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- W2165626042 abstract "Biosynthesis of iron–sulphur (Fe-S) proteins is catalysed by multi-protein systems, ISC and SUF. However, ‘non-ISC, non-SUF’ Fe-S biosynthesis factors have been described, both in prokaryotes and eukaryotes. Here we report in vitro and in vivo investigations of such a ‘non-ISC, non SUF’ component, the Nfu proteins. Phylogenomic analysis allowed us to define four subfamilies. Escherichia coli NfuA is within subfamily II. Most members of this subfamily have a Nfu domain fused to a ‘degenerate’ A-type carrier domain (ATC*) lacking Fe-S cluster co-ordinating Cys ligands. The Nfu domain binds a [4Fe-4S] cluster while the ATC* domain interacts with NuoG (a complex I subunit) and aconitase B (AcnB). In vitro, holo-NfuA promotes maturation of AcnB. In vivo, NfuA is necessary for full activity of complex I under aerobic growth conditions, and of AcnB in the presence of superoxide. NfuA receives Fe-S clusters from IscU/HscBA and SufBCD scaffolds and eventually transfers them to the ATCs IscA and SufA. This study provides significant information on one of the Fe-S biogenesis factors that has been often used as a building block by ISC and/or SUF synthesizing organisms, including bacteria, plants and animals." @default.
- W2165626042 created "2016-06-24" @default.
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- W2165626042 date "2012-09-12" @default.
- W2165626042 modified "2023-10-18" @default.
- W2165626042 title "Molecular organization, biochemical function, cellular role and evolution of NfuA, an atypical Fe-S carrier" @default.
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- W2165626042 doi "https://doi.org/10.1111/j.1365-2958.2012.08181.x" @default.
- W2165626042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22966982" @default.
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