Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165632078> ?p ?o ?g. }
- W2165632078 endingPage "4452" @default.
- W2165632078 startingPage "4441" @default.
- W2165632078 abstract "We previously described the identification of quail MafA, a novel transcription factor of the Maf bZIP (basic region leucine zipper) family, expressed in the differentiating neuroretina (NR). In the present study, we provide the first evidence that MafA is phosphorylated and that its biological properties strongly rely upon phosphorylation of serines 14 and 65, two residues located in the transcriptional activating domain within a consensus for phosphorylation by mitogen-activated protein kinases and which are conserved among Maf proteins. These residues are phosphorylated by ERK2 but not by p38, JNK, and ERK5 in vitro. However, the contribution of the MEK/ERK pathway to MafA phosphorylation in vivo appears to be moderate, implicating another kinase. The integrity of serine 14 and serine 65 residues is required for transcriptional activity, since their mutation into alanine severely impairs MafA capacity to activate transcription. Furthermore, we show that the MafA S14A/S65A mutant displays reduced capacity to induce expression of QR1, an NR-specific target of Maf proteins. Likewise, the integrity of serines 14 and 65 is essential for the MafA ability to stimulate expression of crystallin genes in NR cells and to induce NR-to-lens transdifferentiation. Thus, the MafA capacity to induce differentiation programs is dependent on its phosphorylation." @default.
- W2165632078 created "2016-06-24" @default.
- W2165632078 creator A5019093349 @default.
- W2165632078 creator A5042608007 @default.
- W2165632078 creator A5056921296 @default.
- W2165632078 creator A5067546546 @default.
- W2165632078 creator A5069734992 @default.
- W2165632078 creator A5077783321 @default.
- W2165632078 date "2001-07-01" @default.
- W2165632078 modified "2023-09-26" @default.
- W2165632078 title "Phosphorylation of MafA Is Essential for Its Transcriptional and Biological Properties" @default.
- W2165632078 cites W1487917997 @default.
- W2165632078 cites W1489145497 @default.
- W2165632078 cites W1693778124 @default.
- W2165632078 cites W1776293250 @default.
- W2165632078 cites W1810970627 @default.
- W2165632078 cites W1839183617 @default.
- W2165632078 cites W1873848645 @default.
- W2165632078 cites W1899552864 @default.
- W2165632078 cites W1964337986 @default.
- W2165632078 cites W1969759973 @default.
- W2165632078 cites W1973595140 @default.
- W2165632078 cites W1980473808 @default.
- W2165632078 cites W1984665850 @default.
- W2165632078 cites W1984841015 @default.
- W2165632078 cites W1984903682 @default.
- W2165632078 cites W1988369735 @default.
- W2165632078 cites W1988707760 @default.
- W2165632078 cites W1991254229 @default.
- W2165632078 cites W1991468020 @default.
- W2165632078 cites W1993983676 @default.
- W2165632078 cites W1994975139 @default.
- W2165632078 cites W1995941865 @default.
- W2165632078 cites W1998601884 @default.
- W2165632078 cites W2006295254 @default.
- W2165632078 cites W2009390451 @default.
- W2165632078 cites W2009578263 @default.
- W2165632078 cites W2018589311 @default.
- W2165632078 cites W2028472887 @default.
- W2165632078 cites W2043372546 @default.
- W2165632078 cites W2047285050 @default.
- W2165632078 cites W2050070176 @default.
- W2165632078 cites W2053010478 @default.
- W2165632078 cites W2053428527 @default.
- W2165632078 cites W2054887464 @default.
- W2165632078 cites W2056178963 @default.
- W2165632078 cites W2059773867 @default.
- W2165632078 cites W2063222008 @default.
- W2165632078 cites W2074366705 @default.
- W2165632078 cites W2077880395 @default.
- W2165632078 cites W2086525709 @default.
- W2165632078 cites W2087439863 @default.
- W2165632078 cites W2089256610 @default.
- W2165632078 cites W2091285777 @default.
- W2165632078 cites W2091611885 @default.
- W2165632078 cites W2101937406 @default.
- W2165632078 cites W2113737578 @default.
- W2165632078 cites W2120613348 @default.
- W2165632078 cites W2120925184 @default.
- W2165632078 cites W2121858619 @default.
- W2165632078 cites W2122510832 @default.
- W2165632078 cites W2133608451 @default.
- W2165632078 cites W2142638534 @default.
- W2165632078 cites W2144206181 @default.
- W2165632078 cites W2148467944 @default.
- W2165632078 cites W2148900936 @default.
- W2165632078 cites W2152761671 @default.
- W2165632078 cites W2155921150 @default.
- W2165632078 cites W2160471240 @default.
- W2165632078 cites W2161999936 @default.
- W2165632078 cites W2168259122 @default.
- W2165632078 cites W2335792027 @default.
- W2165632078 cites W2337658710 @default.
- W2165632078 cites W2396345288 @default.
- W2165632078 cites W4232042630 @default.
- W2165632078 cites W4376848581 @default.
- W2165632078 doi "https://doi.org/10.1128/mcb.21.14.4441-4452.2001" @default.
- W2165632078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/87104" @default.
- W2165632078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11416124" @default.
- W2165632078 hasPublicationYear "2001" @default.
- W2165632078 type Work @default.
- W2165632078 sameAs 2165632078 @default.
- W2165632078 citedByCount "86" @default.
- W2165632078 countsByYear W21656320782013 @default.
- W2165632078 countsByYear W21656320782014 @default.
- W2165632078 countsByYear W21656320782015 @default.
- W2165632078 countsByYear W21656320782016 @default.
- W2165632078 countsByYear W21656320782017 @default.
- W2165632078 countsByYear W21656320782018 @default.
- W2165632078 countsByYear W21656320782019 @default.
- W2165632078 countsByYear W21656320782020 @default.
- W2165632078 countsByYear W21656320782022 @default.
- W2165632078 countsByYear W21656320782023 @default.
- W2165632078 crossrefType "journal-article" @default.
- W2165632078 hasAuthorship W2165632078A5019093349 @default.
- W2165632078 hasAuthorship W2165632078A5042608007 @default.
- W2165632078 hasAuthorship W2165632078A5056921296 @default.
- W2165632078 hasAuthorship W2165632078A5067546546 @default.