FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165651381> ?p ?o ?g. }

• W2165651381 endingPage "230" @default.
• W2165651381 startingPage "225" @default.
• W2165651381 abstract "Patients with allergic rhinitis (AR) show increased production of the Th2-related cytokines. Almost always, intranasal corticosteroid (INC) and antihistamine are used as routine therapy of AR. This study was performed to determine the in vitro secretion of cytokines profiles of PBMCs in patients with AR sensitive to Chenopodium album (Ch.a) pollens before and after treatment with INC (Fluticasone propionate) and oral antihistamine (Loratadine). PBMCs of 20 patients with AR, were tested in vitro for cytokine production. These cells were stimulated with natural or recombinant Ch.a. The levels of IL-4, IL-13 and IFN-, were measured in supernatants of cultured cell 96h after stimulation using ELISA. The PBMCs of 20 normal individuals were also similarly treared for comparison of results. The production of IL-4 by the patients' cells stimulated with either Ch.a or rCh.a was significantly higher than normal levels before therapy (p=0.04 and p=0.02, respectively). After therapy, a significant decrease in production of IL-4 and a significant increase in production of IL-10 were found in PBMCs stimulated with natural Ch.a, in comparison to the results before stimulation (p=0.03 for IL-4; p=0.04 for IL-10). Similarly, these results were seen in the production of IL-4 and IL-10 stimulated with rCh.a allergen after therapy in comparison to the results before stimulation (p=0.01 for IL-4; p=0.03 for IL-10). This study suggests INC (Fluticasone propionate) and oral antihistamine (Loratadine) have the capacity to inhibit the production of IL-4 and shift Th2/Th1 responses, probably due to increase the level of immunoregulatory IL-10. Therefore, it could be concluded that therapy with INC and antihistamine has pharmacologic and immunologic therapeutic effects on AR patients." @default.
• W2165651381 created "2016-06-24" @default.
• W2165651381 creator A5009207901 @default.
• W2165651381 creator A5014602432 @default.
• W2165651381 creator A5028354492 @default.
• W2165651381 creator A5038763454 @default.
• W2165651381 creator A5062724793 @default.
• W2165651381 creator A5074260389 @default.
• W2165651381 creator A5074508842 @default.
• W2165651381 creator A5080743188 @default.
• W2165651381 date "2010-12-01" @default.
• W2165651381 modified "2023-09-24" @default.
• W2165651381 title "Effect of treatment with intranasal corticosteroid and oral antihistamine on cytokine profiles of peripheral blood mononuclear cells of patients with allergic rhinitis sensitive to chenopodium album." @default.
• W2165651381 cites W1497022815 @default.
• W2165651381 cites W1969963951 @default.
• W2165651381 cites W2020335571 @default.
• W2165651381 cites W2026708946 @default.
• W2165651381 cites W2036943877 @default.
• W2165651381 cites W2052303532 @default.
• W2165651381 cites W20687422 @default.
• W2165651381 cites W2080331925 @default.
• W2165651381 cites W2082871366 @default.
• W2165651381 cites W2086782209 @default.
• W2165651381 cites W2088988612 @default.
• W2165651381 cites W2090644652 @default.
• W2165651381 cites W2096210343 @default.
• W2165651381 cites W2098404985 @default.
• W2165651381 cites W2114792473 @default.
• W2165651381 cites W2129692365 @default.
• W2165651381 cites W2131858351 @default.
• W2165651381 cites W2132665714 @default.
• W2165651381 cites W2143076511 @default.
• W2165651381 cites W2147770922 @default.
• W2165651381 cites W2164132449 @default.
• W2165651381 cites W2168986245 @default.
• W2165651381 cites W2305390477 @default.
• W2165651381 cites W2471242363 @default.
• W2165651381 cites W2506919309 @default.
• W2165651381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21131702" @default.
• W2165651381 hasPublicationYear "2010" @default.
• W2165651381 type Work @default.
• W2165651381 sameAs 2165651381 @default.
• W2165651381 citedByCount "2" @default.
• W2165651381 countsByYear W21656513812018 @default.
• W2165651381 crossrefType "journal-article" @default.
• W2165651381 hasAuthorship W2165651381A5009207901 @default.
• W2165651381 hasAuthorship W2165651381A5014602432 @default.
• W2165651381 hasAuthorship W2165651381A5028354492 @default.
• W2165651381 hasAuthorship W2165651381A5038763454 @default.
• W2165651381 hasAuthorship W2165651381A5062724793 @default.
• W2165651381 hasAuthorship W2165651381A5074260389 @default.
• W2165651381 hasAuthorship W2165651381A5074508842 @default.
• W2165651381 hasAuthorship W2165651381A5080743188 @default.
• W2165651381 hasConcept C126322002 @default.
• W2165651381 hasConcept C134018914 @default.
• W2165651381 hasConcept C137061746 @default.
• W2165651381 hasConcept C185592680 @default.
• W2165651381 hasConcept C202751555 @default.
• W2165651381 hasConcept C203014093 @default.
• W2165651381 hasConcept C24998067 @default.
• W2165651381 hasConcept C2776804153 @default.
• W2165651381 hasConcept C2776880894 @default.
• W2165651381 hasConcept C2778690821 @default.
• W2165651381 hasConcept C2779028295 @default.
• W2165651381 hasConcept C2780734495 @default.
• W2165651381 hasConcept C55493867 @default.
• W2165651381 hasConcept C71924100 @default.
• W2165651381 hasConcept C74172505 @default.
• W2165651381 hasConcept C85663871 @default.
• W2165651381 hasConcept C98274493 @default.
• W2165651381 hasConceptScore W2165651381C126322002 @default.
• W2165651381 hasConceptScore W2165651381C134018914 @default.
• W2165651381 hasConceptScore W2165651381C137061746 @default.
• W2165651381 hasConceptScore W2165651381C185592680 @default.
• W2165651381 hasConceptScore W2165651381C202751555 @default.
• W2165651381 hasConceptScore W2165651381C203014093 @default.
• W2165651381 hasConceptScore W2165651381C24998067 @default.
• W2165651381 hasConceptScore W2165651381C2776804153 @default.
• W2165651381 hasConceptScore W2165651381C2776880894 @default.
• W2165651381 hasConceptScore W2165651381C2778690821 @default.
• W2165651381 hasConceptScore W2165651381C2779028295 @default.
• W2165651381 hasConceptScore W2165651381C2780734495 @default.
• W2165651381 hasConceptScore W2165651381C55493867 @default.
• W2165651381 hasConceptScore W2165651381C71924100 @default.
• W2165651381 hasConceptScore W2165651381C74172505 @default.
• W2165651381 hasConceptScore W2165651381C85663871 @default.
• W2165651381 hasConceptScore W2165651381C98274493 @default.
• W2165651381 hasIssue "4" @default.
• W2165651381 hasLocation W21656513811 @default.
• W2165651381 hasLocation W21656513812 @default.
• W2165651381 hasOpenAccess W2165651381 @default.
• W2165651381 hasPrimaryLocation W21656513811 @default.
• W2165651381 hasRelatedWork W162137850 @default.
• W2165651381 hasRelatedWork W1982421576 @default.
• W2165651381 hasRelatedWork W2009836047 @default.
• W2165651381 hasRelatedWork W2027964945 @default.
• W2165651381 hasRelatedWork W2034771968 @default.
• W2165651381 hasRelatedWork W2043880077 @default.

• next