FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165577181> ?p ?o ?g. }

• W2165577181 endingPage "1723" @default.
• W2165577181 startingPage "1712" @default.
• W2165577181 abstract "The success of using glycolytic inhibitors for cancer treatment depends on studying the individual role of frequently deregulated glycolytic genes in cancer. This report aims to study the prognostic implication, and determine the cellular role and action mechanism of glycolytic ENO1 overexpression in head and neck cancer. The relationship of ENO1 mRNA expression in 44-pair clinical specimens with patient clinicopathologic characteristics was analysed by semi-quantitative RT-PCR, Kaplan–Meier survival curve and Cox model analyses. Following ectopic ENO1 expression or knockdown, we studied the proliferative, migratory, invasive, colony-forming and tumourigenic abilities of ENO1-genetically altered cells. DNA microarray analysis was used to identify downstream targets responsible for the ENO1 action in the cells. The expression of ENO1 mRNA was increased in 68% of tumour (T) specimens when compared to their normal (N) counterparts, and positively associated with clinical progression (p < 0.05). High ENO1 expression (T/N ⩾ 2) was frequently observed in the patients with large primary tumours, late clinical stages or advanced neck metastasis. Moreover, high ENO1 patients had significantly poorer clinical outcomes than low expressers (T/N < 2). Ectopic ENO1 expression stimulated cell transformation, invasion and tongue tumour formation. ENO1 knockdown abrogated the stimulation. Suppression of ENO1-induced proinflammatory CCL20 chemokine expression significantly attenuated its stimulatory effects on cell transformation and invasion. A concordant expression of ENO1 and CCL20 was validated both in ENO1-expresing cells and in clinical specimens. Together, we demonstrate a prognostic role of ENO1 overexpression in head and neck cancer and ENO1-mediated promotion of cell transformation and invasion partly via induced CCL20 expression." @default.
• W2165577181 created "2016-06-24" @default.
• W2165577181 creator A5015973540 @default.
• W2165577181 creator A5017286773 @default.
• W2165577181 creator A5045058795 @default.
• W2165577181 creator A5045822627 @default.
• W2165577181 creator A5047004176 @default.
• W2165577181 creator A5062374856 @default.
• W2165577181 creator A5066817532 @default.
• W2165577181 creator A5070102648 @default.
• W2165577181 creator A5075579975 @default.
• W2165577181 creator A5083060037 @default.
• W2165577181 date "2010-06-01" @default.
• W2165577181 modified "2023-10-11" @default.
• W2165577181 title "ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction" @default.
• W2165577181 cites W1545790360 @default.
• W2165577181 cites W1966900644 @default.
• W2165577181 cites W1969156632 @default.
• W2165577181 cites W1970252458 @default.
• W2165577181 cites W1976632546 @default.
• W2165577181 cites W1998478665 @default.
• W2165577181 cites W2010394923 @default.
• W2165577181 cites W2023128342 @default.
• W2165577181 cites W2024207843 @default.
• W2165577181 cites W2024400556 @default.
• W2165577181 cites W2042314261 @default.
• W2165577181 cites W2064052598 @default.
• W2165577181 cites W2065791048 @default.
• W2165577181 cites W2070338369 @default.
• W2165577181 cites W2072939418 @default.
• W2165577181 cites W2076744242 @default.
• W2165577181 cites W2085153747 @default.
• W2165577181 cites W2085416202 @default.
• W2165577181 cites W2102666037 @default.
• W2165577181 cites W2103765110 @default.
• W2165577181 cites W2111159494 @default.
• W2165577181 cites W2115287848 @default.
• W2165577181 cites W2137823306 @default.
• W2165577181 cites W2139365091 @default.
• W2165577181 cites W2147206974 @default.
• W2165577181 cites W2164300744 @default.
• W2165577181 cites W2166836648 @default.
• W2165577181 cites W2167391679 @default.
• W2165577181 cites W271570111 @default.
• W2165577181 cites W4205129348 @default.
• W2165577181 doi "https://doi.org/10.1016/j.ejca.2010.03.018" @default.
• W2165577181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20435467" @default.
• W2165577181 hasPublicationYear "2010" @default.
• W2165577181 type Work @default.
• W2165577181 sameAs 2165577181 @default.
• W2165577181 citedByCount "92" @default.
• W2165577181 countsByYear W21655771812012 @default.
• W2165577181 countsByYear W21655771812013 @default.
• W2165577181 countsByYear W21655771812014 @default.
• W2165577181 countsByYear W21655771812015 @default.
• W2165577181 countsByYear W21655771812016 @default.
• W2165577181 countsByYear W21655771812017 @default.
• W2165577181 countsByYear W21655771812018 @default.
• W2165577181 countsByYear W21655771812019 @default.
• W2165577181 countsByYear W21655771812020 @default.
• W2165577181 countsByYear W21655771812021 @default.
• W2165577181 countsByYear W21655771812022 @default.
• W2165577181 countsByYear W21655771812023 @default.
• W2165577181 crossrefType "journal-article" @default.
• W2165577181 hasAuthorship W2165577181A5015973540 @default.
• W2165577181 hasAuthorship W2165577181A5017286773 @default.
• W2165577181 hasAuthorship W2165577181A5045058795 @default.
• W2165577181 hasAuthorship W2165577181A5045822627 @default.
• W2165577181 hasAuthorship W2165577181A5047004176 @default.
• W2165577181 hasAuthorship W2165577181A5062374856 @default.
• W2165577181 hasAuthorship W2165577181A5066817532 @default.
• W2165577181 hasAuthorship W2165577181A5070102648 @default.
• W2165577181 hasAuthorship W2165577181A5075579975 @default.
• W2165577181 hasAuthorship W2165577181A5083060037 @default.
• W2165577181 hasConcept C121608353 @default.
• W2165577181 hasConcept C142724271 @default.
• W2165577181 hasConcept C173396325 @default.
• W2165577181 hasConcept C2779013556 @default.
• W2165577181 hasConcept C31033888 @default.
• W2165577181 hasConcept C502942594 @default.
• W2165577181 hasConcept C54355233 @default.
• W2165577181 hasConcept C555283112 @default.
• W2165577181 hasConcept C71924100 @default.
• W2165577181 hasConcept C81885089 @default.
• W2165577181 hasConcept C86803240 @default.
• W2165577181 hasConcept C97037327 @default.
• W2165577181 hasConceptScore W2165577181C121608353 @default.
• W2165577181 hasConceptScore W2165577181C142724271 @default.
• W2165577181 hasConceptScore W2165577181C173396325 @default.
• W2165577181 hasConceptScore W2165577181C2779013556 @default.
• W2165577181 hasConceptScore W2165577181C31033888 @default.
• W2165577181 hasConceptScore W2165577181C502942594 @default.
• W2165577181 hasConceptScore W2165577181C54355233 @default.
• W2165577181 hasConceptScore W2165577181C555283112 @default.
• W2165577181 hasConceptScore W2165577181C71924100 @default.
• W2165577181 hasConceptScore W2165577181C81885089 @default.
• W2165577181 hasConceptScore W2165577181C86803240 @default.
• W2165577181 hasConceptScore W2165577181C97037327 @default.

• next