FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165735298> ?p ?o ?g. }

• W2165735298 endingPage "1325" @default.
• W2165735298 startingPage "1314" @default.
• W2165735298 abstract "The anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective dimension of pain. Although much evidence has pointed to an increased excitatory synaptic transmission in the ACC in some of the pathological pain state, the inhibitory synaptic transmission in this process has not been well studied. Also, the overall changes of excitatory and inhibitory synaptic transmission have not been comparatively studied in an animal model displaying both long-term persistent nociception and hyperalgesia. Here we used patch clamp recordings in ACC brain slices to observe the changes in synaptic transmission in a pain model induced by peripheral bee venom injection. First, we show that, comparing with those of naive and saline controlled rats, there was a significant increase in spike frequency in ACC neurons harvested from rats after 2 h period of peripheral persistent painful stimuli. Second, it is further shown that the frequency, amplitude and half-width were all increased in spontaneous excitatory post-synaptic currents (sEPSCs), while the amplitude of spontaneous inhibitory post-synaptic currents (sIPSCs) was decreased. The recordings of miniature post-synaptic currents demonstrate an increase in frequency of miniature excitatory post-synaptic currents (mEPSCs) and a decrease in both frequency and amplitude of miniature inhibitory post-synaptic currents (mIPSCs) in rats' ACC slice of bee venom treatment. Taken together, the present results demonstrate an unparalleled change between excitatory and inhibitory synaptic transmission in the ACC under a state of peripheral persistent nociception that might be underlying mechanisms of the excessive excitability of the ACC neurons. We propose that the painful stimuli when lasts or becomes persistent may cause a disruption of the balance between excitatory and inhibitory synaptic transmission that can contribute to the functional change in the ACC." @default.
• W2165735298 created "2016-06-24" @default.
• W2165735298 creator A5009040535 @default.
• W2165735298 creator A5014311869 @default.
• W2165735298 creator A5017838591 @default.
• W2165735298 creator A5043476689 @default.
• W2165735298 creator A5049081049 @default.
• W2165735298 creator A5056248198 @default.
• W2165735298 creator A5065670524 @default.
• W2165735298 creator A5076246947 @default.
• W2165735298 creator A5085043458 @default.
• W2165735298 creator A5090616153 @default.
• W2165735298 date "2010-12-01" @default.
• W2165735298 modified "2023-10-08" @default.
• W2165735298 title "Enhanced excitatory and reduced inhibitory synaptic transmission contribute to persistent pain-induced neuronal hyper-responsiveness in anterior cingulate cortex" @default.
• W2165735298 cites W1489033370 @default.
• W2165735298 cites W1540290822 @default.
• W2165735298 cites W1545279515 @default.
• W2165735298 cites W1567615855 @default.
• W2165735298 cites W1608318158 @default.
• W2165735298 cites W1664245680 @default.
• W2165735298 cites W1881300191 @default.
• W2165735298 cites W1921337837 @default.
• W2165735298 cites W1963735148 @default.
• W2165735298 cites W1965127814 @default.
• W2165735298 cites W1974300877 @default.
• W2165735298 cites W1980369017 @default.
• W2165735298 cites W1980854480 @default.
• W2165735298 cites W1983177659 @default.
• W2165735298 cites W1985167253 @default.
• W2165735298 cites W1995158551 @default.
• W2165735298 cites W1997151932 @default.
• W2165735298 cites W1997299990 @default.
• W2165735298 cites W1998587100 @default.
• W2165735298 cites W2001615001 @default.
• W2165735298 cites W2005426034 @default.
• W2165735298 cites W2009073501 @default.
• W2165735298 cites W2009399717 @default.
• W2165735298 cites W2016144009 @default.
• W2165735298 cites W2019082225 @default.
• W2165735298 cites W2020348231 @default.
• W2165735298 cites W2021260465 @default.
• W2165735298 cites W2023136152 @default.
• W2165735298 cites W2034621486 @default.
• W2165735298 cites W2034736385 @default.
• W2165735298 cites W2035710003 @default.
• W2165735298 cites W2035918259 @default.
• W2165735298 cites W2039461704 @default.
• W2165735298 cites W2044403322 @default.
• W2165735298 cites W2044444207 @default.
• W2165735298 cites W2045889198 @default.
• W2165735298 cites W2055187944 @default.
• W2165735298 cites W2056565769 @default.
• W2165735298 cites W2057684612 @default.
• W2165735298 cites W2063223361 @default.
• W2165735298 cites W2064533533 @default.
• W2165735298 cites W2069197908 @default.
• W2165735298 cites W2075715784 @default.
• W2165735298 cites W2079840847 @default.
• W2165735298 cites W2080076872 @default.
• W2165735298 cites W2083867141 @default.
• W2165735298 cites W2085955270 @default.
• W2165735298 cites W2087454739 @default.
• W2165735298 cites W2089808556 @default.
• W2165735298 cites W2089991897 @default.
• W2165735298 cites W2092949773 @default.
• W2165735298 cites W2094795912 @default.
• W2165735298 cites W2095199744 @default.
• W2165735298 cites W2109173536 @default.
• W2165735298 cites W2112240784 @default.
• W2165735298 cites W2114455248 @default.
• W2165735298 cites W2115702038 @default.
• W2165735298 cites W2116888010 @default.
• W2165735298 cites W2117329255 @default.
• W2165735298 cites W2119350643 @default.
• W2165735298 cites W2124811217 @default.
• W2165735298 cites W2126493020 @default.
• W2165735298 cites W2127983299 @default.
• W2165735298 cites W2131165483 @default.
• W2165735298 cites W2135799745 @default.
• W2165735298 cites W2137048847 @default.
• W2165735298 cites W2144607109 @default.
• W2165735298 cites W2145780484 @default.
• W2165735298 cites W2148792824 @default.
• W2165735298 cites W2149507347 @default.
• W2165735298 cites W2150321495 @default.
• W2165735298 cites W2150476194 @default.
• W2165735298 cites W2158274511 @default.
• W2165735298 cites W2164606425 @default.
• W2165735298 cites W2167987357 @default.
• W2165735298 cites W2169449669 @default.
• W2165735298 cites W2170380292 @default.
• W2165735298 cites W2340200357 @default.
• W2165735298 cites W4247612403 @default.
• W2165735298 cites W77091309 @default.
• W2165735298 cites W78173492 @default.
• W2165735298 doi "https://doi.org/10.1016/j.neuroscience.2010.10.028" @default.
• W2165735298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20951771" @default.

• next