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- W2165771838 abstract "In this study we report, for the first time, the molecular analysis of HLA-DR and DQ gene frequencies in a large cohort of well-characterized type 1 (insulin-dependent) diabetes mellitus (IDDM) patients (n = 72), and ethnically matched controls (n = 59) collected in sub-Saharan Africa. High molecular mass DNA was prepared and analysed in Southern blots and by oligonucleotide typing. We have shown a strong positive association between IDDM and the Asp 57- DQB1 allele *0201 (DQw2). A rare DR4, DQw2 haplotype was also identified at high frequency in the IDDM cohort. We can now confirm that the association between Asp 57- DQB1 alleles and IDDM, previously reported in ethnically diverse cohorts collected in Western Europe, North America, and South Asia, is also present in an IDDM cohort collected in Africa." @default.
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- W2165771838 date "1992-12-01" @default.
- W2165771838 modified "2023-10-07" @default.
- W2165771838 title "Identification of Genetic Susceptibility loci for Insulin-Dependent Diabetes in sudan" @default.
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- W2165771838 doi "https://doi.org/10.1111/j.1365-3083.1992.tb01649.x" @default.
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