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• W2165733650 endingPage "3471" @default.
• W2165733650 startingPage "3463" @default.
• W2165733650 abstract "Proteins of the SNARE (soluble N-ethylmalemide-sensitive factor attachment protein receptor) family are essential for the fusion of transport vesicles with an acceptor membrane. Despite considerable sequence divergence, their mechanism of action is conserved: heterologous sets assemble into membrane-bridging SNARE complexes, in effect driving membrane fusion. Within the cell, distinct functional SNARE units are involved in different trafficking steps. These functional units are conserved across species and probably reflect the conservation of the particular transport step. Here, we have systematically analyzed SNARE sequences from 145 different species and have established a highly accurate classification for all SNARE proteins. Principally, all SNAREs split into four basic types, reflecting their position in the four-helix bundle complex. Among these four basic types, we established 20 SNARE subclasses that probably represent the original repertoire of a eukaryotic cenancestor. This repertoire has been modulated independently in different lines of organisms. Our data are in line with the notion that the ur-eukaryotic cell was already equipped with the various compartments found in contemporary cells. Possibly, the development of these compartments is closely intertwined with episodes of duplication and divergence of a prototypic SNARE unit." @default.
• W2165733650 created "2016-06-24" @default.
• W2165733650 creator A5012826233 @default.
• W2165733650 creator A5042280512 @default.
• W2165733650 creator A5080159031 @default.
• W2165733650 date "2007-09-01" @default.
• W2165733650 modified "2023-10-14" @default.
• W2165733650 title "An Elaborate Classification of SNARE Proteins Sheds Light on the Conservation of the Eukaryotic Endomembrane System" @default.
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• W2165733650 doi "https://doi.org/10.1091/mbc.e07-03-0193" @default.
• W2165733650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1951749" @default.
• W2165733650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17596510" @default.
• W2165733650 hasPublicationYear "2007" @default.
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