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• W2165688675 endingPage "1658" @default.
• W2165688675 startingPage "1647" @default.
• W2165688675 abstract "FGF regulates both cell migration and proliferation by receptor-dependent induction of immediate-early gene expression and tyrosine phosphorylation of intracellular polypeptides. Because little is known about the disparate nature of intracellular signaling pathways, which are able to discriminate between cell migration and proliferation, we used a washout strategy to examine the relationship between immediate-early gene expression and tyrosine phosphorylation with respect to the potential of cells either to migrate or to initiate DNA synthesis in response to FGF-1. We demonstrate that transient exposure to FGF-1 results in a significant decrease in Fos transcript expression and a decrease in tyrosine phosphorylation of the FGFR-1, p42(mapk), and p44(mapk). Consistent with these biochemical effects, we demonstrate that attenuation in the level of DNA synthesis such that a 1.5-h withdrawal is sufficient to return the population to a state similar to quiescence. In contrast, the level of Myc mRNA, the activity of Src, the tyrosine phosphorylation of cortactin, and the FGF-1-induced redistribution of cortactin and F-actin were unaffected by transient FGF-1 stimulation. These biochemical responses are consistent with an implied uncompromised migratory potential of the cells in response to growth factor withdrawal. These results suggest a correlation between Fos expression and the mitogen-activated protein kinase pathway with initiation of DNA synthesis and a correlation between high levels of Myc mRNA and Src kinase activity with the regulation of cell migration." @default.
• W2165688675 created "2016-06-24" @default.
• W2165688675 creator A5008501364 @default.
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• W2165688675 creator A5056046766 @default.
• W2165688675 creator A5061858226 @default.
• W2165688675 creator A5066301151 @default.
• W2165688675 date "1998-06-29" @default.
• W2165688675 modified "2023-09-25" @default.
• W2165688675 title "Activation of the MAP Kinase Pathway by FGF-1 Correlates with Cell Proliferation Induction While Activation of the Src Pathway Correlates with Migration" @default.
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• W2165688675 doi "https://doi.org/10.1083/jcb.141.7.1647" @default.
• W2165688675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2133001" @default.
• W2165688675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9647656" @default.
• W2165688675 hasPublicationYear "1998" @default.
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