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• W2165734886 endingPage "1112" @default.
• W2165734886 startingPage "1099" @default.
• W2165734886 abstract "The human papillomavirus type 16 (HPV16) E7 is a major viral oncoprotein that is phosphorylated by casein kinase II (CKII). Two S100 family calcium-binding proteins, macrophage inhibitory-related factor protein 8 (MRP-8) and MRP-14, form a protein complex, MRP-8/14, that inactivates CKII. The MRP-8/14 protein complex may inhibit CKII-mediated E7 phosphorylation and therefore may alter its interaction with cellular ligands and reduce E7 oncogenic activity. We examined the inhibitory effect of the MRP-8/14 complex on CKII activity and HPV16 E7 phosphorylation. We have shown that CKII activity and HPV16 E7 phosphorylation were inhibited by uptake of exogenous MRP-8/14 and activation of endogenous MRP-8/14. MRP-8/14-mediated inhibition of E7 phosphorylation occurred at the G1 phase of the cell cycle. Analysis of MRP expression in primary keratinocytes and in HPV16- and 18-transformed cervical and foreskin epithelial cell lines showed that expression of MRP-8, MRP-14, and the MRP-8/14 complex was detected only in primary untransformed keratinocytes and not in the HPV-infected immortalized epithelial cells. CKII activity in HPV-immortalized keratinocytes was approximately fourfold higher than in HPV-negative primary keratinocytes. Treatment of HPV-positive immortalized epithelial cells with exogenous MRP-8/14 resulted in E7 hypophosphorylation and complete inhibition of cell growth within 2 weeks, compared with HPV-negative primary and immortalized HPV-negative cervical epithelial cells, which showed 25 and 40% growth inhibition, respectively. Together these results suggests that the MRP-8/14 protein complex in HPV-infected epithelial cells may play an important role in regulation of CKII-mediated E7 phosphorylation and inhibition of its oncogenic activity." @default.
• W2165734886 created "2016-06-24" @default.
• W2165734886 creator A5040659416 @default.
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• W2165734886 date "2005-01-15" @default.
• W2165734886 modified "2023-10-18" @default.
• W2165734886 title "Inhibition of Human Papillomavirus Type 16 E7 Phosphorylation by the S100 MRP-8/14 Protein Complex" @default.
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• W2165734886 cites W1606815882 @default.
• W2165734886 cites W164275246 @default.
• W2165734886 cites W1660611080 @default.
• W2165734886 cites W1756522554 @default.
• W2165734886 cites W1831319429 @default.
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• W2165734886 cites W1968329569 @default.
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• W2165734886 doi "https://doi.org/10.1128/jvi.79.2.1099-1112.2005" @default.
• W2165734886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/538578" @default.
• W2165734886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15613338" @default.
• W2165734886 hasPublicationYear "2005" @default.
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