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• W2165440779 abstract "We report single-point mutations that are located in the matrix protein domain of the gag gene of human immunodeficiency virus type 1 and that prevent Gag particle formation. We show that mutations of p17 that abolish human immunodeficiency virus particle assembly also prevent the dimerization of p17 protein, as measured directly by a protein-protein binding assay. In the three-dimensional structure of p17, mutations that abolish dimerization are located in a single alpha helix that forms part of a fingerlike projection from one side of the molecule. Peptides derived from this region of p17 also reduce the level of p17 dimer when they are added to p17-expressing cells and compete for p17 self-association when present in protein-protein binding assays. We propose that the dimerization of the Gag precursor that occurs by the interdigitation of alpha helices on adjacent matrix molecules is a key stage in virion assembly and that the prevention of such an interaction is the molecular basis of particle misassembly." @default.
• W2165440779 created "2016-06-24" @default.
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• W2165440779 date "1995-07-01" @default.
• W2165440779 modified "2023-09-27" @default.
• W2165440779 title "A molecular determinant of human immunodeficiency virus particle assembly located in matrix antigen p17" @default.
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• W2165440779 doi "https://doi.org/10.1128/jvi.69.7.4519-4523.1995" @default.
• W2165440779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/189197" @default.
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• W2165440779 hasPublicationYear "1995" @default.
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