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- W2165629453 abstract "Cell morphogenesis in most bacteria is governed by spatiotemporal growth regulation of the peptidoglycan cell wall layer. Much is known about peptidoglycan synthesis but regulation of its turnover by hydrolytic enzymes is much less well understood. Bacillus subtilis has a multitude of such enzymes. Two of the best characterized are CwlO and LytE: cells lacking both enzymes have a lethal block in cell elongation. Here we show that activity of CwlO is regulated by an ABC transporter, FtsEX, which is required for cell elongation, unlike cell division as in Escherichia coli. Actin-like MreB proteins are thought to play a key role in orchestrating cell wall morphogenesis. B. subtilis has three MreB isologues with partially differentiated functions. We now show that the three MreB isologues have differential roles in regulation of the CwlO and LytE systems and that autolysins control different aspects of cell morphogenesis. The results add major autolytic activities to the growing list of functions controlled by MreB isologues in bacteria and provide new insights into the different specialized functions of essential cell wall autolysins." @default.
- W2165629453 created "2016-06-24" @default.
- W2165629453 creator A5033275201 @default.
- W2165629453 creator A5044426254 @default.
- W2165629453 creator A5062098632 @default.
- W2165629453 creator A5075392124 @default.
- W2165629453 date "2013-08-04" @default.
- W2165629453 modified "2023-10-04" @default.
- W2165629453 title "Differentiated roles for <scp>MreB</scp>‐actin isologues and autolytic enzymes in <i><scp>B</scp>acillus subtilis</i> morphogenesis" @default.
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- W2165629453 doi "https://doi.org/10.1111/mmi.12335" @default.
- W2165629453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3817527" @default.
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