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• W2165659747 abstract "Inhibitors of DNA topoisomerases I and II induced arrest in cell division in normal human fibroblasts depending on cell divisions. Arrested cells showed morphology similar to those of normally senesced cells and strongly induced senescence-associated beta-galactosidase. In these cells, p16ink4a was upregulated, whereas p21waf1 or p53 was not altered. Upon removal of the inhibitors, the cells resumed growth but their cumulative population doublings were reduced dose dependently. Accelerated telomere shortening was not observed in the arrested cells. These results suggest that DNA topoisomerase inhibitors are efficient and reversible inducers of premature senescence in normal human cells." @default.
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• W2165659747 date "1998-12-01" @default.
• W2165659747 modified "2023-09-26" @default.
• W2165659747 title "DNA Topoisomerase Inhibitors Induce Reversible Senescence in Normal Human Fibroblasts" @default.
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• W2165659747 doi "https://doi.org/10.1006/bbrc.1998.9832" @default.
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