Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165348514> ?p ?o ?g. }
- W2165348514 endingPage "80" @default.
- W2165348514 startingPage "73" @default.
- W2165348514 abstract "Virus-like particles composed of the core antigen of hepatitis B virus (HBcAg) have been shown to be an effective platform for the display of foreign epitopes in vaccine development. Heterologous sequences have been successfully inserted at both amino and carboxy termini as well as internally at the major immunodominant epitope. We used cryogenic electron microscopy (CryoEM) and three-dimensional image reconstruction to investigate the structure of VLPs assembled from an N-terminal extended HBcAg that contained a polyhistidine tag. The insert was seen to form a trimeric spike on the capsid surface that was poorly resolved, most likely owing to it being flexible. We hypothesise that the capacity of N-terminal inserts to form trimers may have application in the development of multivalent vaccines to trimeric antigens. Our analysis also highlights the value of tools for local resolution assessment in studies of partially disordered macromolecular assemblies by cryoEM." @default.
- W2165348514 created "2016-06-24" @default.
- W2165348514 creator A5003625566 @default.
- W2165348514 creator A5009953091 @default.
- W2165348514 creator A5022405565 @default.
- W2165348514 creator A5027465036 @default.
- W2165348514 creator A5038820258 @default.
- W2165348514 creator A5062839464 @default.
- W2165348514 creator A5085876997 @default.
- W2165348514 date "2015-02-01" @default.
- W2165348514 modified "2023-10-16" @default.
- W2165348514 title "An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles" @default.
- W2165348514 cites W1530508980 @default.
- W2165348514 cites W1816167774 @default.
- W2165348514 cites W1816183039 @default.
- W2165348514 cites W1853664782 @default.
- W2165348514 cites W1970197953 @default.
- W2165348514 cites W1993518869 @default.
- W2165348514 cites W1995785876 @default.
- W2165348514 cites W2011093328 @default.
- W2165348514 cites W2011222991 @default.
- W2165348514 cites W2011582129 @default.
- W2165348514 cites W2012695091 @default.
- W2165348514 cites W2014391882 @default.
- W2165348514 cites W2015628141 @default.
- W2165348514 cites W2025212003 @default.
- W2165348514 cites W2025860397 @default.
- W2165348514 cites W2027977821 @default.
- W2165348514 cites W2029911509 @default.
- W2165348514 cites W2033389023 @default.
- W2165348514 cites W2033867130 @default.
- W2165348514 cites W2034484189 @default.
- W2165348514 cites W2038738042 @default.
- W2165348514 cites W2039706307 @default.
- W2165348514 cites W2048982317 @default.
- W2165348514 cites W2050066735 @default.
- W2165348514 cites W2053038074 @default.
- W2165348514 cites W2060914577 @default.
- W2165348514 cites W2061513932 @default.
- W2165348514 cites W2065729511 @default.
- W2165348514 cites W2080187599 @default.
- W2165348514 cites W2081444019 @default.
- W2165348514 cites W2086812659 @default.
- W2165348514 cites W2087627380 @default.
- W2165348514 cites W2097107156 @default.
- W2165348514 cites W2104130324 @default.
- W2165348514 cites W2104969243 @default.
- W2165348514 cites W2109913449 @default.
- W2165348514 cites W2116063606 @default.
- W2165348514 cites W2131288855 @default.
- W2165348514 cites W2132629607 @default.
- W2165348514 cites W2148483761 @default.
- W2165348514 cites W2152857843 @default.
- W2165348514 cites W2152986015 @default.
- W2165348514 cites W2158955459 @default.
- W2165348514 cites W2165102205 @default.
- W2165348514 cites W4229632899 @default.
- W2165348514 doi "https://doi.org/10.1016/j.jsb.2014.12.006" @default.
- W2165348514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4318616" @default.
- W2165348514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25557498" @default.
- W2165348514 hasPublicationYear "2015" @default.
- W2165348514 type Work @default.
- W2165348514 sameAs 2165348514 @default.
- W2165348514 citedByCount "8" @default.
- W2165348514 countsByYear W21653485142016 @default.
- W2165348514 countsByYear W21653485142017 @default.
- W2165348514 countsByYear W21653485142018 @default.
- W2165348514 countsByYear W21653485142020 @default.
- W2165348514 countsByYear W21653485142022 @default.
- W2165348514 countsByYear W21653485142023 @default.
- W2165348514 crossrefType "journal-article" @default.
- W2165348514 hasAuthorship W2165348514A5003625566 @default.
- W2165348514 hasAuthorship W2165348514A5009953091 @default.
- W2165348514 hasAuthorship W2165348514A5022405565 @default.
- W2165348514 hasAuthorship W2165348514A5027465036 @default.
- W2165348514 hasAuthorship W2165348514A5038820258 @default.
- W2165348514 hasAuthorship W2165348514A5062839464 @default.
- W2165348514 hasAuthorship W2165348514A5085876997 @default.
- W2165348514 hasBestOaLocation W21653485141 @default.
- W2165348514 hasConcept C104292427 @default.
- W2165348514 hasConcept C104317684 @default.
- W2165348514 hasConcept C12554922 @default.
- W2165348514 hasConcept C147483822 @default.
- W2165348514 hasConcept C159047783 @default.
- W2165348514 hasConcept C185592680 @default.
- W2165348514 hasConcept C195616568 @default.
- W2165348514 hasConcept C202878990 @default.
- W2165348514 hasConcept C20702342 @default.
- W2165348514 hasConcept C2522874641 @default.
- W2165348514 hasConcept C2777410769 @default.
- W2165348514 hasConcept C2779729466 @default.
- W2165348514 hasConcept C2780593183 @default.
- W2165348514 hasConcept C54355233 @default.
- W2165348514 hasConcept C55493867 @default.
- W2165348514 hasConcept C70721500 @default.
- W2165348514 hasConcept C8010536 @default.
- W2165348514 hasConcept C86803240 @default.
- W2165348514 hasConceptScore W2165348514C104292427 @default.