FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165424802> ?p ?o ?g. }

• W2165424802 endingPage "2956" @default.
• W2165424802 startingPage "2948" @default.
• W2165424802 abstract "Abstract In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived population. We show here that these novel intrathymic DCs are truly myeloid, as they arise from CD34+ early thymic progenitors through CD34lointermediates which have lost the capacity to generate T cells, but display myelomonocytic differentiation potential. We also demonstrate that phenotypically and functionally equivalent myeloid precursors devoid of T-cell potential do exist in vivo in the postnatal thymus. Moreover, although interleukin 7 (IL-7) supports the generation of such myeloid intermediates, we show that their developmental branching from the main intrathymic T-cell pathway is linked to the up-regulation of the myelomonocytic granulocyte macrophage–colony-stimulating factor (GM-CSF) receptor, to the down-regulation of the IL-7 receptor and to the lack of pre–T-cell receptor α (pTα) gene transcriptional activation. Taken together, these data challenge the current view that the thymus is colonized by a lymphoid-restricted progenitor and provide evidence that a more immature precursor population with lymphoid and myelomonocytic potential is actually seeding the human postnatal thymus." @default.
• W2165424802 created "2016-06-24" @default.
• W2165424802 creator A5010713127 @default.
• W2165424802 creator A5025114136 @default.
• W2165424802 creator A5044151726 @default.
• W2165424802 creator A5083181264 @default.
• W2165424802 date "2002-04-15" @default.
• W2165424802 modified "2023-10-01" @default.
• W2165424802 title "Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophage–colony-stimulating factor receptor" @default.
• W2165424802 cites W1479925906 @default.
• W2165424802 cites W1531474592 @default.
• W2165424802 cites W153394692 @default.
• W2165424802 cites W1617267715 @default.
• W2165424802 cites W1633413575 @default.
• W2165424802 cites W1661544713 @default.
• W2165424802 cites W1964458227 @default.
• W2165424802 cites W1975463463 @default.
• W2165424802 cites W1991876285 @default.
• W2165424802 cites W2007761469 @default.
• W2165424802 cites W2013284769 @default.
• W2165424802 cites W2022807359 @default.
• W2165424802 cites W2028092080 @default.
• W2165424802 cites W2028261045 @default.
• W2165424802 cites W2031170359 @default.
• W2165424802 cites W2039706096 @default.
• W2165424802 cites W2040212698 @default.
• W2165424802 cites W2058381744 @default.
• W2165424802 cites W2060405001 @default.
• W2165424802 cites W2078957773 @default.
• W2165424802 cites W2095016279 @default.
• W2165424802 cites W2096397910 @default.
• W2165424802 cites W2106241062 @default.
• W2165424802 cites W2108207978 @default.
• W2165424802 cites W2111220263 @default.
• W2165424802 cites W2121236896 @default.
• W2165424802 cites W2131761283 @default.
• W2165424802 cites W2142356948 @default.
• W2165424802 cites W2149939821 @default.
• W2165424802 cites W2156423848 @default.
• W2165424802 cites W2156498845 @default.
• W2165424802 cites W2158913853 @default.
• W2165424802 cites W2161792071 @default.
• W2165424802 cites W2167366928 @default.
• W2165424802 cites W2171418655 @default.
• W2165424802 cites W2231583054 @default.
• W2165424802 cites W2402443265 @default.
• W2165424802 cites W2419520498 @default.
• W2165424802 cites W242181897 @default.
• W2165424802 cites W4252805733 @default.
• W2165424802 doi "https://doi.org/10.1182/blood.v99.8.2948" @default.
• W2165424802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11929786" @default.
• W2165424802 hasPublicationYear "2002" @default.
• W2165424802 type Work @default.
• W2165424802 sameAs 2165424802 @default.
• W2165424802 citedByCount "39" @default.
• W2165424802 countsByYear W21654248022012 @default.
• W2165424802 countsByYear W21654248022013 @default.
• W2165424802 countsByYear W21654248022014 @default.
• W2165424802 countsByYear W21654248022015 @default.
• W2165424802 countsByYear W21654248022017 @default.
• W2165424802 countsByYear W21654248022018 @default.
• W2165424802 countsByYear W21654248022022 @default.
• W2165424802 countsByYear W21654248022023 @default.
• W2165424802 crossrefType "journal-article" @default.
• W2165424802 hasAuthorship W2165424802A5010713127 @default.
• W2165424802 hasAuthorship W2165424802A5025114136 @default.
• W2165424802 hasAuthorship W2165424802A5044151726 @default.
• W2165424802 hasAuthorship W2165424802A5083181264 @default.
• W2165424802 hasBestOaLocation W21654248021 @default.
• W2165424802 hasConcept C131665280 @default.
• W2165424802 hasConcept C201750760 @default.
• W2165424802 hasConcept C203014093 @default.
• W2165424802 hasConcept C2776090121 @default.
• W2165424802 hasConcept C2777478134 @default.
• W2165424802 hasConcept C2778170410 @default.
• W2165424802 hasConcept C2778690821 @default.
• W2165424802 hasConcept C2779282312 @default.
• W2165424802 hasConcept C28328180 @default.
• W2165424802 hasConcept C2908647359 @default.
• W2165424802 hasConcept C502942594 @default.
• W2165424802 hasConcept C67662055 @default.
• W2165424802 hasConcept C71924100 @default.
• W2165424802 hasConcept C86803240 @default.
• W2165424802 hasConcept C8891405 @default.
• W2165424802 hasConcept C95444343 @default.
• W2165424802 hasConcept C99454951 @default.
• W2165424802 hasConceptScore W2165424802C131665280 @default.
• W2165424802 hasConceptScore W2165424802C201750760 @default.
• W2165424802 hasConceptScore W2165424802C203014093 @default.
• W2165424802 hasConceptScore W2165424802C2776090121 @default.
• W2165424802 hasConceptScore W2165424802C2777478134 @default.
• W2165424802 hasConceptScore W2165424802C2778170410 @default.
• W2165424802 hasConceptScore W2165424802C2778690821 @default.
• W2165424802 hasConceptScore W2165424802C2779282312 @default.
• W2165424802 hasConceptScore W2165424802C28328180 @default.
• W2165424802 hasConceptScore W2165424802C2908647359 @default.
• W2165424802 hasConceptScore W2165424802C502942594 @default.
• W2165424802 hasConceptScore W2165424802C67662055 @default.

• next