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• W2165507029 startingPage "169" @default.
• W2165507029 abstract "Proton pump inhibitors are often prescribed for patients on clopidogrel to prevent gastrointestinal bleeding complications. Recent data suggest higher rates of adverse cardiovascular events in patients on proton pump inhibitors and clopidogrel, in comparison to patients on clopidogrel only. Both drugs are metabolized by similar pathways of the cytochrome P450 system, so proton pump inhibitors may inhibit the metabolism of clopidogrel to its active metabolite. This article reviews the pharmacodynamic and clinical evidence for this phenomenon." @default.
• W2165507029 created "2016-06-24" @default.
• W2165507029 creator A5002279235 @default.
• W2165507029 creator A5070552818 @default.
• W2165507029 date "2010-03-25" @default.
• W2165507029 modified "2023-10-09" @default.
• W2165507029 title "Proton Pump Inhibitors and Clopidogrel" @default.
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• W2165507029 doi "https://doi.org/10.1111/j.1755-5922.2010.00143.x" @default.
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