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• W2165287910 abstract "Abstract Two models (octanol:buffer and lipid:buffer) were used to estimate the interaction of ciprofloxacin and two alkyl derivatives with neutral membranes. To investigate the existence of a mechanism of permeation through the lipid bilayers quenching methods of fluorescence were applied to ciprofloxacin liposomes in order to discriminate relative membrane location of ciprofloxacin. Different mechanisms of quenching appear depending on conditions (pH 4.80, 7.40 and 9.10) which were interpreted under the basis of 6-fluoroquinolone microspeciation and the ability of only the neutral microspecies to permeate across apolar environments. No major effects of temperature (below and above transition temperature, T m ) on quenching mechanism were observed. The high accessibility for iodide shown by ciprofloxacin and its methyl and ethyl derivatives together with the low drug/phospholipid ratio indicate a fast release of the drug from liposomes. Previously the quenching effect of iodide on ciprofloxacin and its inability to access the apolar hydrophobic regions of the bilayers were studied." @default.
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• W2165287910 date "1998-08-01" @default.
• W2165287910 modified "2023-10-13" @default.
• W2165287910 title "6-Fluoroquinolone–liposome interactions: fluorescence quenching study using iodide" @default.
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• W2165287910 doi "https://doi.org/10.1016/s0378-5173(98)00154-9" @default.
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