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• W2165528840 abstract "Abstract Infusion of blood cells from a donor can induce humoral tolerance in a recipient and increase the probability of successful organ transplant, a clinical method defined as donor-specific transfusion (DST). Despite the clinical success of DST, the immunological mechanisms by which blood cells displaying a foreign Ag induce tolerance remain poorly understood. Based on recent findings showing that the B cell siglecs, CD22 and Siglec-G, can promote tolerance to Ags presented on the same surface as their ligands, we speculated that the B cell siglecs are key players in tolerance induced by DST. Using a variety of chemical and genetic approaches, we show that the B cell siglecs mediate tolerance to cell surface Ags by initiating an inhibitory signal that culminates in elimination of the Ag-reactive B cell. CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge. We speculate that this tolerogenic mechanism is a contributing factor in DST and a mechanism of peripheral B cell tolerance to cell surface autoantigens." @default.
• W2165528840 created "2016-06-24" @default.
• W2165528840 creator A5008486770 @default.
• W2165528840 creator A5039824850 @default.
• W2165528840 date "2014-11-01" @default.
• W2165528840 modified "2023-10-14" @default.
• W2165528840 title "Siglecs Induce Tolerance to Cell Surface Antigens by BIM-Dependent Deletion of the Antigen-Reactive B Cells" @default.
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• W2165528840 doi "https://doi.org/10.4049/jimmunol.1401723" @default.
• W2165528840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4201975" @default.
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• W2165528840 hasPublicationYear "2014" @default.
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