Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165675667> ?p ?o ?g. }
- W2165675667 abstract "We conducted a controlled trial of recombinant human GH (rhGH) in 27 healthy elderly women (66.7 +/- 3.0 yr), of whom 8 took a stable dose of replacement estrogen throughout the study (plus estrogen group). Hormone or placebo was given as a single daily injection. A total of 19 women were assigned to receive rhGH at an initial daily dose of 0.043 mg/kg BW. After several weeks, 50% dose reductions were necessitated by side-effects. The last 7 subjects to be enrolled began treatment at this reduced level. A total of 13 women assigned to rhGH and 14 women assigned to placebo completed 6 months of drug treatment. In the rhGH group, 6 women took estrogen; thus, the effects of rhGH were assessed separately by estrogen status. Circulating insulin-like growth factor-I (IGF-I) levels were similar at baseline (rhGH, 133 +/- 40.4 micrograms/L; placebo, 128 +/- 13). rhGH increased IGF-I and IGF-I-binding protein-3 (IGFBP-3) in all subjects [6 month IGF-I in plus estrogen women, 230 +/- 25.4 micrograms/L; in those not receiving estrogen (minus estrogen), 308 +/- 21.3]. No changes in IGF-I or IGFBP-3 occurred with placebo (IGF-I, 144 +/- 21.3 micrograms/L). Skinfold thickness measurements showed an 11% decrease in fat mass (P < 0.005) and a 9% decrease in percent fat after 6 months of rhGH treatment. No significant difference in nitrogen balance was seen in either group at 6 months, but rhGH increased creatinine clearance by 9.2% (P < 0.05). rhGH dramatically increased markers of bone turnover, with more pronounced effects in minus estrogen women. Hydroxyproline excretion increased by 20% and 80%, and pyridinoline excretion increased by 44% and 75% in plus and minus estrogen subgroups, respectively. Osteocalcin concentrations increased by more than 60% in minus estrogen women (P < 0.05), but did not change in the plus estrogen group. No changes were observed in circulating type I procollagen extension peptide in either group, and no change in any turnover marker was seen in the placebo group. rhGH did not alter blood pressure or circulating L-T4 levels, but a transient increase in serum T3 was observed in the minus estrogen group at 3 months. rhGH decreased low density lipoprotein cholesterol in the minus estrogen group, but otherwise no significant changes in circulating lipoproteins or fibrinogen were observed. Eight women assigned to rhGH and 14 placebo-treated women remained on blinded treatment through 12 months.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W2165675667 created "2016-06-24" @default.
- W2165675667 creator A5004962376 @default.
- W2165675667 creator A5015296880 @default.
- W2165675667 creator A5049045696 @default.
- W2165675667 creator A5074899999 @default.
- W2165675667 creator A5075302749 @default.
- W2165675667 date "1994-08-01" @default.
- W2165675667 modified "2023-10-17" @default.
- W2165675667 title "Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women." @default.
- W2165675667 cites W1497043782 @default.
- W2165675667 cites W1564037175 @default.
- W2165675667 cites W1963817487 @default.
- W2165675667 cites W1964531562 @default.
- W2165675667 cites W1973586346 @default.
- W2165675667 cites W1973679016 @default.
- W2165675667 cites W1987910229 @default.
- W2165675667 cites W1989069669 @default.
- W2165675667 cites W1995555012 @default.
- W2165675667 cites W1998010052 @default.
- W2165675667 cites W2003552730 @default.
- W2165675667 cites W2004236425 @default.
- W2165675667 cites W2006760737 @default.
- W2165675667 cites W2014313472 @default.
- W2165675667 cites W2014633710 @default.
- W2165675667 cites W2027131411 @default.
- W2165675667 cites W2028182259 @default.
- W2165675667 cites W2036527519 @default.
- W2165675667 cites W2038838869 @default.
- W2165675667 cites W2041811148 @default.
- W2165675667 cites W2047190176 @default.
- W2165675667 cites W2049287362 @default.
- W2165675667 cites W2050386090 @default.
- W2165675667 cites W2052533937 @default.
- W2165675667 cites W2054548024 @default.
- W2165675667 cites W2055397537 @default.
- W2165675667 cites W2055606107 @default.
- W2165675667 cites W2059716163 @default.
- W2165675667 cites W2067621258 @default.
- W2165675667 cites W2072573450 @default.
- W2165675667 cites W2077150151 @default.
- W2165675667 cites W2079333525 @default.
- W2165675667 cites W2081047941 @default.
- W2165675667 cites W2087551597 @default.
- W2165675667 cites W2097387202 @default.
- W2165675667 cites W2107880912 @default.
- W2165675667 cites W2119150168 @default.
- W2165675667 cites W2124767441 @default.
- W2165675667 cites W2125204388 @default.
- W2165675667 cites W2133406706 @default.
- W2165675667 cites W2134109634 @default.
- W2165675667 cites W2141404241 @default.
- W2165675667 cites W2161642359 @default.
- W2165675667 cites W2181043099 @default.
- W2165675667 cites W2315987042 @default.
- W2165675667 cites W2336678594 @default.
- W2165675667 cites W2341183108 @default.
- W2165675667 cites W2408119528 @default.
- W2165675667 doi "https://doi.org/10.1210/jcem.79.2.7519191" @default.
- W2165675667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7519191" @default.
- W2165675667 hasPublicationYear "1994" @default.
- W2165675667 type Work @default.
- W2165675667 sameAs 2165675667 @default.
- W2165675667 citedByCount "95" @default.
- W2165675667 countsByYear W21656756672013 @default.
- W2165675667 countsByYear W21656756672014 @default.
- W2165675667 countsByYear W21656756672019 @default.
- W2165675667 countsByYear W21656756672022 @default.
- W2165675667 crossrefType "journal-article" @default.
- W2165675667 hasAuthorship W2165675667A5004962376 @default.
- W2165675667 hasAuthorship W2165675667A5015296880 @default.
- W2165675667 hasAuthorship W2165675667A5049045696 @default.
- W2165675667 hasAuthorship W2165675667A5074899999 @default.
- W2165675667 hasAuthorship W2165675667A5075302749 @default.
- W2165675667 hasConcept C126322002 @default.
- W2165675667 hasConcept C134018914 @default.
- W2165675667 hasConcept C142724271 @default.
- W2165675667 hasConcept C204787440 @default.
- W2165675667 hasConcept C27081682 @default.
- W2165675667 hasConcept C2777164284 @default.
- W2165675667 hasConcept C2779306644 @default.
- W2165675667 hasConcept C71924100 @default.
- W2165675667 hasConcept C89551170 @default.
- W2165675667 hasConceptScore W2165675667C126322002 @default.
- W2165675667 hasConceptScore W2165675667C134018914 @default.
- W2165675667 hasConceptScore W2165675667C142724271 @default.
- W2165675667 hasConceptScore W2165675667C204787440 @default.
- W2165675667 hasConceptScore W2165675667C27081682 @default.
- W2165675667 hasConceptScore W2165675667C2777164284 @default.
- W2165675667 hasConceptScore W2165675667C2779306644 @default.
- W2165675667 hasConceptScore W2165675667C71924100 @default.
- W2165675667 hasConceptScore W2165675667C89551170 @default.
- W2165675667 hasLocation W21656756671 @default.
- W2165675667 hasLocation W21656756672 @default.
- W2165675667 hasOpenAccess W2165675667 @default.
- W2165675667 hasPrimaryLocation W21656756671 @default.
- W2165675667 hasRelatedWork W1982445799 @default.
- W2165675667 hasRelatedWork W1983641721 @default.
- W2165675667 hasRelatedWork W1984236882 @default.
- W2165675667 hasRelatedWork W2026226896 @default.