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- W2165364754 abstract "Long-distance transport of mRNAs is important in determining polarity in eukaryotes. Molecular motors shuttle large ribonucleoprotein complexes (mRNPs) containing RNA-binding proteins and associated factors along microtubules. However, precise mechanisms including the interplay of molecular motors and a potential connection to membrane trafficking remain elusive. Here, we solve the motor composition of transported mRNPs containing the RNA-binding protein Rrm4 of the pathogen Ustilago maydis. The underlying transport process determines the axis of polarity in infectious filaments. Plus-end-directed Kin3, a kinesin-3 type motor, mediates anterograde transport of mRNPs and is also present in transport units moving retrogradely. Split dynein Dyn1-Dyn2 functions in retrograde movement of mRNPs. Plus-end-directed conventional kinesin Kin1 is indirectly involved by transporting minus-end-directed dynein back to plus ends. Importantly, we additionally demonstrate that Rrm4-containing mRNPs colocalise with the t-SNARE Yup1 on shuttling endosomes and that functional endosomes are essential for mRNP movement. Either loss of Kin3 or removal of its lipid-binding pleckstrin-homology domain abolishes Rrm4-dependent movement without preventing colocalisation of Rrm4 and Yup1-positive endosomes. In summary, we uncovered the combination of motors required for mRNP shuttling along microtubules. Furthermore, intimately linked co-transport of endosomes and mRNPs suggests vesicle hitchhiking as mode of mRNP transport." @default.
- W2165364754 created "2016-06-24" @default.
- W2165364754 creator A5007372596 @default.
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- W2165364754 creator A5082243570 @default.
- W2165364754 date "2012-01-01" @default.
- W2165364754 modified "2023-10-13" @default.
- W2165364754 title "Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes" @default.
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- W2165364754 doi "https://doi.org/10.1242/jcs.101212" @default.
- W2165364754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22357951" @default.
- W2165364754 hasPublicationYear "2012" @default.
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