FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165508810> ?p ?o ?g. }

• W2165508810 endingPage "279" @default.
• W2165508810 startingPage "260" @default.
• W2165508810 abstract "Meiosis is a highly conserved process, which is stringently regulated in all organisms, from fungi through to humans. Two major events define meiosis in eukaryotes. The first is the pairing, or synapsis, of homologous chromosomes and the second is the exchange of genetic information in a process called meiotic recombination. Synapsis is mediated by the meiosis-specific synaptonemal complex structure in combination with the cohesins that tether sister chromatids together along chromosome arms through prophase I. Previously, we identified FKBP6 as a novel component of the mammalian synaptonemal complex. Further studies demonstrated an interaction between FKBP6 and the NIMA-related kinase-1, NEK1. To further investigate the role of NEK1 in mammalian meiosis, we have examined gametogenesis in the spontaneous mutant, Nek1kat2J. Homozygous mutant animals show decreased testis size, defects in testis morphology, and in cohesin removal at late prophase I of meiosis, causing complete male infertility. Cohesin protein SMC3 remains localized to the meiotic chromosome cores at diplonema in the Nek1 mutant, and also in the related Fkbp6 mutant, while in wild type cells SMC3 is removed from the cores at the end of prophase I and becomes more diffuse throughout the DAPI stained region of the nucleus. These data implicate NEK1 as a possible kinase involved in cohesin redistribution in murine spermatocytes." @default.
• W2165508810 created "2016-06-24" @default.
• W2165508810 creator A5019780403 @default.
• W2165508810 creator A5048065812 @default.
• W2165508810 creator A5049376869 @default.
• W2165508810 creator A5056470643 @default.
• W2165508810 creator A5057482538 @default.
• W2165508810 creator A5057978701 @default.
• W2165508810 date "2011-03-07" @default.
• W2165508810 modified "2023-09-27" @default.
• W2165508810 title "NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis" @default.
• W2165508810 cites W1529934215 @default.
• W2165508810 cites W1530897177 @default.
• W2165508810 cites W1532143905 @default.
• W2165508810 cites W1956748106 @default.
• W2165508810 cites W1966478901 @default.
• W2165508810 cites W1975530443 @default.
• W2165508810 cites W1976588897 @default.
• W2165508810 cites W1979291624 @default.
• W2165508810 cites W1981717620 @default.
• W2165508810 cites W1983844625 @default.
• W2165508810 cites W1997226150 @default.
• W2165508810 cites W2000152046 @default.
• W2165508810 cites W2004007221 @default.
• W2165508810 cites W2010442490 @default.
• W2165508810 cites W2012242395 @default.
• W2165508810 cites W2023025627 @default.
• W2165508810 cites W2023411715 @default.
• W2165508810 cites W2023902905 @default.
• W2165508810 cites W2033845019 @default.
• W2165508810 cites W2048710914 @default.
• W2165508810 cites W2065359367 @default.
• W2165508810 cites W2065922392 @default.
• W2165508810 cites W2067338267 @default.
• W2165508810 cites W2073540637 @default.
• W2165508810 cites W2074350748 @default.
• W2165508810 cites W2080667961 @default.
• W2165508810 cites W2081213729 @default.
• W2165508810 cites W2085064256 @default.
• W2165508810 cites W2089791517 @default.
• W2165508810 cites W2093342789 @default.
• W2165508810 cites W2094892383 @default.
• W2165508810 cites W2097846668 @default.
• W2165508810 cites W2099304384 @default.
• W2165508810 cites W2103581095 @default.
• W2165508810 cites W2111893619 @default.
• W2165508810 cites W2118490056 @default.
• W2165508810 cites W2118746619 @default.
• W2165508810 cites W2118972444 @default.
• W2165508810 cites W2121312894 @default.
• W2165508810 cites W2125077812 @default.
• W2165508810 cites W2139409703 @default.
• W2165508810 cites W2140074366 @default.
• W2165508810 cites W2140164632 @default.
• W2165508810 cites W2153234222 @default.
• W2165508810 cites W2156632388 @default.
• W2165508810 cites W2171960324 @default.
• W2165508810 cites W224565734 @default.
• W2165508810 cites W316415966 @default.
• W2165508810 doi "https://doi.org/10.3390/genes2010260" @default.
• W2165508810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3175124" @default.
• W2165508810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21931878" @default.
• W2165508810 hasPublicationYear "2011" @default.
• W2165508810 type Work @default.
• W2165508810 sameAs 2165508810 @default.
• W2165508810 citedByCount "13" @default.
• W2165508810 countsByYear W21655088102014 @default.
• W2165508810 countsByYear W21655088102015 @default.
• W2165508810 countsByYear W21655088102016 @default.
• W2165508810 countsByYear W21655088102017 @default.
• W2165508810 countsByYear W21655088102020 @default.
• W2165508810 countsByYear W21655088102021 @default.
• W2165508810 countsByYear W21655088102022 @default.
• W2165508810 countsByYear W21655088102023 @default.
• W2165508810 crossrefType "journal-article" @default.
• W2165508810 hasAuthorship W2165508810A5019780403 @default.
• W2165508810 hasAuthorship W2165508810A5048065812 @default.
• W2165508810 hasAuthorship W2165508810A5049376869 @default.
• W2165508810 hasAuthorship W2165508810A5056470643 @default.
• W2165508810 hasAuthorship W2165508810A5057482538 @default.
• W2165508810 hasAuthorship W2165508810A5057978701 @default.
• W2165508810 hasBestOaLocation W21655088101 @default.
• W2165508810 hasConcept C101434241 @default.
• W2165508810 hasConcept C104317684 @default.
• W2165508810 hasConcept C115220002 @default.
• W2165508810 hasConcept C115821613 @default.
• W2165508810 hasConcept C148196450 @default.
• W2165508810 hasConcept C156695909 @default.
• W2165508810 hasConcept C201437064 @default.
• W2165508810 hasConcept C2778354886 @default.
• W2165508810 hasConcept C2910992960 @default.
• W2165508810 hasConcept C30481170 @default.
• W2165508810 hasConcept C45413362 @default.
• W2165508810 hasConcept C54059333 @default.
• W2165508810 hasConcept C54355233 @default.
• W2165508810 hasConcept C64894306 @default.
• W2165508810 hasConcept C73397532 @default.
• W2165508810 hasConcept C8502773 @default.

• next