FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165413853> ?p ?o ?g. }

• W2165413853 endingPage "1151" @default.
• W2165413853 startingPage "1141" @default.
• W2165413853 abstract "BackgroundMenarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women.MethodsIndividual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression.FindingsBreast cancer risk increased by a factor of 1·050 (95% CI 1·044–1·057; p<0·0001) for every year younger at menarche, and independently by a smaller amount (1·029, 1·025–1·032; p<0·0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45–54 years 1·43, 1·33–1·52, p<0·001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0·006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0·01 for both comparisons).InterpretationThe effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.FundingCancer Research UK. Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Breast cancer risk increased by a factor of 1·050 (95% CI 1·044–1·057; p<0·0001) for every year younger at menarche, and independently by a smaller amount (1·029, 1·025–1·032; p<0·0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45–54 years 1·43, 1·33–1·52, p<0·001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p<0·006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p<0·01 for both comparisons). The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours." @default.
• W2165413853 created "2016-06-24" @default.
• W2165413853 creator A5000072069 @default.
• W2165413853 creator A5000877350 @default.
• W2165413853 creator A5000962812 @default.
• W2165413853 creator A5001086537 @default.
• W2165413853 creator A5002029455 @default.
• W2165413853 creator A5002176316 @default.
• W2165413853 creator A5002339556 @default.
• W2165413853 creator A5002422726 @default.
• W2165413853 creator A5002942437 @default.
• W2165413853 creator A5003226234 @default.
• W2165413853 creator A5003522548 @default.
• W2165413853 creator A5003866247 @default.
• W2165413853 creator A5004137241 @default.
• W2165413853 creator A5004532336 @default.
• W2165413853 creator A5004673405 @default.
• W2165413853 creator A5004881307 @default.
• W2165413853 creator A5005351223 @default.
• W2165413853 creator A5005624028 @default.
• W2165413853 creator A5006351544 @default.
• W2165413853 creator A5006585914 @default.
• W2165413853 creator A5006696926 @default.
• W2165413853 creator A5006926217 @default.
• W2165413853 creator A5007047047 @default.
• W2165413853 creator A5007491000 @default.
• W2165413853 creator A5007596794 @default.
• W2165413853 creator A5007954494 @default.
• W2165413853 creator A5007964616 @default.
• W2165413853 creator A5008062922 @default.
• W2165413853 creator A5008373933 @default.
• W2165413853 creator A5008821498 @default.
• W2165413853 creator A5009524646 @default.
• W2165413853 creator A5009636199 @default.
• W2165413853 creator A5009902913 @default.
• W2165413853 creator A5009970524 @default.
• W2165413853 creator A5010084842 @default.
• W2165413853 creator A5010111465 @default.
• W2165413853 creator A5010268595 @default.
• W2165413853 creator A5011150425 @default.
• W2165413853 creator A5011577313 @default.
• W2165413853 creator A5012051513 @default.
• W2165413853 creator A5012207888 @default.
• W2165413853 creator A5012309432 @default.
• W2165413853 creator A5012575502 @default.
• W2165413853 creator A5013210130 @default.
• W2165413853 creator A5013699285 @default.
• W2165413853 creator A5013826343 @default.
• W2165413853 creator A5014329282 @default.
• W2165413853 creator A5014353718 @default.
• W2165413853 creator A5014928396 @default.
• W2165413853 creator A5015244902 @default.
• W2165413853 creator A5015311047 @default.
• W2165413853 creator A5015817548 @default.
• W2165413853 creator A5016169570 @default.
• W2165413853 creator A5016194153 @default.
• W2165413853 creator A5016473306 @default.
• W2165413853 creator A5016769319 @default.
• W2165413853 creator A5016958524 @default.
• W2165413853 creator A5017031469 @default.
• W2165413853 creator A5017304245 @default.
• W2165413853 creator A5017514284 @default.
• W2165413853 creator A5017595492 @default.
• W2165413853 creator A5018904268 @default.
• W2165413853 creator A5019070324 @default.
• W2165413853 creator A5019116290 @default.
• W2165413853 creator A5019207040 @default.
• W2165413853 creator A5019467370 @default.
• W2165413853 creator A5019496865 @default.
• W2165413853 creator A5020186359 @default.
• W2165413853 creator A5020208883 @default.
• W2165413853 creator A5020564648 @default.
• W2165413853 creator A5020720349 @default.
• W2165413853 creator A5021032223 @default.
• W2165413853 creator A5021475121 @default.
• W2165413853 creator A5021761022 @default.
• W2165413853 creator A5021988049 @default.
• W2165413853 creator A5022206898 @default.
• W2165413853 creator A5022375184 @default.
• W2165413853 creator A5022647677 @default.
• W2165413853 creator A5023057919 @default.
• W2165413853 creator A5023179121 @default.
• W2165413853 creator A5023525584 @default.
• W2165413853 creator A5023667273 @default.
• W2165413853 creator A5023978743 @default.
• W2165413853 creator A5024241356 @default.
• W2165413853 creator A5024793534 @default.
• W2165413853 creator A5024881798 @default.
• W2165413853 creator A5025402303 @default.
• W2165413853 creator A5025516591 @default.
• W2165413853 creator A5026058383 @default.
• W2165413853 creator A5026285947 @default.
• W2165413853 creator A5026483257 @default.
• W2165413853 creator A5026590695 @default.
• W2165413853 creator A5027517833 @default.
• W2165413853 creator A5027534140 @default.
• W2165413853 creator A5028102125 @default.
• W2165413853 creator A5028352370 @default.

• next