FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165644577> ?p ?o ?g. }

• W2165644577 endingPage "1337" @default.
• W2165644577 startingPage "1321" @default.
• W2165644577 abstract "The combined effect of IL-4 and IL-2 on proliferation of anti-IgM antibody or Staphylococcus aureus strain Cowan I (SAC)-preactivated B cells was investigated. It was observed that in most cases, rIL-2 used at optimal concentration induced higher levels of tritiated thymidine ([3H]TdR) uptake than rIL-4 used at optimal concentration. When rIL-4 and rIL-2 were added together, it was repeatedly found that B cell proliferation induced by rIL-2 was significantly reduced and was, in most cases, comparable with the proliferation induced by rIL-4 alone. Cell cycle studies demonstrated that rIL-4 significantly reduced the number of cells entering S and G2/M phases of the cell cycle upon rIL-2 stimulation. B cell blasts preincubated for 24 or 48 h with rIL-4 displayed a reduced proliferation in response to rIL-2. In contrast, preculture of resting B cells with rIL-4 did not impair their subsequent proliferation in response to rIL-2 plus insolubilized anti-IgM antibody. This suggests that rIL-4 can only exert its inhibitory effect once B cells have received an activation signal. The differentiative activity of rIL-2 measured on B cell blasts preactivated for 2 d with SAC was not altered by rIL-4, which suggests that rIL-4 did not exert its inhibitory activity on rIL-2-induced B cell proliferation by enhancing rIL-2-mediated differentiation. Delayed addition of a neutralizing anti-IL-4 antiserum demonstrated that a period of contact of at least 24 h between IL-4 and B cell blasts was necessary for the development of the antagonistic effect of IL-4 on IL-2-mediated growth of activated B cells. These data demonstrate that IL-4 antagonizes the B cell growth-promoting effect of IL-2 without affecting the differentiation of preactivated B cells in response to IL-2." @default.
• W2165644577 created "2016-06-24" @default.
• W2165644577 creator A5002962815 @default.
• W2165644577 creator A5044500829 @default.
• W2165644577 creator A5048916540 @default.
• W2165644577 creator A5056900627 @default.
• W2165644577 date "1988-10-01" @default.
• W2165644577 modified "2023-10-15" @default.
• W2165644577 title "Interleukin 4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin 2." @default.
• W2165644577 cites W1491459289 @default.
• W2165644577 cites W1514777920 @default.
• W2165644577 cites W1539584528 @default.
• W2165644577 cites W1549748614 @default.
• W2165644577 cites W1553552126 @default.
• W2165644577 cites W1751935889 @default.
• W2165644577 cites W1771231716 @default.
• W2165644577 cites W1869933488 @default.
• W2165644577 cites W1894495795 @default.
• W2165644577 cites W1959472468 @default.
• W2165644577 cites W1960918491 @default.
• W2165644577 cites W1977043841 @default.
• W2165644577 cites W1980113529 @default.
• W2165644577 cites W1984893824 @default.
• W2165644577 cites W1984915036 @default.
• W2165644577 cites W2000246573 @default.
• W2165644577 cites W2004654501 @default.
• W2165644577 cites W2010670547 @default.
• W2165644577 cites W2015968307 @default.
• W2165644577 cites W2028784294 @default.
• W2165644577 cites W2032448671 @default.
• W2165644577 cites W2043018910 @default.
• W2165644577 cites W2048597344 @default.
• W2165644577 cites W2050583442 @default.
• W2165644577 cites W2053657535 @default.
• W2165644577 cites W2056267097 @default.
• W2165644577 cites W2063096720 @default.
• W2165644577 cites W2093107928 @default.
• W2165644577 cites W2093696506 @default.
• W2165644577 cites W2095343750 @default.
• W2165644577 cites W2114194173 @default.
• W2165644577 cites W2115945544 @default.
• W2165644577 cites W2123733931 @default.
• W2165644577 cites W2125753847 @default.
• W2165644577 cites W2126181905 @default.
• W2165644577 cites W2134828784 @default.
• W2165644577 cites W2146719176 @default.
• W2165644577 cites W2161829332 @default.
• W2165644577 cites W2163988580 @default.
• W2165644577 cites W2170300105 @default.
• W2165644577 cites W2171009645 @default.
• W2165644577 cites W2398147021 @default.
• W2165644577 doi "https://doi.org/10.1084/jem.168.4.1321" @default.
• W2165644577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2189093" @default.
• W2165644577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262709" @default.
• W2165644577 hasPublicationYear "1988" @default.
• W2165644577 type Work @default.
• W2165644577 sameAs 2165644577 @default.
• W2165644577 citedByCount "97" @default.
• W2165644577 countsByYear W21656445772013 @default.
• W2165644577 countsByYear W21656445772014 @default.
• W2165644577 crossrefType "journal-article" @default.
• W2165644577 hasAuthorship W2165644577A5002962815 @default.
• W2165644577 hasAuthorship W2165644577A5044500829 @default.
• W2165644577 hasAuthorship W2165644577A5048916540 @default.
• W2165644577 hasAuthorship W2165644577A5056900627 @default.
• W2165644577 hasBestOaLocation W21656445771 @default.
• W2165644577 hasConcept C134018914 @default.
• W2165644577 hasConcept C1491633281 @default.
• W2165644577 hasConcept C153911025 @default.
• W2165644577 hasConcept C159654299 @default.
• W2165644577 hasConcept C202751555 @default.
• W2165644577 hasConcept C203014093 @default.
• W2165644577 hasConcept C24998067 @default.
• W2165644577 hasConcept C2777108182 @default.
• W2165644577 hasConcept C55493867 @default.
• W2165644577 hasConcept C62112901 @default.
• W2165644577 hasConcept C85813293 @default.
• W2165644577 hasConcept C86803240 @default.
• W2165644577 hasConcept C91523082 @default.
• W2165644577 hasConceptScore W2165644577C134018914 @default.
• W2165644577 hasConceptScore W2165644577C1491633281 @default.
• W2165644577 hasConceptScore W2165644577C153911025 @default.
• W2165644577 hasConceptScore W2165644577C159654299 @default.
• W2165644577 hasConceptScore W2165644577C202751555 @default.
• W2165644577 hasConceptScore W2165644577C203014093 @default.
• W2165644577 hasConceptScore W2165644577C24998067 @default.
• W2165644577 hasConceptScore W2165644577C2777108182 @default.
• W2165644577 hasConceptScore W2165644577C55493867 @default.
• W2165644577 hasConceptScore W2165644577C62112901 @default.
• W2165644577 hasConceptScore W2165644577C85813293 @default.
• W2165644577 hasConceptScore W2165644577C86803240 @default.
• W2165644577 hasConceptScore W2165644577C91523082 @default.
• W2165644577 hasIssue "4" @default.
• W2165644577 hasLocation W21656445771 @default.
• W2165644577 hasLocation W21656445772 @default.
• W2165644577 hasLocation W21656445773 @default.
• W2165644577 hasLocation W21656445774 @default.
• W2165644577 hasOpenAccess W2165644577 @default.

• next