082255 @default.
• W2165271507 cites W2916917221 @default.
• W2165271507 cites W44419044 @default.
• W2165271507 cites W191375927 @default.
• W2165271507 doi "https://doi.org/10.3892/ijo.2011.918" @default.
• W2165271507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3309605" @default.
• W2165271507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21258768" @default.
• W2165271507 hasPublicationYear "2011" @default.
• W2165271507 type Work @default.
• W2165271507 sameAs 2165271507 @default.
• W2165271507 citedByCount "6" @default.
• W2165271507 countsByYear W21652715072013 @default.
• W2165271507 countsByYear W21652715072014 @default.
• W2165271507 countsByYear W21652715072019 @default.
• W2165271507 countsByYear W21652715072022 @default.
• W2165271507 crossrefType "journal-article" @default.
• W2165271507 hasAuthorship W2165271507A5006427788 @default.
• W2165271507 hasAuthorship W2165271507A5018208537 @default.
• W2165271507 hasAuthorship W2165271507A5049209796 @default.
• W2165271507 hasAuthorship W2165271507A5075243118 @default.
• W2165271507 hasBestOaLocation W21652715071 @default.
• W2165271507 hasConcept C101762097 @default.
• W2165271507 hasConcept C104317684 @default.
• W2165271507 hasConcept C121608353 @default.
• W2165271507 hasConcept C140173407 @default.
• W2165271507 hasConcept C150194340 @default.
• W2165271507 hasConcept C153911025 @default.
• W2165271507 hasConcept C189235521 @default.
• W2165271507 hasConcept C190727270 @default.
• W2165271507 hasConcept C205260736 @default.
• W2165271507 hasConcept C2779277951 @default.
• W2165271507 hasConcept C2781018059 @default.
• W2165271507 hasConcept C2781197716 @default.
• W2165271507 hasConcept C29537977 @default.
• W2165271507 hasConcept C33288867 @default.
• W2165271507 hasConcept C502942594 @default.
• W2165271507 hasConcept C54355233 @default.
• W2165271507 hasConcept C86803240 @default.
• W2165271507 hasConceptScore W2165271507C101762097 @default.
• W2165271507 hasConceptScore W2165271507C104317684 @default.
• W2165271507 hasConceptScore W2165271507C121608353 @default.
• W2165271507 hasConceptScore W2165271507C140173407 @default.
• W2165271507 hasConceptScore W2165271507C150194340 @default.
• W2165271507 hasConceptScore W2165271507C153911025 @default.
• W2165271507 hasConceptScore W2165271507C189235521 @default.
• W2165271507 hasConceptScore W2165271507C190727270 @default.
• W2165271507 hasConceptScore W2165271507C205260736 @default.
• W2165271507 hasConceptScore W2165271507C2779277951 @default.

• next