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• W2165589920 abstract "Abstract To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e. , (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [ 3 H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli . The amount of (Q-)tRNA in high-grade lymphomas (mean ± SD, 38.64 ± 22.81) is substantially greater than that observed in germinal center cell lymphomas (7.15 ± 4.0) and chronic lymphocytic leukemia at a favorable prognostic stage (4.63 ± 1.84) and in non-neoplastic lymphoid tissues (4.52 ± 3.17). In chronic lymphocytic leukemia lymphocytes it increases from stage A to C of the Binet classification: 4.63 ± 1.84 (A); 9.25 ± 1.45 (B); and 25.87 ± 8.9 (C). Increasing values were also observed in representatives of late B-cell differentiation (hairy cell leukemia, 14.8 ± 0.4; immunocytoma and plasmacytoma, 21.58 ± 4.62). On electrophoresis, a characteristic pattern of undermodified tRNA species was found in some neoplastic cells. Determination of free queuine in neoplastic and non-neoplastic human lymphatic specimens suggests that undermodification of tRNA does not arise from substrate limitation. The results indicate that a decreased queuosine content of tRNA is not a general feature of neoplasms, but it may be important for disease activity and perhaps also for the state of maturation in human lymphomas and leukemias." @default.
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• W2165589920 date "1985-09-01" @default.
• W2165589920 modified "2023-09-26" @default.
• W2165589920 title "Relationship of queuine-lacking transfer RNA to the grade of malignancy in human leukemias and lymphomas." @default.
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