Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165566229> ?p ?o ?g. }
- W2165566229 endingPage "2708" @default.
- W2165566229 startingPage "2698" @default.
- W2165566229 abstract "Calcineurin is a Ca 2+ /calmodulin-regulated protein phosphatase required for Saccharomyces cerevisiae to respond to a variety of environmental stresses. Calcineurin promotes cell survival during stress by dephosphorylating and activating the Zn-finger transcription factor Crz1p/Tcn1p. Using a high-throughput assay, we screened 119 yeast kinases for their ability to phosphorylate Crz1p in vitro and identified the casein kinase I homolog Hrr25p. Here we show that Hrr25p negatively regulates Crz1p activity and nuclear localization in vivo. Hrr25p binds to and phosphorylates Crz1p in vitro and in vivo. Overexpression of Hrr25p decreases Crz1p-dependent transcription and antagonizes its Ca 2+ -induced nuclear accumulation. In the absence of Hrr25p, activation of Crz1p by Ca 2+ /calcineurin is potentiated. These findings represent the first identification of a negative regulator for Crz1p, and establish a novel physiological role for Hrr25p in antagonizing calcineurin signaling." @default.
- W2165566229 created "2016-06-24" @default.
- W2165566229 creator A5024120181 @default.
- W2165566229 creator A5041893103 @default.
- W2165566229 creator A5059446355 @default.
- W2165566229 creator A5087724111 @default.
- W2165566229 date "2003-11-01" @default.
- W2165566229 modified "2023-09-25" @default.
- W2165566229 title "Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I" @default.
- W2165566229 cites W1493538154 @default.
- W2165566229 cites W1504478980 @default.
- W2165566229 cites W1556726910 @default.
- W2165566229 cites W1569503463 @default.
- W2165566229 cites W1587918801 @default.
- W2165566229 cites W1589290041 @default.
- W2165566229 cites W1850569493 @default.
- W2165566229 cites W1881030466 @default.
- W2165566229 cites W1888736125 @default.
- W2165566229 cites W1979246102 @default.
- W2165566229 cites W1985339191 @default.
- W2165566229 cites W1985533490 @default.
- W2165566229 cites W1986603094 @default.
- W2165566229 cites W1989315368 @default.
- W2165566229 cites W1991532862 @default.
- W2165566229 cites W1992992274 @default.
- W2165566229 cites W2003905487 @default.
- W2165566229 cites W2022876115 @default.
- W2165566229 cites W2037036397 @default.
- W2165566229 cites W2057149245 @default.
- W2165566229 cites W2062469526 @default.
- W2165566229 cites W2068393186 @default.
- W2165566229 cites W2071056869 @default.
- W2165566229 cites W2073464836 @default.
- W2165566229 cites W2074607472 @default.
- W2165566229 cites W2080565111 @default.
- W2165566229 cites W2093714495 @default.
- W2165566229 cites W2097801967 @default.
- W2165566229 cites W2101400842 @default.
- W2165566229 cites W2108367015 @default.
- W2165566229 cites W2110510554 @default.
- W2165566229 cites W2114978834 @default.
- W2165566229 cites W2119811365 @default.
- W2165566229 cites W2123738381 @default.
- W2165566229 cites W2126241360 @default.
- W2165566229 cites W2132723128 @default.
- W2165566229 cites W2137130856 @default.
- W2165566229 cites W2140884549 @default.
- W2165566229 cites W2142160977 @default.
- W2165566229 cites W2142437744 @default.
- W2165566229 cites W2143816403 @default.
- W2165566229 cites W2148745798 @default.
- W2165566229 cites W2154035538 @default.
- W2165566229 cites W2156433522 @default.
- W2165566229 cites W2157058776 @default.
- W2165566229 cites W2160091872 @default.
- W2165566229 cites W2169333620 @default.
- W2165566229 cites W2169971858 @default.
- W2165566229 cites W4231153829 @default.
- W2165566229 cites W4239741881 @default.
- W2165566229 cites W4240065971 @default.
- W2165566229 doi "https://doi.org/10.1101/gad.1140603" @default.
- W2165566229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/280619" @default.
- W2165566229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14597664" @default.
- W2165566229 hasPublicationYear "2003" @default.
- W2165566229 type Work @default.
- W2165566229 sameAs 2165566229 @default.
- W2165566229 citedByCount "75" @default.
- W2165566229 countsByYear W21655662292012 @default.
- W2165566229 countsByYear W21655662292013 @default.
- W2165566229 countsByYear W21655662292014 @default.
- W2165566229 countsByYear W21655662292015 @default.
- W2165566229 countsByYear W21655662292016 @default.
- W2165566229 countsByYear W21655662292017 @default.
- W2165566229 countsByYear W21655662292018 @default.
- W2165566229 countsByYear W21655662292019 @default.
- W2165566229 countsByYear W21655662292020 @default.
- W2165566229 countsByYear W21655662292021 @default.
- W2165566229 countsByYear W21655662292022 @default.
- W2165566229 countsByYear W21655662292023 @default.
- W2165566229 crossrefType "journal-article" @default.
- W2165566229 hasAuthorship W2165566229A5024120181 @default.
- W2165566229 hasAuthorship W2165566229A5041893103 @default.
- W2165566229 hasAuthorship W2165566229A5059446355 @default.
- W2165566229 hasAuthorship W2165566229A5087724111 @default.
- W2165566229 hasBestOaLocation W21655662291 @default.
- W2165566229 hasConcept C104317684 @default.
- W2165566229 hasConcept C11960822 @default.
- W2165566229 hasConcept C128057223 @default.
- W2165566229 hasConcept C141071460 @default.
- W2165566229 hasConcept C143910341 @default.
- W2165566229 hasConcept C160110348 @default.
- W2165566229 hasConcept C178666793 @default.
- W2165566229 hasConcept C181199279 @default.
- W2165566229 hasConcept C181912034 @default.
- W2165566229 hasConcept C184235292 @default.
- W2165566229 hasConcept C2777576037 @default.
- W2165566229 hasConcept C2779222958 @default.
- W2165566229 hasConcept C2911091166 @default.