FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165636895> ?p ?o ?g. }

• W2165636895 endingPage "3313" @default.
• W2165636895 startingPage "3307" @default.
• W2165636895 abstract "Using specific antagonists to rat interleukin (IL)-1 alpha and IL-1 beta, the roles of these IL-1s in endotoxin-induced suppression of plasma gonadotropin levels in freely-moving rats were studied. In orchiectomized rats, recombinant rat IL-1 alpha and IL-1 beta administered into the lateral ventricles almost equipotently suppressed plasma LH levels. Twenty five micrograms of bacterial endotoxin or lipopolysaccharide (LPS) administered similarly showed a comparable effect as that of 1 microgram IL-1 alpha or IL-1 beta, and completely lowered plasma LH levels by 60 min after the injection. To examine the roles of endogenous IL-1 alpha and IL-1 beta, anti-rat IL-1 alpha antiserum (anti-IL-1 alpha) and a recombinant human IL-1 receptor antagonist (IL-1ra) were used as specific blockers for IL-1 alpha and IL-1 beta, respectively. Anti-IL-1 alpha (10 microliters) or IL-1ra (10 micrograms) administered intracerebroventricularly (icv) with 25 micrograms LPS, significantly attenuated the LPS-induced effect on plasma LH levels during the first 60 min after LPS infusion, but not during the second 60 min. LPS at a dose of 5 micrograms induced smaller but still significant changes in plasma LH levels compared with 25 micrograms LPS or 1 microgram IL-1 beta. IL-1ra (10 micrograms) completely blocked LH suppression induced by 1 microgram IL-1 beta, but did not completely reverse the changes of LH induced by 5 micrograms LPS. IL-1ra injected iv also significantly attenuated the early suppressive effect of iv administered LPS, but not its late effect on plasma LH levels. However, iv administered IL-1ra had no influence on the effects of icv administered LPS. These data indicate that at least a part of plasma LH suppression caused by icv administered LPS is mediated via IL-1 alpha and IL-1 beta synthesized within the brain, while factor(s) other than IL-1 also participate in the LPS-induced change, particularly during the later period. A similar mechanism may also work peripherally in the case of iv administered LPS-induced plasma LH suppression." @default.
• W2165636895 created "2016-06-24" @default.
• W2165636895 creator A5007956503 @default.
• W2165636895 creator A5021975354 @default.
• W2165636895 creator A5052016150 @default.
• W2165636895 creator A5057936117 @default.
• W2165636895 creator A5060397148 @default.
• W2165636895 creator A5060533936 @default.
• W2165636895 creator A5063647434 @default.
• W2165636895 creator A5083039733 @default.
• W2165636895 creator A5086470073 @default.
• W2165636895 creator A5087606029 @default.
• W2165636895 date "1992-06-01" @default.
• W2165636895 modified "2023-09-26" @default.
• W2165636895 title "Roles of interleukin-1 alpha and -1 beta in endotoxin-induced suppression of plasma gonadotropin levels in rats." @default.
• W2165636895 doi "https://doi.org/10.1210/endo.130.6.1597143" @default.
• W2165636895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1597143" @default.
• W2165636895 hasPublicationYear "1992" @default.
• W2165636895 type Work @default.
• W2165636895 sameAs 2165636895 @default.
• W2165636895 citedByCount "54" @default.
• W2165636895 countsByYear W21656368952012 @default.
• W2165636895 countsByYear W21656368952013 @default.
• W2165636895 countsByYear W21656368952014 @default.
• W2165636895 countsByYear W21656368952015 @default.
• W2165636895 countsByYear W21656368952016 @default.
• W2165636895 countsByYear W21656368952017 @default.
• W2165636895 countsByYear W21656368952018 @default.
• W2165636895 countsByYear W21656368952019 @default.
• W2165636895 countsByYear W21656368952020 @default.
• W2165636895 countsByYear W21656368952022 @default.
• W2165636895 countsByYear W21656368952023 @default.
• W2165636895 crossrefType "journal-article" @default.
• W2165636895 hasAuthorship W2165636895A5007956503 @default.
• W2165636895 hasAuthorship W2165636895A5021975354 @default.
• W2165636895 hasAuthorship W2165636895A5052016150 @default.
• W2165636895 hasAuthorship W2165636895A5057936117 @default.
• W2165636895 hasAuthorship W2165636895A5060397148 @default.
• W2165636895 hasAuthorship W2165636895A5060533936 @default.
• W2165636895 hasAuthorship W2165636895A5063647434 @default.
• W2165636895 hasAuthorship W2165636895A5083039733 @default.
• W2165636895 hasAuthorship W2165636895A5086470073 @default.
• W2165636895 hasAuthorship W2165636895A5087606029 @default.
• W2165636895 hasBestOaLocation W21656368951 @default.
• W2165636895 hasConcept C126322002 @default.
• W2165636895 hasConcept C134018914 @default.
• W2165636895 hasConcept C149892131 @default.
• W2165636895 hasConcept C159110408 @default.
• W2165636895 hasConcept C170493617 @default.
• W2165636895 hasConcept C185592680 @default.
• W2165636895 hasConcept C199360897 @default.
• W2165636895 hasConcept C202751555 @default.
• W2165636895 hasConcept C2775944032 @default.
• W2165636895 hasConcept C2776174256 @default.
• W2165636895 hasConcept C2776885963 @default.
• W2165636895 hasConcept C2778122271 @default.
• W2165636895 hasConcept C2778690821 @default.
• W2165636895 hasConcept C2778754761 @default.
• W2165636895 hasConcept C2778782382 @default.
• W2165636895 hasConcept C41008148 @default.
• W2165636895 hasConcept C49453240 @default.
• W2165636895 hasConcept C51296783 @default.
• W2165636895 hasConcept C55493867 @default.
• W2165636895 hasConcept C64943373 @default.
• W2165636895 hasConcept C71315377 @default.
• W2165636895 hasConcept C71924100 @default.
• W2165636895 hasConcept C74172505 @default.
• W2165636895 hasConcept C86803240 @default.
• W2165636895 hasConceptScore W2165636895C126322002 @default.
• W2165636895 hasConceptScore W2165636895C134018914 @default.
• W2165636895 hasConceptScore W2165636895C149892131 @default.
• W2165636895 hasConceptScore W2165636895C159110408 @default.
• W2165636895 hasConceptScore W2165636895C170493617 @default.
• W2165636895 hasConceptScore W2165636895C185592680 @default.
• W2165636895 hasConceptScore W2165636895C199360897 @default.
• W2165636895 hasConceptScore W2165636895C202751555 @default.
• W2165636895 hasConceptScore W2165636895C2775944032 @default.
• W2165636895 hasConceptScore W2165636895C2776174256 @default.
• W2165636895 hasConceptScore W2165636895C2776885963 @default.
• W2165636895 hasConceptScore W2165636895C2778122271 @default.
• W2165636895 hasConceptScore W2165636895C2778690821 @default.
• W2165636895 hasConceptScore W2165636895C2778754761 @default.
• W2165636895 hasConceptScore W2165636895C2778782382 @default.
• W2165636895 hasConceptScore W2165636895C41008148 @default.
• W2165636895 hasConceptScore W2165636895C49453240 @default.
• W2165636895 hasConceptScore W2165636895C51296783 @default.
• W2165636895 hasConceptScore W2165636895C55493867 @default.
• W2165636895 hasConceptScore W2165636895C64943373 @default.
• W2165636895 hasConceptScore W2165636895C71315377 @default.
• W2165636895 hasConceptScore W2165636895C71924100 @default.
• W2165636895 hasConceptScore W2165636895C74172505 @default.
• W2165636895 hasConceptScore W2165636895C86803240 @default.
• W2165636895 hasIssue "6" @default.
• W2165636895 hasLocation W21656368951 @default.
• W2165636895 hasLocation W21656368952 @default.
• W2165636895 hasOpenAccess W2165636895 @default.
• W2165636895 hasPrimaryLocation W21656368951 @default.
• W2165636895 hasRelatedWork W1907786214 @default.

• next