FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165346106> ?p ?o ?g. }

• W2165346106 endingPage "105" @default.
• W2165346106 startingPage "97" @default.
• W2165346106 abstract "In the vertebrate retina, vision is initiated and maintained by the photolysis and regeneration, respectively, of light-sensitive pigments in the disk membranes of the photoreceptor outer segments. This cyclical process depends on an exchange of retinoids between the photoreceptors and the retinal pigment epithelium (RPE). There is a great deal of indirect evidence that the transport of retinoids between these cellular compartments is mediated by the interphotoreceptor retinoid-binding protein (IRBP), a large glycoprotein synthesized in the photoreceptors and extruded into the interphotoreceptor matrix (IPM) that fills the subretinal space. Nevertheless, a number of in vitro experiments have demonstrated that an intermembranous transfer of retinoids can occur through an aqueous medium independent of any retinoid-binding protein. This led to the suggestion that IRBP may play the more passive role of an extracellular buffer, serving to prevent the degradation and potentially cytotoxic effects of free retinoids when large amounts are released into the IPM. We have studied the structural and functional properties of transgenic mice in which homologous recombination was used to delete the IRBP gene. Light- and electron-microscopic examination of the retinas of “knockout” ( IRBP−/− ) mice revealed a significant loss of photoreceptor nuclei, and profound changes in the structure and organization of the receptor outer segments. Consistent with these observations, electroretinographic recordings showed a marked reduction in response amplitude for both rod- and cone-mediated potentials. However, despite the histological and electrophysiological changes, there was no evidence of gross abnormalities in the visual cycle. After bleaching a significant fraction of the available rhodopsin, electroretinogram amplitude and rhodopsin density gradually increased toward their pre-bleach levels, and the rates of recovery were even more rapid than those seen in wild-type ( IRBP+/+ ) mice." @default.
• W2165346106 created "2016-06-24" @default.
• W2165346106 creator A5009861309 @default.
• W2165346106 creator A5018808867 @default.
• W2165346106 creator A5024900490 @default.
• W2165346106 creator A5030710435 @default.
• W2165346106 creator A5044459542 @default.
• W2165346106 creator A5064562354 @default.
• W2165346106 date "2000-01-01" @default.
• W2165346106 modified "2023-10-15" @default.
• W2165346106 title "The rhodopsin cycle is preserved in IRBP “knockout” mice despite abnormalities in retinal structure and function" @default.
• W2165346106 cites W1500561039 @default.
• W2165346106 cites W1503520330 @default.
• W2165346106 cites W1508509665 @default.
• W2165346106 cites W1546961042 @default.
• W2165346106 cites W1566249671 @default.
• W2165346106 cites W1589587808 @default.
• W2165346106 cites W1602141111 @default.
• W2165346106 cites W1973323482 @default.
• W2165346106 cites W1975075223 @default.
• W2165346106 cites W1975358267 @default.
• W2165346106 cites W1976071843 @default.
• W2165346106 cites W1980564071 @default.
• W2165346106 cites W1983237714 @default.
• W2165346106 cites W1986731294 @default.
• W2165346106 cites W1992632065 @default.
• W2165346106 cites W1993834457 @default.
• W2165346106 cites W1996897401 @default.
• W2165346106 cites W1997875633 @default.
• W2165346106 cites W2000890912 @default.
• W2165346106 cites W2013046627 @default.
• W2165346106 cites W2013238661 @default.
• W2165346106 cites W2022592544 @default.
• W2165346106 cites W2037715397 @default.
• W2165346106 cites W2044721940 @default.
• W2165346106 cites W204633197 @default.
• W2165346106 cites W2048188877 @default.
• W2165346106 cites W2051663781 @default.
• W2165346106 cites W2053786313 @default.
• W2165346106 cites W2054326088 @default.
• W2165346106 cites W205550050 @default.
• W2165346106 cites W2056618475 @default.
• W2165346106 cites W2066236105 @default.
• W2165346106 cites W2068593589 @default.
• W2165346106 cites W2069720648 @default.
• W2165346106 cites W2074007236 @default.
• W2165346106 cites W2083514652 @default.
• W2165346106 cites W2089245614 @default.
• W2165346106 cites W2113045051 @default.
• W2165346106 cites W2124179160 @default.
• W2165346106 cites W2137214612 @default.
• W2165346106 cites W2146216956 @default.
• W2165346106 cites W2150767772 @default.
• W2165346106 cites W2169090256 @default.
• W2165346106 cites W322662147 @default.
• W2165346106 cites W77349174 @default.
• W2165346106 cites W8728533 @default.
• W2165346106 cites W88214990 @default.
• W2165346106 doi "https://doi.org/10.1017/s095252380017110x" @default.
• W2165346106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10750831" @default.
• W2165346106 hasPublicationYear "2000" @default.
• W2165346106 type Work @default.
• W2165346106 sameAs 2165346106 @default.
• W2165346106 citedByCount "91" @default.
• W2165346106 countsByYear W21653461062012 @default.
• W2165346106 countsByYear W21653461062013 @default.
• W2165346106 countsByYear W21653461062014 @default.
• W2165346106 countsByYear W21653461062015 @default.
• W2165346106 countsByYear W21653461062016 @default.
• W2165346106 countsByYear W21653461062017 @default.
• W2165346106 countsByYear W21653461062018 @default.
• W2165346106 countsByYear W21653461062019 @default.
• W2165346106 countsByYear W21653461062020 @default.
• W2165346106 countsByYear W21653461062021 @default.
• W2165346106 countsByYear W21653461062023 @default.
• W2165346106 crossrefType "journal-article" @default.
• W2165346106 hasAuthorship W2165346106A5009861309 @default.
• W2165346106 hasAuthorship W2165346106A5018808867 @default.
• W2165346106 hasAuthorship W2165346106A5024900490 @default.
• W2165346106 hasAuthorship W2165346106A5030710435 @default.
• W2165346106 hasAuthorship W2165346106A5044459542 @default.
• W2165346106 hasAuthorship W2165346106A5064562354 @default.
• W2165346106 hasConcept C12554922 @default.
• W2165346106 hasConcept C131667965 @default.
• W2165346106 hasConcept C169760540 @default.
• W2165346106 hasConcept C189780591 @default.
• W2165346106 hasConcept C202033177 @default.
• W2165346106 hasConcept C2777093970 @default.
• W2165346106 hasConcept C2778024200 @default.
• W2165346106 hasConcept C2779113765 @default.
• W2165346106 hasConcept C2780827179 @default.
• W2165346106 hasConcept C2780916184 @default.
• W2165346106 hasConcept C2781040256 @default.
• W2165346106 hasConcept C55493867 @default.
• W2165346106 hasConcept C86803240 @default.
• W2165346106 hasConcept C95444343 @default.
• W2165346106 hasConceptScore W2165346106C12554922 @default.
• W2165346106 hasConceptScore W2165346106C131667965 @default.

• next