Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165370634> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2165370634 endingPage "728" @default.
- W2165370634 startingPage "724" @default.
- W2165370634 abstract "A total of 335 patients with early Parkinson's disease (PD) were enrolled in a multicenter, randomized, double-blind trial designed to assess the efficacy and safety of pramipexole. Entry was restricted to patients with idiopathic PD who were not receiving levodopa. Pramipexole was administered according to an ascending dose schedule up to 4.5 mg/d. During the 7-week dose-escalation phase, each subject was titrated to his or her maximally tolerated dose of study medication. This was followed by a 24-week period of maintenance therapy. The mean daily dose during the maintenance period was 3.8 mg. Pramipexole significantly reduced the severity of PD symptoms and signs compared with placebo, as measured by decreases in parts II (Activities of Daily Living) and III (Motor Examination) of the Unified Parkinson's Disease Rating Scale at week 24 compared with baseline ( p ≤ 0.0001). Differences between the active drug and placebo groups emerged at week 3 (1.5 mg/d) in the ascending-dose interval and persisted throughout the maintenance phase ( p ≤ 0.0001). The majority of patients completed the study (pramipexole 83%, placebo 80%). In the assessment of adverse events, nausea, insomnia, constipation, somnolence, and visual hallucinations occurred more frequently in the pramipexole treatment group compared with placebo patients. No clinically significant changes were noted in blood pressure or pulse rate. Overall, these results indicate that pramipexole is safe and effective in the treatment of early PD." @default.
- W2165370634 created "2016-06-24" @default.
- W2165370634 creator A5017236837 @default.
- W2165370634 creator A5080998608 @default.
- W2165370634 creator A5089423660 @default.
- W2165370634 date "1997-09-01" @default.
- W2165370634 modified "2023-10-15" @default.
- W2165370634 title "Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson's disease" @default.
- W2165370634 cites W1965969446 @default.
- W2165370634 cites W1996680168 @default.
- W2165370634 cites W2003032475 @default.
- W2165370634 cites W2012937455 @default.
- W2165370634 cites W2032689764 @default.
- W2165370634 cites W2035421391 @default.
- W2165370634 cites W2056198101 @default.
- W2165370634 cites W2077346344 @default.
- W2165370634 cites W2103595884 @default.
- W2165370634 cites W4249023646 @default.
- W2165370634 cites W2034279707 @default.
- W2165370634 doi "https://doi.org/10.1212/wnl.49.3.724" @default.
- W2165370634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9305331" @default.
- W2165370634 hasPublicationYear "1997" @default.
- W2165370634 type Work @default.
- W2165370634 sameAs 2165370634 @default.
- W2165370634 citedByCount "262" @default.
- W2165370634 countsByYear W21653706342012 @default.
- W2165370634 countsByYear W21653706342013 @default.
- W2165370634 countsByYear W21653706342014 @default.
- W2165370634 countsByYear W21653706342015 @default.
- W2165370634 countsByYear W21653706342016 @default.
- W2165370634 countsByYear W21653706342017 @default.
- W2165370634 countsByYear W21653706342018 @default.
- W2165370634 countsByYear W21653706342019 @default.
- W2165370634 countsByYear W21653706342020 @default.
- W2165370634 countsByYear W21653706342021 @default.
- W2165370634 countsByYear W21653706342022 @default.
- W2165370634 countsByYear W21653706342023 @default.
- W2165370634 crossrefType "journal-article" @default.
- W2165370634 hasAuthorship W2165370634A5017236837 @default.
- W2165370634 hasAuthorship W2165370634A5080998608 @default.
- W2165370634 hasAuthorship W2165370634A5089423660 @default.
- W2165370634 hasConcept C126322002 @default.
- W2165370634 hasConcept C142724271 @default.
- W2165370634 hasConcept C197934379 @default.
- W2165370634 hasConcept C204787440 @default.
- W2165370634 hasConcept C27081682 @default.
- W2165370634 hasConcept C2779034229 @default.
- W2165370634 hasConcept C2779134260 @default.
- W2165370634 hasConcept C2779734285 @default.
- W2165370634 hasConcept C2779989193 @default.
- W2165370634 hasConcept C2780304432 @default.
- W2165370634 hasConcept C2780580376 @default.
- W2165370634 hasConcept C42219234 @default.
- W2165370634 hasConcept C71924100 @default.
- W2165370634 hasConceptScore W2165370634C126322002 @default.
- W2165370634 hasConceptScore W2165370634C142724271 @default.
- W2165370634 hasConceptScore W2165370634C197934379 @default.
- W2165370634 hasConceptScore W2165370634C204787440 @default.
- W2165370634 hasConceptScore W2165370634C27081682 @default.
- W2165370634 hasConceptScore W2165370634C2779034229 @default.
- W2165370634 hasConceptScore W2165370634C2779134260 @default.
- W2165370634 hasConceptScore W2165370634C2779734285 @default.
- W2165370634 hasConceptScore W2165370634C2779989193 @default.
- W2165370634 hasConceptScore W2165370634C2780304432 @default.
- W2165370634 hasConceptScore W2165370634C2780580376 @default.
- W2165370634 hasConceptScore W2165370634C42219234 @default.
- W2165370634 hasConceptScore W2165370634C71924100 @default.
- W2165370634 hasIssue "3" @default.
- W2165370634 hasLocation W21653706341 @default.
- W2165370634 hasLocation W21653706342 @default.
- W2165370634 hasOpenAccess W2165370634 @default.
- W2165370634 hasPrimaryLocation W21653706341 @default.
- W2165370634 hasRelatedWork W1991783018 @default.
- W2165370634 hasRelatedWork W1995899111 @default.
- W2165370634 hasRelatedWork W2016533892 @default.
- W2165370634 hasRelatedWork W2028656651 @default.
- W2165370634 hasRelatedWork W2034882273 @default.
- W2165370634 hasRelatedWork W2039927990 @default.
- W2165370634 hasRelatedWork W2063979267 @default.
- W2165370634 hasRelatedWork W2105129455 @default.
- W2165370634 hasRelatedWork W2157823433 @default.
- W2165370634 hasRelatedWork W2159311047 @default.
- W2165370634 hasVolume "49" @default.
- W2165370634 isParatext "false" @default.
- W2165370634 isRetracted "false" @default.
- W2165370634 magId "2165370634" @default.
- W2165370634 workType "article" @default.