Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165441808> ?p ?o ?g. }
- W2165441808 endingPage "558" @default.
- W2165441808 startingPage "550" @default.
- W2165441808 abstract "Smooth muscle cell (SMC) proliferation is a critical process in vascular disease. Heparan sulfate (HS) proteoglycans inhibit SMC growth, but the role of endogenous counterparts in the vessel wall in control of SMC function is not known in detail. Perlecan is the major HS proteoglycans in SMC basement membranes and in vessel wall extracellular matrix (ECM). In this study, transgenic mice with HS-deficient perlecan were analyzed with respect to vascular phenotype and intimal lesion formation. Furthermore, SMC cultures were established and characterized with respect to morphology, immunocytochemical features, proteoglycan synthesis, proliferative capacity, and ECM binding of basic fibroblast growth factor (FGF-2). In vitro, mutant SMCs formed basement membranes with perlecan core protein, but with decreased levels of HS, they showed diminished secretion of HS-containing perlecan into the medium and a defective ECM-binding capacity of FGF-2. In vitro, mutant SMCs showed increased proliferation compared with wild-type cells, and in vivo, enhanced SMC proliferation and intimal hyperplasia were observed after flow cessation of the carotid artery in mutant mice. The results indicate that the endogenous HS side-chains of perlecan contribute to SMC growth control both in vitro and during intimal hyperplasia, possibly by sequestering heparin-binding mitogens such as FGF-2." @default.
- W2165441808 created "2016-06-24" @default.
- W2165441808 creator A5000224317 @default.
- W2165441808 creator A5012025016 @default.
- W2165441808 creator A5019555799 @default.
- W2165441808 creator A5030429057 @default.
- W2165441808 creator A5064457105 @default.
- W2165441808 creator A5067847626 @default.
- W2165441808 date "2004-03-05" @default.
- W2165441808 modified "2023-10-18" @default.
- W2165441808 title "Increased Intimal Hyperplasia and Smooth Muscle Cell Proliferation in Transgenic Mice With Heparan Sulfate–Deficient Perlecan" @default.
- W2165441808 cites W1487106955 @default.
- W2165441808 cites W1512706674 @default.
- W2165441808 cites W1777057528 @default.
- W2165441808 cites W1855999912 @default.
- W2165441808 cites W1967362524 @default.
- W2165441808 cites W1968465587 @default.
- W2165441808 cites W1974262404 @default.
- W2165441808 cites W1976837011 @default.
- W2165441808 cites W1977798903 @default.
- W2165441808 cites W1995453479 @default.
- W2165441808 cites W1997120671 @default.
- W2165441808 cites W2000494074 @default.
- W2165441808 cites W2001991657 @default.
- W2165441808 cites W2015246053 @default.
- W2165441808 cites W2019301585 @default.
- W2165441808 cites W2021304013 @default.
- W2165441808 cites W2023105561 @default.
- W2165441808 cites W2034432297 @default.
- W2165441808 cites W2037076508 @default.
- W2165441808 cites W2039210162 @default.
- W2165441808 cites W2043484559 @default.
- W2165441808 cites W2047879815 @default.
- W2165441808 cites W2054255117 @default.
- W2165441808 cites W2057691724 @default.
- W2165441808 cites W2058354015 @default.
- W2165441808 cites W2081372118 @default.
- W2165441808 cites W2110188006 @default.
- W2165441808 cites W2119328943 @default.
- W2165441808 cites W2140969448 @default.
- W2165441808 cites W2142810135 @default.
- W2165441808 cites W2144328981 @default.
- W2165441808 cites W2148269129 @default.
- W2165441808 cites W2152264767 @default.
- W2165441808 cites W2410751280 @default.
- W2165441808 cites W4210571487 @default.
- W2165441808 cites W4242945710 @default.
- W2165441808 cites W4256475235 @default.
- W2165441808 doi "https://doi.org/10.1161/01.res.0000117772.86853.34" @default.
- W2165441808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14739157" @default.
- W2165441808 hasPublicationYear "2004" @default.
- W2165441808 type Work @default.
- W2165441808 sameAs 2165441808 @default.
- W2165441808 citedByCount "88" @default.
- W2165441808 countsByYear W21654418082012 @default.
- W2165441808 countsByYear W21654418082013 @default.
- W2165441808 countsByYear W21654418082014 @default.
- W2165441808 countsByYear W21654418082015 @default.
- W2165441808 countsByYear W21654418082017 @default.
- W2165441808 countsByYear W21654418082018 @default.
- W2165441808 countsByYear W21654418082019 @default.
- W2165441808 countsByYear W21654418082020 @default.
- W2165441808 countsByYear W21654418082022 @default.
- W2165441808 countsByYear W21654418082023 @default.
- W2165441808 crossrefType "journal-article" @default.
- W2165441808 hasAuthorship W2165441808A5000224317 @default.
- W2165441808 hasAuthorship W2165441808A5012025016 @default.
- W2165441808 hasAuthorship W2165441808A5019555799 @default.
- W2165441808 hasAuthorship W2165441808A5030429057 @default.
- W2165441808 hasAuthorship W2165441808A5064457105 @default.
- W2165441808 hasAuthorship W2165441808A5067847626 @default.
- W2165441808 hasConcept C123012128 @default.
- W2165441808 hasConcept C134018914 @default.
- W2165441808 hasConcept C1491633281 @default.
- W2165441808 hasConcept C170493617 @default.
- W2165441808 hasConcept C185592680 @default.
- W2165441808 hasConcept C189165786 @default.
- W2165441808 hasConcept C202751555 @default.
- W2165441808 hasConcept C22731427 @default.
- W2165441808 hasConcept C2776193487 @default.
- W2165441808 hasConcept C2776992346 @default.
- W2165441808 hasConcept C2777562237 @default.
- W2165441808 hasConcept C2778041096 @default.
- W2165441808 hasConcept C2779335624 @default.
- W2165441808 hasConcept C2779395532 @default.
- W2165441808 hasConcept C2779751240 @default.
- W2165441808 hasConcept C2992686903 @default.
- W2165441808 hasConcept C55493867 @default.
- W2165441808 hasConcept C62112901 @default.
- W2165441808 hasConcept C74373430 @default.
- W2165441808 hasConcept C86803240 @default.
- W2165441808 hasConcept C95444343 @default.
- W2165441808 hasConceptScore W2165441808C123012128 @default.
- W2165441808 hasConceptScore W2165441808C134018914 @default.
- W2165441808 hasConceptScore W2165441808C1491633281 @default.
- W2165441808 hasConceptScore W2165441808C170493617 @default.
- W2165441808 hasConceptScore W2165441808C185592680 @default.
- W2165441808 hasConceptScore W2165441808C189165786 @default.