FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165617840> ?p ?o ?g. }

• W2165617840 endingPage "2873" @default.
• W2165617840 startingPage "2869" @default.
• W2165617840 abstract "Human papillomavirus (HPV) integration within the E2 gene has been proposed as a critical event in cervical carcinogenesis. This study concerned whether HPV16 status and E2 gene intactness are predictive of radiation response in patients with cervical cancer.Biopsies of 44 patients with cervical cancer were collected before or after radiotherapy. The presence of HPV16 was assessed by polymerase chain reaction (PCR) using specific primers for the L1 region. E2 disruption was detected by amplifying the entire E2 gene.HPV16 DNA was found in 54.5% of the clinical samples. Overall, 62.5% of the HPV16 positive tumors had integrated viral genome and 37.5% had episomal genome. There was a tendency of increase of HPV16 E2 negative tumors compared with HPV16 L1 ones in advanced stages (75% versus 20% in stage III respectively). Detection of E2 gene appeared influenced by the radiotherapy treatment, as the percentage of samples containing an intact HPV16 E2 was more frequent in pretreated patients compared to radiotherapy treated patients (66.6% versus 20%). The radiation therapy caused an eight-fold [OR= 8; CI=1.22-52.25; p=0.03] increase in the risk of HPV16 genome disruption. The integration status is influenced by the irradiation modalities, interestingly E2 disruption being found widely after radiotherapy treatment (75%) with a total fractioned dose of 50 Gy.This study reveals that the status of the viral DNA may be used as a marker to optimize the radiation treatment." @default.
• W2165617840 created "2016-06-24" @default.
• W2165617840 creator A5004240245 @default.
• W2165617840 creator A5015934141 @default.
• W2165617840 creator A5057581599 @default.
• W2165617840 creator A5061720379 @default.
• W2165617840 date "2014-03-30" @default.
• W2165617840 modified "2023-09-24" @default.
• W2165617840 title "Situation of HPV16 E2 Gene Status During Radiotherapy Treatment of Cervical Carcinoma" @default.
• W2165617840 cites W1973803676 @default.
• W2165617840 cites W1978429201 @default.
• W2165617840 cites W1992809837 @default.
• W2165617840 cites W1999043181 @default.
• W2165617840 cites W2020830322 @default.
• W2165617840 cites W2027448950 @default.
• W2165617840 cites W2037971006 @default.
• W2165617840 cites W2041959453 @default.
• W2165617840 cites W2058802528 @default.
• W2165617840 cites W2061275748 @default.
• W2165617840 cites W2077871003 @default.
• W2165617840 cites W2085584033 @default.
• W2165617840 cites W2088342207 @default.
• W2165617840 cites W2091789595 @default.
• W2165617840 cites W2109117395 @default.
• W2165617840 cites W2117869477 @default.
• W2165617840 cites W2117931146 @default.
• W2165617840 cites W2118200630 @default.
• W2165617840 cites W2136728738 @default.
• W2165617840 cites W2149166037 @default.
• W2165617840 cites W2149633402 @default.
• W2165617840 cites W2156657350 @default.
• W2165617840 cites W2168186645 @default.
• W2165617840 cites W2324806349 @default.
• W2165617840 cites W2886259079 @default.
• W2165617840 cites W45459227 @default.
• W2165617840 doi "https://doi.org/10.7314/apjcp.2014.15.6.2869" @default.
• W2165617840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24761916" @default.
• W2165617840 hasPublicationYear "2014" @default.
• W2165617840 type Work @default.
• W2165617840 sameAs 2165617840 @default.
• W2165617840 citedByCount "8" @default.
• W2165617840 countsByYear W21656178402014 @default.
• W2165617840 countsByYear W21656178402015 @default.
• W2165617840 countsByYear W21656178402016 @default.
• W2165617840 countsByYear W21656178402017 @default.
• W2165617840 countsByYear W21656178402018 @default.
• W2165617840 countsByYear W21656178402019 @default.
• W2165617840 countsByYear W21656178402023 @default.
• W2165617840 crossrefType "journal-article" @default.
• W2165617840 hasAuthorship W2165617840A5004240245 @default.
• W2165617840 hasAuthorship W2165617840A5015934141 @default.
• W2165617840 hasAuthorship W2165617840A5057581599 @default.
• W2165617840 hasAuthorship W2165617840A5061720379 @default.
• W2165617840 hasBestOaLocation W21656178401 @default.
• W2165617840 hasConcept C104317684 @default.
• W2165617840 hasConcept C121608353 @default.
• W2165617840 hasConcept C126322002 @default.
• W2165617840 hasConcept C141231307 @default.
• W2165617840 hasConcept C143998085 @default.
• W2165617840 hasConcept C2778220009 @default.
• W2165617840 hasConcept C2993195994 @default.
• W2165617840 hasConcept C49105822 @default.
• W2165617840 hasConcept C502942594 @default.
• W2165617840 hasConcept C509974204 @default.
• W2165617840 hasConcept C54355233 @default.
• W2165617840 hasConcept C555283112 @default.
• W2165617840 hasConcept C71924100 @default.
• W2165617840 hasConcept C7602840 @default.
• W2165617840 hasConcept C86803240 @default.
• W2165617840 hasConceptScore W2165617840C104317684 @default.
• W2165617840 hasConceptScore W2165617840C121608353 @default.
• W2165617840 hasConceptScore W2165617840C126322002 @default.
• W2165617840 hasConceptScore W2165617840C141231307 @default.
• W2165617840 hasConceptScore W2165617840C143998085 @default.
• W2165617840 hasConceptScore W2165617840C2778220009 @default.
• W2165617840 hasConceptScore W2165617840C2993195994 @default.
• W2165617840 hasConceptScore W2165617840C49105822 @default.
• W2165617840 hasConceptScore W2165617840C502942594 @default.
• W2165617840 hasConceptScore W2165617840C509974204 @default.
• W2165617840 hasConceptScore W2165617840C54355233 @default.
• W2165617840 hasConceptScore W2165617840C555283112 @default.
• W2165617840 hasConceptScore W2165617840C71924100 @default.
• W2165617840 hasConceptScore W2165617840C7602840 @default.
• W2165617840 hasConceptScore W2165617840C86803240 @default.
• W2165617840 hasIssue "6" @default.
• W2165617840 hasLocation W21656178401 @default.
• W2165617840 hasLocation W21656178402 @default.
• W2165617840 hasOpenAccess W2165617840 @default.
• W2165617840 hasPrimaryLocation W21656178401 @default.
• W2165617840 hasRelatedWork W2146804513 @default.
• W2165617840 hasRelatedWork W2381621670 @default.
• W2165617840 hasRelatedWork W2384708512 @default.
• W2165617840 hasRelatedWork W2513668488 @default.
• W2165617840 hasRelatedWork W2596108460 @default.
• W2165617840 hasRelatedWork W2800842377 @default.
• W2165617840 hasRelatedWork W2952970864 @default.
• W2165617840 hasRelatedWork W300962949 @default.
• W2165617840 hasRelatedWork W4212827698 @default.

• next