FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165762516> ?p ?o ?g. }

• W2165762516 endingPage "266" @default.
• W2165762516 startingPage "257" @default.
• W2165762516 abstract "Neurofibrillary tangles, one of the pathologic hallmarks of Alzheimer's disease (AD), are composed of abnormally polymerized tau protein. The hyperphosphorylation of tau alters its normal cellular function and is thought to promote the formation of neurofibrillary tangles. Growing evidence suggests that cyclin-dependent kinase 5 (cdk5) plays a role in tau phosphorylation, but the function of the enzyme in tangle formation remains uncertain. In AD, cdk5 is constitutively activated by p25, a highly stable, 25kD protein thought to be increased in the AD brain. To test the hypothesis that p25/cdk5 interactions promote neurofibrillary pathology, we created transgenic mouse lines that overexpress the human p25 protein specifically in neurons. Mice with high transgenic p25 expression have augmented cdk5 activity and develop severe hindlimb semiparalysis and mild forelimb dyskinesia beginning at approximately 3 months of age. Immunohistochemical and ultrastructural analyses showed widespread axonal degeneration with focal accumulation of tau in various regions of the brain and, to a lesser extent, the spinal cord. However, there was no evidence of neurofibrillary tangles in neuronal somata or axons, nor were paired helical filaments evident ultrastructurally. These studies confirm that p25 overexpression can lead to tau abnormalities and axonal degeneration in vivo but do not support the hypothesis that p25-related induction of cdk5 is a primary event in the genesis of neurofibrillary tangles." @default.
• W2165762516 created "2016-06-24" @default.
• W2165762516 creator A5003243415 @default.
• W2165762516 creator A5017808777 @default.
• W2165762516 creator A5028360919 @default.
• W2165762516 creator A5043062540 @default.
• W2165762516 creator A5043543559 @default.
• W2165762516 creator A5046762961 @default.
• W2165762516 creator A5059902188 @default.
• W2165762516 creator A5082703770 @default.
• W2165762516 creator A5091276158 @default.
• W2165762516 date "2002-03-22" @default.
• W2165762516 modified "2023-10-18" @default.
• W2165762516 title "Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice" @default.
• W2165762516 cites W1480786153 @default.
• W2165762516 cites W1504754156 @default.
• W2165762516 cites W1511517753 @default.
• W2165762516 cites W1528219518 @default.
• W2165762516 cites W1563116834 @default.
• W2165762516 cites W1568595238 @default.
• W2165762516 cites W1575595760 @default.
• W2165762516 cites W1971642895 @default.
• W2165762516 cites W1972114796 @default.
• W2165762516 cites W1973774127 @default.
• W2165762516 cites W1975040221 @default.
• W2165762516 cites W1980389635 @default.
• W2165762516 cites W1982487434 @default.
• W2165762516 cites W1984732054 @default.
• W2165762516 cites W1994030229 @default.
• W2165762516 cites W1994336523 @default.
• W2165762516 cites W1995515835 @default.
• W2165762516 cites W2000983899 @default.
• W2165762516 cites W2009204794 @default.
• W2165762516 cites W2009945323 @default.
• W2165762516 cites W2014456898 @default.
• W2165762516 cites W2014898742 @default.
• W2165762516 cites W2021590064 @default.
• W2165762516 cites W2021753155 @default.
• W2165762516 cites W2025425293 @default.
• W2165762516 cites W2028570069 @default.
• W2165762516 cites W2030804652 @default.
• W2165762516 cites W2035156043 @default.
• W2165762516 cites W2035282018 @default.
• W2165762516 cites W2035462700 @default.
• W2165762516 cites W2037169795 @default.
• W2165762516 cites W2040661002 @default.
• W2165762516 cites W2046664333 @default.
• W2165762516 cites W2049416977 @default.
• W2165762516 cites W2053063666 @default.
• W2165762516 cites W2062489139 @default.
• W2165762516 cites W2063512758 @default.
• W2165762516 cites W2070454528 @default.
• W2165762516 cites W2070971554 @default.
• W2165762516 cites W2071366179 @default.
• W2165762516 cites W2075791440 @default.
• W2165762516 cites W2077699648 @default.
• W2165762516 cites W2078546411 @default.
• W2165762516 cites W2078872477 @default.
• W2165762516 cites W2083451944 @default.
• W2165762516 cites W2092396732 @default.
• W2165762516 cites W2105704879 @default.
• W2165762516 cites W2110888808 @default.
• W2165762516 cites W2112047897 @default.
• W2165762516 cites W2120675188 @default.
• W2165762516 cites W2125683177 @default.
• W2165762516 cites W2128539657 @default.
• W2165762516 cites W2139553041 @default.
• W2165762516 cites W2142433545 @default.
• W2165762516 cites W2153155642 @default.
• W2165762516 cites W2159377066 @default.
• W2165762516 cites W2170218376 @default.
• W2165762516 cites W2172007938 @default.
• W2165762516 cites W4246545334 @default.
• W2165762516 cites W47608607 @default.
• W2165762516 doi "https://doi.org/10.1002/cne.10186" @default.
• W2165762516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11932941" @default.
• W2165762516 hasPublicationYear "2002" @default.
• W2165762516 type Work @default.
• W2165762516 sameAs 2165762516 @default.
• W2165762516 citedByCount "95" @default.
• W2165762516 countsByYear W21657625162012 @default.
• W2165762516 countsByYear W21657625162013 @default.
• W2165762516 countsByYear W21657625162014 @default.
• W2165762516 countsByYear W21657625162015 @default.
• W2165762516 countsByYear W21657625162016 @default.
• W2165762516 countsByYear W21657625162017 @default.
• W2165762516 countsByYear W21657625162018 @default.
• W2165762516 countsByYear W21657625162019 @default.
• W2165762516 countsByYear W21657625162021 @default.
• W2165762516 countsByYear W21657625162022 @default.
• W2165762516 crossrefType "journal-article" @default.
• W2165762516 hasAuthorship W2165762516A5003243415 @default.
• W2165762516 hasAuthorship W2165762516A5017808777 @default.
• W2165762516 hasAuthorship W2165762516A5028360919 @default.
• W2165762516 hasAuthorship W2165762516A5043062540 @default.
• W2165762516 hasAuthorship W2165762516A5043543559 @default.
• W2165762516 hasAuthorship W2165762516A5046762961 @default.
• W2165762516 hasAuthorship W2165762516A5059902188 @default.

• next