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- W2165461566 abstract "The number of constituent amino acids in ribosomally synthetized and post-translationally modified peptide natural products (RiPPs) is restricted to the 20 canonical amino acids. Microorganisms with an engineered genetic code are capable of delivering the biological, chemical, or physical properties of many unnatural or synthetic noncanonical amino acids, ncAAs (in different combinations of their numbers and chemistry) precisely defined by the chemist at the bench. In this way, post-translational modifications (PTMs) which make RiPPs chemically extremely rich can be augmented by the co-translational insertion of ncAAs. This will dramatically expand the chemical and functional space of these molecules and enable the design of novel and unique sequence combinations with improved specificity, stability, membrane permeability and even better oral availability." @default.
- W2165461566 created "2016-06-24" @default.
- W2165461566 creator A5087966779 @default.
- W2165461566 date "2013-08-01" @default.
- W2165461566 modified "2023-10-07" @default.
- W2165461566 title "Expanded genetic code for the engineering of ribosomally synthetized and post-translationally modified peptide natural products (RiPPs)" @default.
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- W2165461566 doi "https://doi.org/10.1016/j.copbio.2013.02.026" @default.
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