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- W2165290124 endingPage "4088" @default.
- W2165290124 startingPage "4073" @default.
- W2165290124 abstract "The voltage-gated potassium channel Kv1.2 undergoes tyrosine phosphorylation-dependent suppression of its ionic current. However, little is known about the physical mechanism behind that process. We have found that the Kv1.2 alpha-subunit protein undergoes endocytosis in response to the same stimuli that evoke suppression of Kv1.2 ionic current. The process is tyrosine phosphorylation-dependent because the same tyrosine to phenylalanine mutation in the N-terminus of Kv1.2 that confers resistance to channel suppression (Y132F) also confers resistance to channel endocytosis. Overexpression of a dominant negative form of dynamin blocked stimulus-induced Kv1.2 endocytosis and also blocked suppression of Kv1.2 ionic current. These data indicate that endocytosis of Kv1.2 from the cell surface is a key mechanism for channel suppression by tyrosine kinases." @default.
- W2165290124 created "2016-06-24" @default.
- W2165290124 creator A5011780265 @default.
- W2165290124 creator A5039299837 @default.
- W2165290124 creator A5062626999 @default.
- W2165290124 date "2004-09-01" @default.
- W2165290124 modified "2023-10-05" @default.
- W2165290124 title "Endocytosis as a Mechanism for Tyrosine Kinase-dependent Suppression of a Voltage-gated Potassium Channel" @default.
- W2165290124 cites W1492144011 @default.
- W2165290124 cites W1510586838 @default.
- W2165290124 cites W1552201117 @default.
- W2165290124 cites W1770697547 @default.
- W2165290124 cites W1964285407 @default.
- W2165290124 cites W1965689213 @default.
- W2165290124 cites W1965770990 @default.
- W2165290124 cites W1975126814 @default.
- W2165290124 cites W1979870127 @default.
- W2165290124 cites W1980902873 @default.
- W2165290124 cites W1982643313 @default.
- W2165290124 cites W1984653721 @default.
- W2165290124 cites W1991334194 @default.
- W2165290124 cites W1999788892 @default.
- W2165290124 cites W2002494433 @default.
- W2165290124 cites W2003729768 @default.
- W2165290124 cites W2007563402 @default.
- W2165290124 cites W2009009539 @default.
- W2165290124 cites W2009582035 @default.
- W2165290124 cites W2011605309 @default.
- W2165290124 cites W2012652910 @default.
- W2165290124 cites W2012799858 @default.
- W2165290124 cites W2015752928 @default.
- W2165290124 cites W2016425872 @default.
- W2165290124 cites W2016515552 @default.
- W2165290124 cites W2017886031 @default.
- W2165290124 cites W2021109304 @default.
- W2165290124 cites W2023506714 @default.
- W2165290124 cites W2026005895 @default.
- W2165290124 cites W2026441283 @default.
- W2165290124 cites W2027111992 @default.
- W2165290124 cites W2029572863 @default.
- W2165290124 cites W2036467125 @default.
- W2165290124 cites W2038154256 @default.
- W2165290124 cites W2039905828 @default.
- W2165290124 cites W2040987875 @default.
- W2165290124 cites W2041698104 @default.
- W2165290124 cites W2046637313 @default.
- W2165290124 cites W2053695860 @default.
- W2165290124 cites W2053914489 @default.
- W2165290124 cites W2055326773 @default.
- W2165290124 cites W2058100090 @default.
- W2165290124 cites W2063358226 @default.
- W2165290124 cites W2069960987 @default.
- W2165290124 cites W2073724553 @default.
- W2165290124 cites W2081500927 @default.
- W2165290124 cites W2092532048 @default.
- W2165290124 cites W2093731483 @default.
- W2165290124 cites W2102742081 @default.
- W2165290124 cites W2105859090 @default.
- W2165290124 cites W2108822760 @default.
- W2165290124 cites W2110233921 @default.
- W2165290124 cites W2110277050 @default.
- W2165290124 cites W2116986357 @default.
- W2165290124 cites W2131350125 @default.
- W2165290124 cites W2136094046 @default.
- W2165290124 cites W2139186800 @default.
- W2165290124 cites W2145273873 @default.
- W2165290124 cites W2151554161 @default.
- W2165290124 cites W2151750070 @default.
- W2165290124 cites W2153453383 @default.
- W2165290124 cites W2156507140 @default.
- W2165290124 cites W2157025685 @default.
- W2165290124 cites W2157348056 @default.
- W2165290124 cites W2160166461 @default.
- W2165290124 cites W2223033079 @default.
- W2165290124 cites W2226489757 @default.
- W2165290124 cites W2288031839 @default.
- W2165290124 cites W2332077221 @default.
- W2165290124 cites W4249994485 @default.
- W2165290124 doi "https://doi.org/10.1091/mbc.e03-11-0788" @default.
- W2165290124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/515342" @default.
- W2165290124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15215309" @default.
- W2165290124 hasPublicationYear "2004" @default.
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