FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165506592> ?p ?o ?g. }

• W2165506592 endingPage "77" @default.
• W2165506592 startingPage "67" @default.
• W2165506592 abstract "Liver insufficiency occurs when the liver cannot perform critical functions such as ammonia metabolism, gluconeogenesis, or production of coagulation factors The hypothesis of this study was that decreased function of existing hepatocytes may contribute to hepatic failure, and that the function of these cells might be increased pharmacologically. Lovastatin is a 3-hydroxy-3-methylglutaryl CoA reductase inhibitor that inhibits cholesterol biosynthesis and affects the activity of some signal transduction pathways and liver transcription factors. Changes in hepatic transcription factors during liver regeneration might result in decreased liver functions, and lovastatin might prevent these changesRats received 90% partial hepatectomy (90% PH), and either lovastatin or vehicle alone daily. Survival and liver functions were assessed.Lovastatin increased survival to 58% (vs. 6% in controls that received 90% PH without drug), decreased the peak ammonia level to 427 microM (vs. 846 microM in controls), increased the nadir of glucose to 88 mg/dl (vs. 57 mg/dl in controls), decreased the peak prothrombin time to 23 s (vs 29 s in controls), and decreased the peak activated partial thromboplastin time to 29 s (vs. 39 s in controls). The full survival and metabolic benefits were observed when lovastatin was started at 30 min after 90% PH, but lovastatin was less efficacious when started at later times.Lovastatin increases the function of existing hepatocytes and might be used to improve liver function after extensive hepatic resection." @default.
• W2165506592 created "2016-06-24" @default.
• W2165506592 creator A5002147474 @default.
• W2165506592 creator A5015792210 @default.
• W2165506592 creator A5018066193 @default.
• W2165506592 creator A5037541501 @default.
• W2165506592 creator A5047419053 @default.
• W2165506592 creator A5076317746 @default.
• W2165506592 date "2000-01-01" @default.
• W2165506592 modified "2023-10-16" @default.
• W2165506592 title "Lovastatin decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats" @default.
• W2165506592 cites W1517658624 @default.
• W2165506592 cites W1543207526 @default.
• W2165506592 cites W1702287731 @default.
• W2165506592 cites W1909027985 @default.
• W2165506592 cites W1923651867 @default.
• W2165506592 cites W1963668453 @default.
• W2165506592 cites W1969270752 @default.
• W2165506592 cites W1976100534 @default.
• W2165506592 cites W1981368571 @default.
• W2165506592 cites W1984672956 @default.
• W2165506592 cites W1995166802 @default.
• W2165506592 cites W2007186592 @default.
• W2165506592 cites W2019575221 @default.
• W2165506592 cites W2032890774 @default.
• W2165506592 cites W2033437499 @default.
• W2165506592 cites W2044132381 @default.
• W2165506592 cites W2047347790 @default.
• W2165506592 cites W2049056191 @default.
• W2165506592 cites W2056385716 @default.
• W2165506592 cites W2059513263 @default.
• W2165506592 cites W2073613118 @default.
• W2165506592 cites W2075517109 @default.
• W2165506592 cites W2117774293 @default.
• W2165506592 cites W2120746654 @default.
• W2165506592 cites W2131498173 @default.
• W2165506592 cites W2132097023 @default.
• W2165506592 cites W2324029042 @default.
• W2165506592 cites W2325329269 @default.
• W2165506592 cites W2418221041 @default.
• W2165506592 cites W2418699037 @default.
• W2165506592 cites W4211173486 @default.
• W2165506592 cites W4298249848 @default.
• W2165506592 cites W4379137121 @default.
• W2165506592 doi "https://doi.org/10.1016/s0168-8278(00)80191-9" @default.
• W2165506592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10673069" @default.
• W2165506592 hasPublicationYear "2000" @default.
• W2165506592 type Work @default.
• W2165506592 sameAs 2165506592 @default.
• W2165506592 citedByCount "21" @default.
• W2165506592 countsByYear W21655065922012 @default.
• W2165506592 countsByYear W21655065922014 @default.
• W2165506592 countsByYear W21655065922015 @default.
• W2165506592 countsByYear W21655065922018 @default.
• W2165506592 countsByYear W21655065922019 @default.
• W2165506592 crossrefType "journal-article" @default.
• W2165506592 hasAuthorship W2165506592A5002147474 @default.
• W2165506592 hasAuthorship W2165506592A5015792210 @default.
• W2165506592 hasAuthorship W2165506592A5018066193 @default.
• W2165506592 hasAuthorship W2165506592A5037541501 @default.
• W2165506592 hasAuthorship W2165506592A5047419053 @default.
• W2165506592 hasAuthorship W2165506592A5076317746 @default.
• W2165506592 hasConcept C126322002 @default.
• W2165506592 hasConcept C134018914 @default.
• W2165506592 hasConcept C141071460 @default.
• W2165506592 hasConcept C159110652 @default.
• W2165506592 hasConcept C185592680 @default.
• W2165506592 hasConcept C202751555 @default.
• W2165506592 hasConcept C20904676 @default.
• W2165506592 hasConcept C2776200302 @default.
• W2165506592 hasConcept C2776909242 @default.
• W2165506592 hasConcept C2778163477 @default.
• W2165506592 hasConcept C2779609443 @default.
• W2165506592 hasConcept C2780434524 @default.
• W2165506592 hasConcept C2780940807 @default.
• W2165506592 hasConcept C2911091166 @default.
• W2165506592 hasConcept C2911118192 @default.
• W2165506592 hasConcept C2992208098 @default.
• W2165506592 hasConcept C55493867 @default.
• W2165506592 hasConcept C62231903 @default.
• W2165506592 hasConcept C71924100 @default.
• W2165506592 hasConcept C86803240 @default.
• W2165506592 hasConceptScore W2165506592C126322002 @default.
• W2165506592 hasConceptScore W2165506592C134018914 @default.
• W2165506592 hasConceptScore W2165506592C141071460 @default.
• W2165506592 hasConceptScore W2165506592C159110652 @default.
• W2165506592 hasConceptScore W2165506592C185592680 @default.
• W2165506592 hasConceptScore W2165506592C202751555 @default.
• W2165506592 hasConceptScore W2165506592C20904676 @default.
• W2165506592 hasConceptScore W2165506592C2776200302 @default.
• W2165506592 hasConceptScore W2165506592C2776909242 @default.
• W2165506592 hasConceptScore W2165506592C2778163477 @default.
• W2165506592 hasConceptScore W2165506592C2779609443 @default.
• W2165506592 hasConceptScore W2165506592C2780434524 @default.
• W2165506592 hasConceptScore W2165506592C2780940807 @default.
• W2165506592 hasConceptScore W2165506592C2911091166 @default.
• W2165506592 hasConceptScore W2165506592C2911118192 @default.
• W2165506592 hasConceptScore W2165506592C2992208098 @default.

• next