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- W2165389026 abstract "A total of 216 99mTc-pertechnetate-sialographies, by applying stimulations by citric acid, were performed for studying radiation effects on the salivary glands in 145 patients. From a scintigram of the salivary gland, the time-activity-curves were obtained for analysis of salivary function. The shape of the time-activity-curve with respect to stimulus-response pattern was classified into four types according to the degree of radiation-induced dysfunction. We found that the acid stimulation was enhancing accumulation of the isotope into the salivary gland as well as influencing salivary discharge. A ratio (Rc) of pre- and post-stimulation counts permitted a construction of quantitative dose-response curves; the curve for the parotids had a slight rise of Rc's over 0–20 Gy, whereas that for the submandibular glands had a significant rise over 10–30 Gy; in both glands the rise of Rc's was followed by a steep fall. The parotids appeared to be more sensitive to radiation than the submandibular glands at 0–3 months following 20–70 Gy, but after 3 months both glands were similarly impaired. The gland volume irradiated was also of great importance in determining the degree of salivary dysfunction. The maximum uptakes averaged per unit area (salivary-to-background ratio) and determined during the initial 30 minutes were greater in the submandibular than in the parotid glands following >20 Gy. In both glands the maximum uptakes were gradually impaired with time over 3–36 months following 50–70 Gy." @default.
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- W2165389026 date "1985-09-01" @default.
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- W2165389026 title "Quantitative dose-response analysis of salivary function following radiotherapy using sequential RI-sialography" @default.
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- W2165389026 doi "https://doi.org/10.1016/0360-3016(85)90212-3" @default.
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