FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165713254> ?p ?o ?g. }

• W2165713254 endingPage "R65" @default.
• W2165713254 startingPage "R65" @default.
• W2165713254 abstract "Splice donor sites have a highly conserved GT or GC dinucleotide and an extended intronic consensus sequence GTRAGT that reflects the sequence complementarity to the U1 snRNA. Here, we focus on unusual donor sites with the motif GYNGYN (Y stands for C or T; N stands for A, C, G, or T). While only one GY functions as a splice donor for the majority of these splice sites in human, we provide computational and experimental evidence that 110 (1.3%) allow alternative splicing at both GY donors. The resulting splice forms differ in only three nucleotides, which results mostly in the insertion/deletion of one amino acid. However, we also report the insertion of a stop codon in four cases. Investigating what distinguishes alternatively from not alternatively spliced GYNGYN donors, we found differences in the binding to U1 snRNA, a strong correlation between U1 snRNA binding strength and the preferred donor, over-represented sequence motifs in the adjacent introns, and a higher conservation of the exonic and intronic flanks between human and mouse. Extending our genome-wide analysis to seven other eukaryotic species, we found alternatively spliced GYNGYN donors in all species from mouse to Caenorhabditis elegans and even in Arabidopsis thaliana. Experimental verification of a conserved GTAGTT donor of the STAT3 gene in human and mouse reveals a remarkably similar ratio of alternatively spliced transcripts in both species. In contrast to alternative splicing in general, GYNGYN donors in addition to NAGNAG acceptors enable subtle protein variations." @default.
• W2165713254 created "2016-06-24" @default.
• W2165713254 creator A5017672883 @default.
• W2165713254 creator A5041994630 @default.
• W2165713254 creator A5042480855 @default.
• W2165713254 creator A5054564152 @default.
• W2165713254 creator A5059435501 @default.
• W2165713254 creator A5078189933 @default.
• W2165713254 creator A5089733480 @default.
• W2165713254 date "2006-01-01" @default.
• W2165713254 modified "2023-10-18" @default.
• W2165713254 cites W1507116771 @default.
• W2165713254 cites W1561999446 @default.
• W2165713254 cites W1599357356 @default.
• W2165713254 cites W1896595148 @default.
• W2165713254 cites W1898021946 @default.
• W2165713254 cites W1913751664 @default.
• W2165713254 cites W1963793607 @default.
• W2165713254 cites W1963918734 @default.
• W2165713254 cites W1970774008 @default.
• W2165713254 cites W1971158461 @default.
• W2165713254 cites W1975142744 @default.
• W2165713254 cites W1977343146 @default.
• W2165713254 cites W1985094434 @default.
• W2165713254 cites W1987564626 @default.
• W2165713254 cites W1991703748 @default.
• W2165713254 cites W1994515228 @default.
• W2165713254 cites W1994939362 @default.
• W2165713254 cites W2002519661 @default.
• W2165713254 cites W2003016053 @default.
• W2165713254 cites W2008117561 @default.
• W2165713254 cites W2008467118 @default.
• W2165713254 cites W2013590496 @default.
• W2165713254 cites W2016273505 @default.
• W2165713254 cites W2017304814 @default.
• W2165713254 cites W2023126119 @default.
• W2165713254 cites W2023506303 @default.
• W2165713254 cites W2023648355 @default.
• W2165713254 cites W2024039709 @default.
• W2165713254 cites W2024588724 @default.
• W2165713254 cites W2033310094 @default.
• W2165713254 cites W2034691490 @default.
• W2165713254 cites W2034964253 @default.
• W2165713254 cites W2041918235 @default.
• W2165713254 cites W2048782540 @default.
• W2165713254 cites W2069724339 @default.
• W2165713254 cites W2070851162 @default.
• W2165713254 cites W2074090002 @default.
• W2165713254 cites W2075675982 @default.
• W2165713254 cites W2077199821 @default.
• W2165713254 cites W2089054940 @default.
• W2165713254 cites W2089465951 @default.
• W2165713254 cites W2096940705 @default.
• W2165713254 cites W2097605211 @default.
• W2165713254 cites W2100852196 @default.
• W2165713254 cites W2102823772 @default.
• W2165713254 cites W2104434844 @default.
• W2165713254 cites W2113267877 @default.
• W2165713254 cites W2114858580 @default.
• W2165713254 cites W2117526725 @default.
• W2165713254 cites W2118600301 @default.
• W2165713254 cites W2122992197 @default.
• W2165713254 cites W2133199944 @default.
• W2165713254 cites W2134650102 @default.
• W2165713254 cites W2145070407 @default.
• W2165713254 cites W2145382902 @default.
• W2165713254 cites W2149109499 @default.
• W2165713254 cites W2150083385 @default.
• W2165713254 cites W2158266834 @default.
• W2165713254 cites W2158463967 @default.
• W2165713254 cites W2159509917 @default.
• W2165713254 cites W2159864549 @default.
• W2165713254 cites W2162396524 @default.
• W2165713254 cites W2164791845 @default.
• W2165713254 cites W2165954869 @default.
• W2165713254 cites W2168909179 @default.
• W2165713254 cites W2915985519 @default.
• W2165713254 doi "https://doi.org/10.1186/gb-2006-7-7-r65" @default.
• W2165713254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1779574" @default.
• W2165713254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16869967" @default.
• W2165713254 hasPublicationYear "2006" @default.
• W2165713254 type Work @default.
• W2165713254 sameAs 2165713254 @default.
• W2165713254 citedByCount "34" @default.
• W2165713254 countsByYear W21657132542012 @default.
• W2165713254 countsByYear W21657132542013 @default.
• W2165713254 countsByYear W21657132542014 @default.
• W2165713254 countsByYear W21657132542015 @default.
• W2165713254 countsByYear W21657132542016 @default.
• W2165713254 countsByYear W21657132542019 @default.
• W2165713254 countsByYear W21657132542021 @default.
• W2165713254 countsByYear W21657132542022 @default.
• W2165713254 crossrefType "journal-article" @default.
• W2165713254 hasAuthorship W2165713254A5017672883 @default.
• W2165713254 hasAuthorship W2165713254A5041994630 @default.
• W2165713254 hasAuthorship W2165713254A5042480855 @default.
• W2165713254 hasAuthorship W2165713254A5054564152 @default.
• W2165713254 hasAuthorship W2165713254A5059435501 @default.

• next