FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165427652> ?p ?o ?g. }

• W2165427652 endingPage "7" @default.
• W2165427652 startingPage "1" @default.
• W2165427652 abstract "Psoralea corylifolia L. (Fabaceae) is a widely used medical plant in China. This study was designed to screen and identify bioactive compounds with anticancer activity from the seeds of Psoralea corylifolia L. One volatile fraction (fraction I) and three other fractions (fraction II, III, IV) from methanol extraction of P. corylifolia L. were obtained. Bioactivities of these fractions were evaluated by the cytotoxicity on KB, KBv200, K562, K562/ADM cancer cells with MTT assay. Major components in the active fraction were identified by HPLC/MS(n). Fraction IV significantly inhibits the growth of cancer cells in a dose-dependent manner. The IC(50) values were 21.6, 24.4, 10.0 and 26.9, respectively. Psoralen and isopsoralen, isolated from fraction IV, were subject to bioactive assay and presented a dose-dependent anticancer activity in four cancer cell lines (KB, KBv200, K562 and K562/ADM). The IC(50) values of psoralen were 88.1, 86.6, 24.4 and 62.6, which of isopsoralen were 61.9, 49.4, 49.6 and 72.0, respectively. Apoptosis of tumor cell significantly increased after treated with psoralen and isopsoralen. Induction of apoptotic activity was confirmed by flow cytometry after staining with Annexin V/PI. These results suggested psoralen and isopsoralen contribute to anticancer effect of P. corylifolia L." @default.
• W2165427652 created "2016-06-24" @default.
• W2165427652 creator A5029667848 @default.
• W2165427652 creator A5032449956 @default.
• W2165427652 creator A5063129814 @default.
• W2165427652 creator A5076841551 @default.
• W2165427652 creator A5080652074 @default.
• W2165427652 date "2011-01-01" @default.
• W2165427652 modified "2023-10-16" @default.
• W2165427652 title "Screening Antitumor Compounds Psoralen and Isopsoralen from<i>Psoralea corylifolia</i>L. Seeds" @default.
• W2165427652 cites W147439079 @default.
• W2165427652 cites W1979889094 @default.
• W2165427652 cites W1984297788 @default.
• W2165427652 cites W1986379404 @default.
• W2165427652 cites W1991207634 @default.
• W2165427652 cites W2013372525 @default.
• W2165427652 cites W2014383571 @default.
• W2165427652 cites W2023055150 @default.
• W2165427652 cites W2025549328 @default.
• W2165427652 cites W2038758867 @default.
• W2165427652 cites W2049855636 @default.
• W2165427652 cites W2067727488 @default.
• W2165427652 cites W2074655217 @default.
• W2165427652 cites W2085414423 @default.
• W2165427652 cites W2110793224 @default.
• W2165427652 cites W2111669208 @default.
• W2165427652 cites W2113377751 @default.
• W2165427652 cites W2113596478 @default.
• W2165427652 cites W2124360025 @default.
• W2165427652 cites W2140655085 @default.
• W2165427652 cites W2143213665 @default.
• W2165427652 cites W2150138923 @default.
• W2165427652 doi "https://doi.org/10.1093/ecam/nen087" @default.
• W2165427652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3135392" @default.
• W2165427652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19131395" @default.
• W2165427652 hasPublicationYear "2011" @default.
• W2165427652 type Work @default.
• W2165427652 sameAs 2165427652 @default.
• W2165427652 citedByCount "91" @default.
• W2165427652 countsByYear W21654276522012 @default.
• W2165427652 countsByYear W21654276522013 @default.
• W2165427652 countsByYear W21654276522014 @default.
• W2165427652 countsByYear W21654276522015 @default.
• W2165427652 countsByYear W21654276522016 @default.
• W2165427652 countsByYear W21654276522017 @default.
• W2165427652 countsByYear W21654276522018 @default.
• W2165427652 countsByYear W21654276522019 @default.
• W2165427652 countsByYear W21654276522020 @default.
• W2165427652 countsByYear W21654276522021 @default.
• W2165427652 countsByYear W21654276522022 @default.
• W2165427652 countsByYear W21654276522023 @default.
• W2165427652 crossrefType "journal-article" @default.
• W2165427652 hasAuthorship W2165427652A5029667848 @default.
• W2165427652 hasAuthorship W2165427652A5032449956 @default.
• W2165427652 hasAuthorship W2165427652A5063129814 @default.
• W2165427652 hasAuthorship W2165427652A5076841551 @default.
• W2165427652 hasAuthorship W2165427652A5080652074 @default.
• W2165427652 hasBestOaLocation W21654276521 @default.
• W2165427652 hasConcept C109316439 @default.
• W2165427652 hasConcept C142724271 @default.
• W2165427652 hasConcept C185592680 @default.
• W2165427652 hasConcept C190283241 @default.
• W2165427652 hasConcept C202751555 @default.
• W2165427652 hasConcept C204787440 @default.
• W2165427652 hasConcept C2779855038 @default.
• W2165427652 hasConcept C2780783641 @default.
• W2165427652 hasConcept C2781110370 @default.
• W2165427652 hasConcept C552990157 @default.
• W2165427652 hasConcept C55493867 @default.
• W2165427652 hasConcept C556039675 @default.
• W2165427652 hasConcept C71924100 @default.
• W2165427652 hasConceptScore W2165427652C109316439 @default.
• W2165427652 hasConceptScore W2165427652C142724271 @default.
• W2165427652 hasConceptScore W2165427652C185592680 @default.
• W2165427652 hasConceptScore W2165427652C190283241 @default.
• W2165427652 hasConceptScore W2165427652C202751555 @default.
• W2165427652 hasConceptScore W2165427652C204787440 @default.
• W2165427652 hasConceptScore W2165427652C2779855038 @default.
• W2165427652 hasConceptScore W2165427652C2780783641 @default.
• W2165427652 hasConceptScore W2165427652C2781110370 @default.
• W2165427652 hasConceptScore W2165427652C552990157 @default.
• W2165427652 hasConceptScore W2165427652C55493867 @default.
• W2165427652 hasConceptScore W2165427652C556039675 @default.
• W2165427652 hasConceptScore W2165427652C71924100 @default.
• W2165427652 hasLocation W21654276521 @default.
• W2165427652 hasLocation W21654276522 @default.
• W2165427652 hasLocation W21654276523 @default.
• W2165427652 hasLocation W21654276524 @default.
• W2165427652 hasLocation W21654276525 @default.
• W2165427652 hasOpenAccess W2165427652 @default.
• W2165427652 hasPrimaryLocation W21654276521 @default.
• W2165427652 hasRelatedWork W1994632267 @default.
• W2165427652 hasRelatedWork W2006922785 @default.
• W2165427652 hasRelatedWork W2041351646 @default.
• W2165427652 hasRelatedWork W2118979375 @default.
• W2165427652 hasRelatedWork W2165427652 @default.
• W2165427652 hasRelatedWork W2354942646 @default.
• W2165427652 hasRelatedWork W2357115590 @default.

• next