FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165381003> ?p ?o ?g. }

• W2165381003 endingPage "2062" @default.
• W2165381003 startingPage "2047" @default.
• W2165381003 abstract "Cattle are a major reservoir for Shiga toxin-producing Escherichia coli O157 (STEC O157) and harbor multiple genetic subtypes that do not all associate with human disease. STEC O157 evolved from an E. coli O55:H7 progenitor; however, a lack of genome sequence has hindered investigations on the divergence of human- and/or cattle-associated subtypes. Our goals were to 1) identify nucleotide polymorphisms for STEC O157 genetic subtype detection, 2) determine the phylogeny of STEC O157 genetic subtypes using polymorphism-derived genotypes and a phage insertion typing system, and 3) compare polymorphism-derived genotypes identified in this study with pulsed field gel electrophoresis (PFGE), the current gold standard for evaluating STEC O157 diversity. Using 762 nucleotide polymorphisms that were originally identified through whole-genome sequencing of 189 STEC O157 human- and cattle-isolated strains, we genotyped a collection of 426 STEC O157 strains. Concatenated polymorphism alleles defined 175 genotypes that were tagged by a minimal set of 138 polymorphisms. Eight major lineages of STEC O157 were identified, of which cattle are a reservoir for seven. Two lineages regularly harbored by cattle accounted for the majority of human disease in this study, whereas another was rarely represented in humans and may have evolved toward reduced human virulence. Notably, cattle are not a known reservoir for E. coli O55:H7 or STEC O157:H− (the first lineage to diverge within the STEC O157 serogroup), which both cause human disease. This result calls into question how cattle may have originally acquired STEC O157. The polymorphism-derived genotypes identified in this study did not surpass PFGE diversity assessed by BlnI and XbaI digestions in a subset of 93 strains. However, our results show that they are highly effective in assessing the evolutionary relatedness of epidemiologically unrelated STEC O157 genetic subtypes, including those associated with the cattle reservoir and human disease." @default.
• W2165381003 created "2016-06-24" @default.
• W2165381003 creator A5003260011 @default.
• W2165381003 creator A5008677085 @default.
• W2165381003 creator A5019775154 @default.
• W2165381003 creator A5036717399 @default.
• W2165381003 creator A5037130492 @default.
• W2165381003 creator A5037678266 @default.
• W2165381003 creator A5044205264 @default.
• W2165381003 creator A5046338460 @default.
• W2165381003 creator A5063282076 @default.
• W2165381003 creator A5064402534 @default.
• W2165381003 creator A5064877723 @default.
• W2165381003 creator A5065030286 @default.
• W2165381003 date "2012-02-21" @default.
• W2165381003 modified "2023-09-24" @default.
• W2165381003 title "Phylogeny of Shiga Toxin-Producing Escherichia coli O157 Isolated from Cattle and Clinically Ill Humans" @default.
• W2165381003 cites W1544093580 @default.
• W2165381003 cites W1709361490 @default.
• W2165381003 cites W1747733046 @default.
• W2165381003 cites W1860937064 @default.
• W2165381003 cites W1902575090 @default.
• W2165381003 cites W1904815041 @default.
• W2165381003 cites W1914720622 @default.
• W2165381003 cites W1967229113 @default.
• W2165381003 cites W1967620589 @default.
• W2165381003 cites W1975310477 @default.
• W2165381003 cites W1991433118 @default.
• W2165381003 cites W1993562792 @default.
• W2165381003 cites W2003915689 @default.
• W2165381003 cites W2008931521 @default.
• W2165381003 cites W2013455871 @default.
• W2165381003 cites W2015090731 @default.
• W2165381003 cites W2029040533 @default.
• W2165381003 cites W2030526081 @default.
• W2165381003 cites W2031719990 @default.
• W2165381003 cites W2032703405 @default.
• W2165381003 cites W2035757968 @default.
• W2165381003 cites W2040764710 @default.
• W2165381003 cites W2043832246 @default.
• W2165381003 cites W2045765967 @default.
• W2165381003 cites W2047346285 @default.
• W2165381003 cites W2050180599 @default.
• W2165381003 cites W2052541358 @default.
• W2165381003 cites W2069281061 @default.
• W2165381003 cites W2069753679 @default.
• W2165381003 cites W2071951949 @default.
• W2165381003 cites W2072641344 @default.
• W2165381003 cites W2072644999 @default.
• W2165381003 cites W2076363089 @default.
• W2165381003 cites W2078151980 @default.
• W2165381003 cites W2091708538 @default.
• W2165381003 cites W2092058570 @default.
• W2165381003 cites W2096810787 @default.
• W2165381003 cites W2097382368 @default.
• W2165381003 cites W2099836442 @default.
• W2165381003 cites W2107400489 @default.
• W2165381003 cites W2108126963 @default.
• W2165381003 cites W2110285283 @default.
• W2165381003 cites W2110739830 @default.
• W2165381003 cites W2112740026 @default.
• W2165381003 cites W2113709405 @default.
• W2165381003 cites W2115698620 @default.
• W2165381003 cites W2118512642 @default.
• W2165381003 cites W2119261996 @default.
• W2165381003 cites W2120401977 @default.
• W2165381003 cites W2120928099 @default.
• W2165381003 cites W2121713277 @default.
• W2165381003 cites W2131057932 @default.
• W2165381003 cites W2132032409 @default.
• W2165381003 cites W2139405511 @default.
• W2165381003 cites W2142602222 @default.
• W2165381003 cites W2148472678 @default.
• W2165381003 cites W2149459245 @default.
• W2165381003 cites W2149572296 @default.
• W2165381003 cites W2150463741 @default.
• W2165381003 cites W2151094267 @default.
• W2165381003 cites W2156196972 @default.
• W2165381003 cites W2159227713 @default.
• W2165381003 cites W2162530578 @default.
• W2165381003 cites W2169880557 @default.
• W2165381003 cites W2170996473 @default.
• W2165381003 cites W2764803392 @default.
• W2165381003 cites W4231234810 @default.
• W2165381003 cites W4295850018 @default.
• W2165381003 doi "https://doi.org/10.1093/molbev/mss072" @default.
• W2165381003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3408066" @default.
• W2165381003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22355013" @default.
• W2165381003 hasPublicationYear "2012" @default.
• W2165381003 type Work @default.
• W2165381003 sameAs 2165381003 @default.
• W2165381003 citedByCount "48" @default.
• W2165381003 countsByYear W21653810032012 @default.
• W2165381003 countsByYear W21653810032013 @default.
• W2165381003 countsByYear W21653810032014 @default.
• W2165381003 countsByYear W21653810032015 @default.
• W2165381003 countsByYear W21653810032016 @default.
• W2165381003 countsByYear W21653810032017 @default.

• next