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• W2165536982 endingPage "C790" @default.
• W2165536982 startingPage "C779" @default.
• W2165536982 abstract "Phenotypic modulation of vascular myocytes is important for vascular development and adaptation. A characteristic feature of this process is alteration in intracellular Ca 2+ handling, which is not completely understood. We studied mechanisms involved in functional changes of inositol 1,4,5-trisphosphate (IP 3 )- and ryanodine (Ry)-sensitive Ca 2+ stores, store-operated Ca 2+ entry (SOCE), and receptor-operated Ca 2+ entry (ROCE) associated with arterial myocyte modulation from a contractile to a proliferative phenotype in culture. Proliferating, cultured myocytes from rat mesenteric artery have elevated resting cytosolic Ca 2+ levels and increased IP 3 -sensitive Ca 2+ store content. ATP- and cyclopiazonic acid [CPA; a sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA) inhibitor]-induced Ca 2+ transients in Ca 2+ -free medium are significantly larger in proliferating arterial smooth muscle cells (ASMCs) than in freshly dissociated myocytes, whereas caffeine (Caf)-induced Ca 2+ release is much smaller. Moreover, the Caf/Ry-sensitive store gradually loses sensitivity to Caf activation during cell culture. These changes can be explained by increased expression of all three IP 3 receptors and a switch from Ry receptor type II to type III expression during proliferation. SOCE, activated by depletion of the IP 3 /CPA-sensitive store, is greatly increased in proliferating ASMCs. Augmented SOCE and ROCE (activated by the diacylglycerol analog 1-oleoyl-2-acetyl- sn-glycerol) in proliferating myocytes can be attributed to upregulated expression of, respectively, transient receptor potential proteins TRPC1/4/5 and TRPC3/6. Moreover, stromal interacting molecule 1 (STIM1) and Orai proteins are upregulated in proliferating cells. Increased expression of IP 3 receptors, SERCA2b, TRPCs, Orai(s), and STIM1 in proliferating ASMCs suggests that these proteins play a critical role in an altered Ca 2+ handling that occurs during vascular growth and remodeling." @default.
• W2165536982 created "2016-06-24" @default.
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• W2165536982 creator A5032778961 @default.
• W2165536982 creator A5048000499 @default.
• W2165536982 creator A5048681537 @default.
• W2165536982 date "2008-09-01" @default.
• W2165536982 modified "2023-10-15" @default.
• W2165536982 title "Ca²⁺handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture" @default.
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• W2165536982 doi "https://doi.org/10.1152/ajpcell.00173.2008" @default.
• W2165536982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2544451" @default.
• W2165536982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18596214" @default.
• W2165536982 hasPublicationYear "2008" @default.
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