FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165424279> ?p ?o ?g. }

• W2165424279 endingPage "649" @default.
• W2165424279 startingPage "642" @default.
• W2165424279 abstract "Hypertension is associated with cardiac noradrenergic hyperactivity, although it is not clear whether this precedes or follows the development of hypertension itself. We hypothesized that Ca(2+) homeostasis in postganglionic sympathetic neurons is impaired in spontaneously hypertensive rats (SHRs) and may occur before the development of hypertension. The depolarization-induced rise in intracellular free calcium concentration ([Ca(2+)](i); measured using fura-2-acetoxymethyl ester) was significantly larger in cultured sympathetic neurons from prehypertensive SHRs than in age matched normotensive Wistar-Kyoto rats. The decay of the [Ca(2+)](i) transient was also faster in SHRs. The endoplasmic reticulum Ca(2+) content and caffeine-induced [Ca(2+)](i) amplitude were significantly greater in the young SHRs. Lower protein levels of phospholamban and more copies of ryanodine receptor mRNA were also observed in the young SHRs. Depleting the endoplasmic reticulum Ca(2+) store did not alter the difference of the evoked [Ca(2+)](i) transient and decay time between young SHRs and Wistar-Kyoto rats. However, removing mitochondrial Ca(2+) buffering abolished these differences. A lower mitochondrial membrane potential was also observed in young SHR sympathetic neurons. This resulted in impaired mitochondrial Ca(2+) uptake and release, which might partly be responsible for the increased [Ca(2+)](i) transient and faster decay in SHR sympathetic neurons. This Ca(2+) phenotype seen in early development in cardiac stellate and superior cervical ganglion neurons may contribute to the sympathetic hyperresponsiveness that precedes the onset of hypertension." @default.
• W2165424279 created "2016-06-24" @default.
• W2165424279 creator A5019179543 @default.
• W2165424279 creator A5038851564 @default.
• W2165424279 creator A5054059116 @default.
• W2165424279 creator A5063142563 @default.
• W2165424279 creator A5070224675 @default.
• W2165424279 creator A5084312738 @default.
• W2165424279 date "2012-03-01" @default.
• W2165424279 modified "2023-10-16" @default.
• W2165424279 title "Abnormal Intracellular Calcium Homeostasis in Sympathetic Neurons From Young Prehypertensive Rats" @default.
• W2165424279 cites W1965412716 @default.
• W2165424279 cites W1965559087 @default.
• W2165424279 cites W1968826589 @default.
• W2165424279 cites W1970102548 @default.
• W2165424279 cites W1972825005 @default.
• W2165424279 cites W1973379750 @default.
• W2165424279 cites W1986124091 @default.
• W2165424279 cites W1986690550 @default.
• W2165424279 cites W1996255031 @default.
• W2165424279 cites W1999054629 @default.
• W2165424279 cites W2001261464 @default.
• W2165424279 cites W2006368108 @default.
• W2165424279 cites W2013455339 @default.
• W2165424279 cites W2015131505 @default.
• W2165424279 cites W2022263701 @default.
• W2165424279 cites W2027215774 @default.
• W2165424279 cites W2028268335 @default.
• W2165424279 cites W2039509384 @default.
• W2165424279 cites W2041714371 @default.
• W2165424279 cites W2041964617 @default.
• W2165424279 cites W2045307498 @default.
• W2165424279 cites W2054315986 @default.
• W2165424279 cites W2064722489 @default.
• W2165424279 cites W2076420512 @default.
• W2165424279 cites W2086999698 @default.
• W2165424279 cites W2087053197 @default.
• W2165424279 cites W2091103166 @default.
• W2165424279 cites W2095352259 @default.
• W2165424279 cites W2107092259 @default.
• W2165424279 cites W2109070559 @default.
• W2165424279 cites W2113621206 @default.
• W2165424279 cites W2125281293 @default.
• W2165424279 cites W2126198463 @default.
• W2165424279 cites W2127710597 @default.
• W2165424279 cites W2152106298 @default.
• W2165424279 cites W2162025110 @default.
• W2165424279 cites W2166666996 @default.
• W2165424279 cites W4255760236 @default.
• W2165424279 cites W58055601 @default.
• W2165424279 doi "https://doi.org/10.1161/hypertensionaha.111.186460" @default.
• W2165424279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3299568" @default.
• W2165424279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22252398" @default.
• W2165424279 hasPublicationYear "2012" @default.
• W2165424279 type Work @default.
• W2165424279 sameAs 2165424279 @default.
• W2165424279 citedByCount "48" @default.
• W2165424279 countsByYear W21654242792013 @default.
• W2165424279 countsByYear W21654242792015 @default.
• W2165424279 countsByYear W21654242792016 @default.
• W2165424279 countsByYear W21654242792017 @default.
• W2165424279 countsByYear W21654242792018 @default.
• W2165424279 countsByYear W21654242792019 @default.
• W2165424279 countsByYear W21654242792020 @default.
• W2165424279 countsByYear W21654242792021 @default.
• W2165424279 countsByYear W21654242792022 @default.
• W2165424279 countsByYear W21654242792023 @default.
• W2165424279 crossrefType "journal-article" @default.
• W2165424279 hasAuthorship W2165424279A5019179543 @default.
• W2165424279 hasAuthorship W2165424279A5038851564 @default.
• W2165424279 hasAuthorship W2165424279A5054059116 @default.
• W2165424279 hasAuthorship W2165424279A5063142563 @default.
• W2165424279 hasAuthorship W2165424279A5070224675 @default.
• W2165424279 hasAuthorship W2165424279A5084312738 @default.
• W2165424279 hasBestOaLocation W21654242791 @default.
• W2165424279 hasConcept C113217602 @default.
• W2165424279 hasConcept C126322002 @default.
• W2165424279 hasConcept C134018914 @default.
• W2165424279 hasConcept C158617107 @default.
• W2165424279 hasConcept C17137333 @default.
• W2165424279 hasConcept C181199279 @default.
• W2165424279 hasConcept C185592680 @default.
• W2165424279 hasConcept C23265538 @default.
• W2165424279 hasConcept C2781414619 @default.
• W2165424279 hasConcept C519063684 @default.
• W2165424279 hasConcept C55493867 @default.
• W2165424279 hasConcept C63645605 @default.
• W2165424279 hasConcept C71924100 @default.
• W2165424279 hasConcept C86803240 @default.
• W2165424279 hasConcept C95444343 @default.
• W2165424279 hasConceptScore W2165424279C113217602 @default.
• W2165424279 hasConceptScore W2165424279C126322002 @default.
• W2165424279 hasConceptScore W2165424279C134018914 @default.
• W2165424279 hasConceptScore W2165424279C158617107 @default.
• W2165424279 hasConceptScore W2165424279C17137333 @default.
• W2165424279 hasConceptScore W2165424279C181199279 @default.
• W2165424279 hasConceptScore W2165424279C185592680 @default.
• W2165424279 hasConceptScore W2165424279C23265538 @default.

• next