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- W2165378016 abstract "Background A well-defined, reproducible small animal model that allows quantitative assessment of musculotendinous changes would be desirable for investigations concerning rotator cuff pathology. Methods The supraspinatus tendon was released by osteotomy of the greater tuberosity in seven New Zealand rabbits. The musculotendinous unit was then allowed to retract during 6 weeks. Retraction was monitored with computed tomography (CT). At sacrifice, CT measurements of retraction were validated by measurement of the total length of the musculotendinous unit after sacrifice and by correlation with functional and structural properties of the musculotendinous unit at tendon release and at sacrifice. Results Mean (SD) retraction of the musculotendinous unit was 1.8 (0.2) cm on CT, precisely, and negatively correlated with the total length of the retracted musculotendinous unit at sacrifice ( r = –0.87, p = 0.011) but not significantly correlated with CT measurements of atrophy ( r = 0.20, p = 0.699) or fatty infiltration ( r = 0.13, p = 0.78). Mean (SD) muscle work decreased from 1.6 (0.23) Nm to 1.2 (1) Nm ( p = 0.056). Mean (SD) muscle fibre diameter decreased from 65 (10) μm to 48 (16) μm ( p = 0.063). This decrease was significantly correlated with the amount of fatty infiltration ( r = 0.79, p = 0.033). Discussion Tendon release using osteotomy of the rabbit greater tuberosity allows precise measurement of musculotendinous retraction and offers the possibility for functional muscular testing. Changes in the rabbit supraspinatus muscle caused by myotendinous retraction correspond to those observed in established sheep models." @default.
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- W2165378016 date "2012-04-01" @default.
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- W2165378016 title "A Modified Rabbit Model for Rotator Cuff Tendon Tears: Functional, Histological and Radiological Characteristics of the Supraspinatus Muscle" @default.
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- W2165378016 doi "https://doi.org/10.1111/j.1758-5740.2011.00170.x" @default.
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